Schaechter's Mechanisms of Microbial Disease

Contributors v
Pr eface x
Acknowledgments xii
Figur e Cr edits xiii
PART I: PRINCIPLES 1
1 Establishment of Infection 3
Barry I. Eisenstein and Moselio Schaechter
2 The Nor mal Micr obiota 11
V incent B. Y oung
3 Biology of Infectious Agents 18
Moselio Schaechter
4 Genetic Appr oaches to Studying Bacterial
Pathogenesis 38
Peggy A. Cotter and Victor J. DiRita
5 Biological Basis for Antibacterial Action 50
N. Cary Engleberg and Victor J. DiRita
6 Innate Immunity 61
Roman Dziarski
7 Adaptive Immunity 87
Marcela F. Pasetti and Jose M. Lemme-Dumit
8 The Parasite’s W ay of Life 113
V ictor J. DiRita
9 Damage by Micr obial T oxins 123
Joseph T . Barbieri
PART II: INFECTIOUS AGENTS 135
10 Intr oduction to the Pathogenic Bacteria 137
V ictor J. DiRita
11 Staphylococci: Abscesses and T oxin-Mediated
Diseases 143
Patrick M. Schlievert and Marnie L. Peterson
12 Streptococci and Enterococci: “Strep Throat” and
Beyond 154
Kevin S. McIver
13 Pneumococcus and Bacterial Pneumonia 163
Suzanne R. Dawid and Jeffrey N. Weiser
14 Neisseriae : Gonococcus and Meningococcus 172
Ann E. Jerse and Victor J. DiRita
15 Bacter oides and Abscesses 182
Juliane Bubeck W ar denbur g
16 Enteric Bacteria: Secr etory Diarr hea 188
V ictor J. DiRita
17 Invasive and Tissue-Damaging Enteric Bacterial
Pathogens: Bloody Diarrhea and Dysentery 197
Beth A. McCormick and Victor J. DiRita
18 Pseudomonas aeruginosa : A Ubiquitous
Opportunist 211
19 Bordetella and Whooping Cough 220
Victor J. DiRita and Peggy A. Cotter
20 Clostridia: Diarrheal Disease, Tissue Infection,
Botulism, and Tetanus 227
Stephen B. Melville
21 Legionella : Parasite of Amoebae and
Macr ophages 233
Michele S. Swanson
22 Helicobacter pylori : Persistent With a Potential for
Menace 240
Jennifer M. Noto and Richard M. Peek Jr.
23 Mycobacteria: T uber culosis and Lepr osy 248
Christina T. Fiske and David W. Haas
24 Syphilis: The Gr eat Imitator 259
Noah Robbins
25 Borrelia burgdorferi and L yme Disease 265
Yi-Pin Lin and Klemen Strle
26 Bartonella Infections: Catscratch Disease, Bacillary
Angiomatosis, and Other Diseases 276
T ejal N. Gandhi
27 Chlamydiae: Genital, Ocular, and Respiratory
Pathogens 281
Breanna J. Turman and Toni Darville
28 Rocky Mountain Spotted Fever and Other
Rickettsioses 289
David H. W alker
29 Mycoplasma : Curiosity and Pathogen 296
Joel B. Baseman and Ken B. Waites
30 Strategies to Combat Bacterial Infections 302
N. Cary Engleber g
31 Biology of V iruses 317
Terence S. Dermody and Jeffrey M. Bergelson
32 Viral Infections and Exanthems of Early
Childhood 333
John V . W illiams
33 In? uenza and Its V iruses 343
Raffael Nachbagauer and Peter Palese
34 Rhinoviruses, Adenoviruses, Cor onaviruses:
The Common Cold and Beyond 351
Jason B. W einber g
35 Viral Agents of the GI Tract 362
Robert L. Atmar and Mary K. Estes
36 V iral Hepatitis 371
Andr ew W . T ai
37 Rabies 382
Brett W. Petersen and Charles E. Rupprecht
38 Arthr opod-Bor ne V iruses 389
Diane E. Grif? n
39 Human Papillomaviruses and W arts 397
Elliot J. Andr ophy
Contents 40 Alphaherpesviruses: Herpes Simplex Viruses
and Varicella-Zoster Virus 405
Neal A. DeLuca and Paul R. Kinchington
41 Beta- and Gammaherpesviruses: Cytomegalovirus
and Epstein-Barr Virus 414
W illiam J. Britt
42 The Human Retroviruses: AIDS and Other Diseases 426
Mark M. Painter and Kathleen L. Collins
43 Antiviral T r eatment Strategies 439
Claudette Poole and David W. Kimberlin
44 Vaccines and Antisera for the Prevention and Treatment
of Infectious Diseases 451
Natasha B. Halasa and H. Keipp Talbot
45 Introduction to the Fungi and Mycoses 459
Car ol A. Kauf fman
46 Endemic Mycoses 463
Car ol A. Kauf fman
47 Opportunistic Fungal Infections 470
Car ol A. Kauf fman
48 Subcutaneous, Cutaneous, and Super? cial Mycoses 478
Car ol A. Kauf fman
49 Antifungal Agents 483
Car ol A. Kauf fman
50 Intr oduction to Parasitology 488
N. Cary Engleber g
51 Blood and T issue Pr otozoa 497
N. Cary Engleber g
52 Intestinal and V aginal Pr otozoa 512
N. Cary Engleber g
53 Intestinal Helminths 521
N. Cary Engleber g
54 T issue and Blood Helminths 531
N. Cary Engleber g
55 Prion Diseases 544
C. Alan Anderson and Kenneth L. Tyler
56 Surveillance for and Response to the Emergence of
Thr eatening Pathogens 551
Sandro K. Cinti and Laura Power
PART III: PATHOPHYSIOLOGY OF
INFECTIOUS DISEASES 565
57 Diagnostic Principles 567
N. Cary Engleber g
58 Principles of Epidemiology 579
Thao P. Tran and Christian B. Ramers
59 Digestive System Infections 587
F. Matthew Kuhlmann and James M. Fleckenstein
60 Infections of the Central Nervous System 603
Roberta L. DeBiasi and Kenneth L. Tyler
61 Respiratory System Infections 619
Emily A. Abdoler
62 Urinary T ract Infections 632
Lindsay A. Petty
63 Infections of the Skin and Soft Tissue 642
Dennis L. Stevens
64 Infections of the Bones, Joints, and Muscles 653
N. Cary Engleber g
65 Sepsis 662
Suzanne F . Bradley
66 Intravascular Infection 671
Emil L. Fosbøl, Adolf W. Karchmer, and Niels E. Bruun
67 Head and Neck Infections 683
Preeti N. Malani and Mark A. Zacharek
68 Sexually T ransmitted Diseases 690
Noah Robbins
69 Infections of the Immunocompr omised Patient 697
Emily A. Abdoler
70 Acquir ed Immunode? ciency Syndr ome 703
Jane A. O’Halloran and William G. Powderly
71 Congenital and Perinatal Infections 715
Roshni Mathew
72 Zoonoses 722
N. Cary Engleber g
73 Fever: A Clinical Sign of Infection 732
Suzanne F . Bradley
74 Health Car e–Associated Infections 739
Gabriela M. Andujar Vazquez, Shira Doron,
and David R. Snydman
75 Foodbor ne Diseases 746
Adam C. Bortner and Christian B. Ramers
Appendix 755
Glossary 784
Index 817