Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
Edition:
5
ISBN/ISSN:
9781496385901
Publication Date:
July 11, 2019
2019-07-11
9781496385901
Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug ...
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Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
- Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
- An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
- Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
- More than 200 carefully written study questions , with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
- New and updated examples connect chapter content to real-world settings.
- Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities!- Read directly on your preferred device(s), such as computer, tablet, or smartphone
- Easily convert to audiobook, powering your content with natural language text-to-speech
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Edition5ISBN/ISSN9781496385901Product FormatVitalsource Interactive eBookEdition5Publication DateJuly 11, 2019
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- Hartmut Derendorf Ph.D.
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xi
About the Authors v
Preface vii
Nonproprietary and Brand Names of Drugs in Text and Illustrations xiii
Definition of Symbols xix
SECTION 1 BASIC CONSIDERATIONS 1
CHAPTER 1 Therapeutic Relevance 3
CHAPTER 2 Fundamental Concepts and T erminology 19
SECTION 2 EXPOSURE AND RESPONSE AFTER
A SINGLE DOSE 51
CHAPTER 3 Kinetics Following an Intravenous Bolus Dose 53
CHAPTER 4 Membranes and Distribution 77
CHAPTER 5 Elimination 119
CHAPTER 6 Kinetics Following an Extravascular Dose 169
CHAPTER 7 Absorption 197
CHAPTER 8 Response 233
SECTION 3 THERAPEUTIC REGIMENS 265
CHAPTER 9 Therapeutic W indow 267
CHAPTER 10 Constant-Rate Input 283
CHAPTER 11 Multiple-Dose Regimens 319
SECTION 4 INDIVIDUALIZATION 359
CHAPTER 12 V ariability 361
CHAPTER 13 Genetics 393
CHAPTER 14 Age, W eight, and Gender 411
CHAPTER 15 Disease 443
CHAPTER 16 Nonlinearities 491
CHAPTER 17 Drug Interactions 531
CHAPTER 18 Initiating and Managing Therapy 577
SECTION 5 SUPPLEMENTAL TOPICS 611
CHAPTER 19 Distribution Kinetics 613
CHAPTER 20 Metabolites and Drug Response 657
CONTENTS xii Contents
CHAPTER 21 Protein Drugs 687
CHAPTER 22 Prediction and Refinement of Human Kinetics from
In Vitro, Preclinical, and Early Clinical Data 731
APPENDICES 759
APPENDIX A Assessment of AUC 759
APPENDIX B Ionization and the pH Partition Hypothesis 763
APPENDIX C Distribution of Drugs Extensively Bound to
Plasma Proteins 767
APPENDIX D Plasma-to-Blood Concentration Ratio 775
APPENDIX E W ell-Stirred Model of Hepatic Clearance 777
APPENDIX F Absorption Kinetics 781
APPENDIX G W agner -Nelson Method 785
APPENDIX H Mean Residence T ime 789
APPENDIX I Amount of Drug in Body on Accumulation
to Plateau 795
APPENDIX J Introduction to MS Excel Simulations 799
APPENDIX K Answers to Study Problems 805
Index 903 -
- Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
- An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
- Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
- More than 200 carefully written study questions , with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
- New and updated examples connect chapter content to real-world settings.
- Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities!- Read directly on your preferred device(s), such as computer, tablet, or smartphone
- Easily convert to audiobook, powering your content with natural language text-to-speech
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Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
ISBN/ISSN: 9781496385901
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