Selected as a Doody's Core Title for 2022 and 2023!
Known for generations as the most comprehensive foundational text on medical microbiology, Schaechter's Mechanisms of Microbial Disease delivers a thorough understanding of microbial agents and the pathophysiology of microbial diseases. This trusted text is universally praised for "telling the story of a pathogen" in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms. Content is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula.
This updated 6th Edition reflects the latest advances in the field, including significant enhancements to the coverage of serious threats to global health such as COVID-19, respiratory and childhood viruses, and sexually transmitted diseases. New illustrations and additional learning features further clarify concepts, reinforce understanding, and help users confidently prepare for board exams and beyond.
Abundant full-color images clarify microbial concepts, structures, and processes in vivid detail.
New Subject Review Tables broaden students’ understanding of chapter content with additional context and detail.
Paradigm boxes reinforce general principles through key examples.
Case Studies with problem-solving questions, questions provide insight into clinical applications of microbiology, challenge students to apply what they’ve learned to common clinical scenarios.
Key Concepts keep students focused on essential information.
Suggested Readings guide students to relevant field research.
Bolded Terms familiarize students with new or challenging terms.
New content related to the COVID-19 pandemic concerning the virology, clinical features, treatment, and prevention of coronaviruses added to several relevant chapters prepares students for the clinical challenges ahead.
Edition
6
ISBN/ISSN
9781975151485
Product Format
Paperback Book
Pages
880
Edition
6
Publication Date
December 10, 2021
N. Cary Engleberg MD
Victor DiRita PhD
University of Michigan School of Medicine, Ann Arbor, MI
Michael Imperiale Ph.D
Contributors v Pr eface x Acknowledgments xii Figur e Cr edits xiii PART I: PRINCIPLES 1 1 Establishment of Infection 3 Barry I. Eisenstein and Moselio Schaechter 2 The Nor mal Micr obiota 11 V incent B. Y oung 3 Biology of Infectious Agents 18 Moselio Schaechter 4 Genetic Appr oaches to Studying Bacterial Pathogenesis 38 Peggy A. Cotter and Victor J. DiRita 5 Biological Basis for Antibacterial Action 50 N. Cary Engleberg and Victor J. DiRita 6 Innate Immunity 61 Roman Dziarski 7 Adaptive Immunity 87 Marcela F. Pasetti and Jose M. Lemme-Dumit 8 The Parasite’s W ay of Life 113 V ictor J. DiRita 9 Damage by Micr obial T oxins 123 Joseph T . Barbieri PART II: INFECTIOUS AGENTS 135 10 Intr oduction to the Pathogenic Bacteria 137 V ictor J. DiRita 11 Staphylococci: Abscesses and T oxin-Mediated Diseases 143 Patrick M. Schlievert and Marnie L. Peterson 12 Streptococci and Enterococci: “Strep Throat” and Beyond 154 Kevin S. McIver 13 Pneumococcus and Bacterial Pneumonia 163 Suzanne R. Dawid and Jeffrey N. Weiser 14 Neisseriae : Gonococcus and Meningococcus 172 Ann E. Jerse and Victor J. DiRita 15 Bacter oides and Abscesses 182 Juliane Bubeck W ar denbur g 16 Enteric Bacteria: Secr etory Diarr hea 188 V ictor J. DiRita 17 Invasive and Tissue-Damaging Enteric Bacterial Pathogens: Bloody Diarrhea and Dysentery 197 Beth A. McCormick and Victor J. DiRita 18 Pseudomonas aeruginosa : A Ubiquitous Opportunist 211 19 Bordetella and Whooping Cough 220 Victor J. DiRita and Peggy A. Cotter 20 Clostridia: Diarrheal Disease, Tissue Infection, Botulism, and Tetanus 227 Stephen B. Melville 21 Legionella : Parasite of Amoebae and Macr ophages 233 Michele S. Swanson 22 Helicobacter pylori : Persistent With a Potential for Menace 240 Jennifer M. Noto and Richard M. Peek Jr. 23 Mycobacteria: T uber culosis and Lepr osy 248 Christina T. Fiske and David W. Haas 24 Syphilis: The Gr eat Imitator 259 Noah Robbins 25 Borrelia burgdorferi and L yme Disease 265 Yi-Pin Lin and Klemen Strle 26 Bartonella Infections: Catscratch Disease, Bacillary Angiomatosis, and Other Diseases 276 T ejal N. Gandhi 27 Chlamydiae: Genital, Ocular, and Respiratory Pathogens 281 Breanna J. Turman and Toni Darville 28 Rocky Mountain Spotted Fever and Other Rickettsioses 289 David H. W alker 29 Mycoplasma : Curiosity and Pathogen 296 Joel B. Baseman and Ken B. Waites 30 Strategies to Combat Bacterial Infections 302 N. Cary Engleber g 31 Biology of V iruses 317 Terence S. Dermody and Jeffrey M. Bergelson 