PART I: EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF HEART FAILURE
1 Epidemiology of Heart Failure
Mikhail Kosiborod and Harlan M. Krumholz
2 Cellular and Molecular Abnormalities in Failing Cardiac Myocytes
Rachel Wilson, Xiongwen Chen, and Steven R. Houser
3 Determinants of Cardiac Remodeling and Progression to Heart Failure
Jean-Jacques Mercadier
4 Cytoskeletal Abnormalities in Cardiocytes During Heart Failure
George Cooper, IV
5 Abnormalities in Calcium Cycling in Heart Failure
Judith Karen Gwathmey, Federica del Monte, and Roger Joseph Hajjar
6 Abnormalities in Cardiac Contraction: Systolic Dysfunction
Blase A. Carabello
7 Heart Failure with Normal Ejection Fraction
Carolyn S. P. Lam and Margaret Redfield
8 Cellular, Molecular, and Structural Changes During Cardiac Remodeling
Richard D. Patten
9 Remodeling of the Cardiac Interstitium in Heart Failure
Karl T. Weber, Yao Sun, Syamal K. Bhattacharya, Robert A. Ahokas, and Ivan C. Gerling
10 The Renin-Angiotensin System
Barry H. Greenberg
11 Sympathetic Nervous System in Heart Failure
G. Michael Felker, Wilson S. Colucci, and Howard A. Rockman
12 Other Neurohormonal Systems
Steven Goldsmith and Bradley A. Bart
13 Cytokines as Mediators of Disease Progression in the Failing Heart
Douglas L. Mann
14 The Peripheral Circulation in Heart Failure
Anju Nohria and Mark A. Creager
15 The Kidney in Heart Failure
JoAnn Lindenfeld and Robert W. Schrier
PART II: DIFFERENTIAL DIAGNOSIS OF CONGESTIVE HEART FAILURE
16 Risk Factors for Heart Failure
Javed Butler
17 Heart Failure Secondary to Coronary Artery
Disease
Roger M. Mills, Jr. and Mouaz Al-Mallah
18 The Cardiomyopathic and Inflammatory Diseases
Jeffrey David Hosenpud and Bart L. Cox
19 Congestive Heart Failure as a Consequence of Valvular Heart Disease
William J. McKenna, Denis Pellerin, Niall G. Mahon, and Barry H. Greenberg
20 Congestive Heart Failure Secondary to Congenital Heart Disease
Yuk M. Law and David J. Sahn
21 Right Heart Failure
Marvin A. Konstam, Sunny Srivastava, and James E. Udelson
22 Heart Failure in Cardiac Tamponade, Constrictive Pericarditis, and Restrictive Cardiomyopathy
Ralph Shabetai
PART III: PHARMACOLOGIC THERAPY OF HEART FAILURE
23 Clinical Pharmacokinetics in Congestive Heart Failure
Paul Nolan, Alan S. Nies, and Paul E. Fenster
24 Traditional Diuretics and Other Diuresing Agents
Stephen S. Gottlieb
25 Digitalis Glycosides
Paul J. Hauptman and Ralph A. Kelly
26 Inhibition of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure: Rationale, Results, and Current Recommendations
John R. Teerlink, Kiran K. Khush, and Barry M. Massie
27 Vasodilators
Uri Elkayam, Fahed Bitar, Sarkis Kiramijyian, Parta Hatamizadeh, Philip F. Binkley, and Carl V. Leier
28 Beta-Blocker Therapy for Heart Failure
Henry Krum
29 Inotropic Agents
Ozlem Soran and Arthur M. Feldman
PART IV: CLINICAL APPROACH TO ACUTE AND CHRONIC HEART FAILURE
30 Primary Prevention of Heart Failure
David W. Baker and Stephen D. Persell
31 Physical Examination in Heart Failure
Kanu Chatterjee
32 Natriuretic Peptides as Biomarkers to Detect, Risk-Stratify, and Manage Patients with Heart Failure
Susan Isakson and Alan Maisel
33 Noninvasive Imaging Techniques for the Assessment of the Patient with Heart Failure
Swaminatha V. Gurudevan, Peng Li, Mani A. Vannan, and Jagat Narula
34 Management of Acute and Decompensated Heart Failure
Gary S. Francis and W. H. Wilson Tang
35 The Medical Management of Chronic Heart Failure in Patients with Systolic Dysfunction
Barry H. Greenberg
36 Biventricular Pacing in Congestive Heart Failure
William T. Abraham
37 The Heart Failure Clinic
Marc A. Silver
38 Exercise and Rehabilitation in Congestive Heart Failure
Donna M. Mancini and Rebecca P. Streeter
39 Impact and Treatment of Comorbidities in Heart Failure
Tamara B. Horwich and Gregg C. Fonarow
40 Management of Supraventricular Arrhythmias in Patients with Heart Failure
Gregory K. Feld, Doug Gibson, and David Krummen
41 Prevention of Sudden Death in Heart Failure
Phillip B. Adamson and Emilio Vanoli
42 Pathogenesis and Therapy of Thrombosis in Patients with Congestive Heart Failure
Jody L. Kujovich, Scott H. Goodnight, and Barry Massie
43 Ultrafiltration Therapies for Congestive Heart Failure
Maria Rosa Costanzo
44 Surgical Approaches to Patients with Chronic Congestive Heart Failure
Edwin C. McGee, Jr., Kathleen L. Grady, and Patrick M. McCarthy
45 Use of Mechanical Devices in Treating Heart Failure
Timothy J. Myers, Reynolds M. Delgado, III, and O. H. Frazier
46 Cardiac Transplantation
Anantharam V. Kalya and Jeffrey David Hosenpud
47 Strategies for Gene and Cell Therapy in Heart Failure
Shi Yin Foo and Anthony Rosenzweig
48 End-of-Life Considerations
Marc A. Silver
49 Future Directions
Jeffrey David Hosenpud and Barry H. Greenberg