Schaechter's Mechanisms of Microbial Disease

Preface iii
Acknowledgments iv
Contributors v
Figure Credits xi
PART I: PRINCIPLES 1
1 Establishment of Infectious Diseases 3
Barry I. Eisenstein and Moselio Schaechter
2 The Normal Microbiota 11
Barry I. Eisenstein, Moselio Schaechter, and
Vincent Young
3 Biology of Infectious Agents 18
Moselio Schaechter
4 Genetic Approaches to Studying Bacterial
Pathogenesis 38
Peggy A. Cotter
5 Biological Basis for Antibacterial Action 55
Cary Engleberg and Victor DiRita
6 Innate Immunity 66
Roman Dziarski
7 Adaptive Immunity 91
Carl Waltenbaugh and Roger Melvold
8 The Parasite’s Way of Life 117
Victor J. DiRita
9 Damage by Microbial Toxins 127
Joseph T. Barbieri
PART II: INFECTIOUS AGENTS 141
SECTION 1 • BACTERIA
10 Introduction to the Pathogenic Bacteria 143
Victor J. DiRita
11 Staphylococci: Abscesses and Toxin-
Mediated Diseases 149
Patrick M. Schlievert and Marnie L. Peterson
12 Streptococci and Enterococci: “Strep Throat”
and Beyond 160
Kevin S. McIver
13 Pneumococcus and Bacterial
Pneumonia 169
Jeffrey N. Weiser
14 Neisseriae: Gonococcus and
Meningococcus 178
Ann E. Jerse and Victor DiRita
15 Bacteroides, Intra-Abdominal Infection,
and Abscesses 188
Laurie E. Comstock
16 Enteric Bacteria: Secretory Diarrhea 195
Victor J. DiRita
17 Invasive and Tissue-Damaging Enteric
Bacterial Pathogens: Bloody Diarrhea and
Dysentery 205
Beth A. McCormick and Victor J. DiRita
18 Pseudomonas aeruginosa: A Ubiquitous
Opportunist 220
Joanna B. Goldberg
19 Bordetella and Whooping Cough 228
Victor J. DiRita and Peggy A. Cotter
20 Clostridia: Diarrheal Disease, Tissue
Infection, Botulism, and Tetanus 235
Stephen Melville
21 Legionella: Parasite of Amoebae and
Macrophages 242
Michele Swanson and Cary Engleberg
22 Helicobacter pylori: Pathogenesis of a
Persistent Bacterial Infection 249
Jennifer M. Noto and Richard M. Peek Jr
23 Mycobacteria: Tuberculosis and
Leprosy 257
Christina Fiske and David Haas
24 Syphilis: A Disease with a History 269
John R. Ebright and Jack D. Sobel
25 Borrelia burgdorferi and Lyme Disease 277
Mollie W. Jewett, Jenifer Coburn, and John
Leong
26 Cat Scratch Disease, Bacillary Angiomatosis,
and Other Bartonelloses 287
Christoph Dehio
27 Chlamydiae: Genital, Ocular, and Respiratory
Pathogens 292
Toni Darville
28 Rocky Mountain Spotted Fever and Other
Rickettsioses 301
David H. Walker
29 Mycoplasma: Curiosity and Pathogen 308
Joel B. Baseman and Ken B. Waites
30 Strategies to Combat Bacterial
Infections 314
Cary Engleberg
SECTION 2 • VIRUSES
31 Biology of Viruses 321
Terence S. Dermody and Jeffrey M. Bergelson
32 Picornaviruses and Coronaviruses 337
Vincent R. Racaniello and Mark R. Denison
33 Arthropodborne Viruses 348
Diane E. Griffi n
34 Paramyxoviruses: Measles Virus and
Respiratory Syncytial Virus 356
John V. Williams and James E. Crowe Jr
35 Rabies 367
Charles E. Rupprecht and Brett W. Petersen
36 Infl uenza and Its Viruses 374
Peter Palese
37 Rotaviruses, Noroviruses, and Other Viral
Agents of Gastroenteritis 382
Robert L. Atmar and Mary K. Estes
38 The Human Retroviruses: AIDS and Other
Diseases 388
Robert T. Schooley
39 Adenoviruses 401
Gary Ketner
40 Human Papillomaviruses and Warts 411
Elliot J. Androphy
41 Alphaherpesviruses: Herpes Simplex Viruses
and Varicella-Zoster Virus 419
Patricia G. Spear
42 Beta- and Gammaherpesviruses:
Cytomegalovirus and Epstein-Barr
Virus 428
William J. Britt
43 Viral Hepatitis 438
Donald E. Ganem
44 Antiviral Treatment Strategies 449
Karen C. Bloch and Julie E. Reznicek
45 Vaccines and Antisera for the Prevention and
Treatment of Infectious Diseases 461
Natasha B. Halasa and H. Keipp Talbot
SECTION 3 • FUNGI
46 Introduction to the Fungi and Mycoses 468
Carol A. Kauffman
47 Endemic Mycoses 472
Carol A. Kauffman
48 Opportunistic Fungal Infections 479
Carol A. Kauffman
49 Subcutaneous, Cutaneous, and Superficial
Mycoses 487
Carol A. Kauffman
50 Antifungal Agents 492
Carol A. Kauffman
SECTION 4 • PARASITES
51 Introduction to Parasitology 496
Cary Engleberg
52 Blood and Tissue Protozoa 506
Cary Engleberg
53 Intestinal and Vaginal Protozoa 521
Cary Engleberg
54 Intestinal Helminths 530
Cary Engleberg
55 Tissue and Blood Helminths 540
Cary Engleberg
SECTION 5 • MISCELLANEOUS
PATHOGENS
56 Prion Diseases 552
C. Alan Anderson and Kenneth L. Tyler
57 Biological Agents of Warfare and
Terrorism 560
Sandro K. Cinti and Philip C. Hanna
PART III: PATHOPHYSIOLOGY
OF INFECTIOUS
DISEASES 573
58 Diagnostic Principles 575
Cary Engleberg
59 Principles of Epidemiology 586
Christian B. Ramers
60 Digestive System Infections 594
David Acheson and James M. Fleckenstein
61 Infections of the Central Nervous
System 612
Roberta L. DeBiasi and Kenneth L. Tyler
62 Respiratory System Infections 628
Melissa A. Miller and Kevin R. Flaherty
63 Urinary Tract Infections 641
Lindsay E. Nicolle
64 Infections of the Skin and Soft Tissue 651
Dennis L. Stevens
65 Infections of the Bones, Joints, and
Muscles 662
Joseph J. Nania
66 Sepsis 671
Suzanne F. Bradley
67 Intravascular Infection 679
Rasmus V. Rasmussen, Adolf W. Karchmer,
Niels E. Bruun, and Vance G. Fowler
68 Head and Neck Infections 689
Preeti N. Malani and Mark A. Zacharek
69 Sexually Transmitted Diseases 697
Jack Sobel and Jack Ebright
70 Infections of the Immunocompromised
Patient 704
Michael A. Lane and Edgar Turner Overton
71 Acquired Immunodefi ciency Syndrome 710
William G. Powderly
72 Congenital and Perinatal Infections 722
Roshni Mathew and Charles G. Prober
73 Zoonoses 729
Daniel S. Shapiro
74 Fever: A Clinical Sign of Infection 740
Suzanne F. Bradley
75 Health Care–Associated Infections 747
David R. Snydman and Shira Doron
76 Foodborne Diseases 753
Christian B. Ramers
Appendix A 761
Appendix B 799
Index 811