32 Viral Infections and Exanthems of Early Childhood 333 John V . W illiams 33 In? uenza and Its V iruses 343 Raffael Nachbagauer and Peter Palese 34 Rhinoviruses, Adenoviruses, Cor onaviruses: The Common Cold and Beyond 351 Jason B. W einber g 35 Viral Agents of the GI Tract 362 Robert L. Atmar and Mary K. Estes 36 V iral Hepatitis 371 Andr ew W . T ai 37 Rabies 382 Brett W. Petersen and Charles E. Rupprecht 38 Arthr opod-Bor ne V iruses 389 Diane E. Grif? n 39 Human Papillomaviruses and W arts 397 Elliot J. Andr ophy Contents 40 Alphaherpesviruses: Herpes Simplex Viruses and Varicella-Zoster Virus 405 Neal A. DeLuca and Paul R. Kinchington 41 Beta- and Gammaherpesviruses: Cytomegalovirus and Epstein-Barr Virus 414 W illiam J. Britt 42 The Human Retroviruses: AIDS and Other Diseases 426 Mark M. Painter and Kathleen L. Collins 43 Antiviral T r eatment Strategies 439 Claudette Poole and David W. Kimberlin 44 Vaccines and Antisera for the Prevention and Treatment of Infectious Diseases 451 Natasha B. Halasa and H. Keipp Talbot 45 Introduction to the Fungi and Mycoses 459 Car ol A. Kauf fman 46 Endemic Mycoses 463 Car ol A. Kauf fman 47 Opportunistic Fungal Infections 470 Car ol A. Kauf fman 48 Subcutaneous, Cutaneous, and Super? cial Mycoses 478 Car ol A. Kauf fman 49 Antifungal Agents 483 Car ol A. Kauf fman 50 Intr oduction to Parasitology 488 N. Cary Engleber g 51 Blood and T issue Pr otozoa 497 N. Cary Engleber g 52 Intestinal and V aginal Pr otozoa 512 N. Cary Engleber g 53 Intestinal Helminths 521 N. Cary Engleber g 54 T issue and Blood Helminths 531 N. Cary Engleber g 55 Prion Diseases 544 C. Alan Anderson and Kenneth L. Tyler 56 Surveillance for and Response to the Emergence of Thr eatening Pathogens 551 Sandro K. Cinti and Laura Power PART III: PATHOPHYSIOLOGY OF INFECTIOUS DISEASES 565 57 Diagnostic Principles 567 N. Cary Engleber g 58 Principles of Epidemiology 579 Thao P. Tran and Christian B. Ramers 59 Digestive System Infections 587 F. Matthew Kuhlmann and James M. Fleckenstein 60 Infections of the Central Nervous System 603 Roberta L. DeBiasi and Kenneth L. Tyler 61 Respiratory System Infections 619 Emily A. Abdoler 62 Urinary T ract Infections 632 Lindsay A. Petty 63 Infections of the Skin and Soft Tissue 642 Dennis L. Stevens 64 Infections of the Bones, Joints, and Muscles 653 N. Cary Engleber g 65 Sepsis 662 Suzanne F . Bradley 66 Intravascular Infection 671 Emil L. Fosbøl, Adolf W. Karchmer, and Niels E. Bruun 67 Head and Neck Infections 683 Preeti N. Malani and Mark A. Zacharek 68 Sexually T ransmitted Diseases 690 Noah Robbins 69 Infections of the Immunocompr omised Patient 697 Emily A. Abdoler 70 Acquir ed Immunode? ciency Syndr ome 703 Jane A. O’Halloran and William G. Powderly 71 Congenital and Perinatal Infections 715 Roshni Mathew 72 Zoonoses 722 N. Cary Engleber g 73 Fever: A Clinical Sign of Infection 732 Suzanne F . Bradley 74 Health Car e–Associated Infections 739 Gabriela M. Andujar Vazquez, Shira Doron, and David R. Snydman 75 Foodbor ne Diseases 746 Adam C. Bortner and Christian B. Ramers Appendix 755 Glossary 784 Index 817
Abundant full-color images clarify microbial concepts, structures, and processes in vivid detail.
New Subject Review Tables broaden students’ understanding of chapter content with additional context and detail.
Paradigm boxes reinforce general principles through key examples.
Case Studies with problem-solving questions, questions provide insight into clinical applications of microbiology, challenge students to apply what they’ve learned to common clinical scenarios.
Key Concepts keep students focused on essential information.
Suggested Readings guide students to relevant field research.
Bolded Terms familiarize students with new or challenging terms.
New content related to the COVID-19 pandemic concerning the virology, clinical features, treatment, and prevention of coronaviruses added to several relevant chapters prepares students for the clinical challenges ahead.
Digital features:
NEW! Board-style mini exams strengthen students’ preparation for board exams with 20-25 questions aligned to each major subsection in the text.
NEW! Topic links emphasize unifying principles and paradigms and allow students to easily navigate between microbial agents, diseases, and effects of diseases on different body systems for the most efficient study.
End-of-chapter review questions help students fully process important concepts.
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