Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug ...
Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Key updates reflect advances in PK/PD as related to clinical decision-making and drug research and development.
An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
New and updated examples connect chapter content to real-world settings.
Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more
Edition
5
ISBN/ISSN
9781496385048
Product Format
Paperback Book
Trim Size
7 x 10
Pages
864
Edition
5
Publication Date
August 8, 2019
Weight
3.65
Hartmut Derendorf Ph.D.
Stephan Schmidt Ph.D
xi About the Authors v Preface vii Nonproprietary and Brand Names of Drugs in Text and Illustrations xiii Definition of Symbols xix SECTION 1 BASIC CONSIDERATIONS 1 CHAPTER 1 Therapeutic Relevance 3 CHAPTER 2 Fundamental Concepts and T erminology 19 SECTION 2 EXPOSURE AND RESPONSE AFTER A SINGLE DOSE 51 CHAPTER 3 Kinetics Following an Intravenous Bolus Dose 53 CHAPTER 4 Membranes and Distribution 77 CHAPTER 5 Elimination 119 CHAPTER 6 Kinetics Following an Extravascular Dose 169 CHAPTER 7 Absorption 197 CHAPTER 8 Response 233 SECTION 3 THERAPEUTIC REGIMENS 265 CHAPTER 9 Therapeutic W indow 267 CHAPTER 10 Constant-Rate Input 283 CHAPTER 11 Multiple-Dose Regimens 319 SECTION 4 INDIVIDUALIZATION 359 CHAPTER 12 V ariability 361 CHAPTER 13 Genetics 393 CHAPTER 14 Age, W eight, and Gender 411 CHAPTER 15 Disease 443 CHAPTER 16 Nonlinearities 491 CHAPTER 17 Drug Interactions 531 CHAPTER 18 Initiating and Managing Therapy 577 SECTION 5 SUPPLEMENTAL TOPICS 611 CHAPTER 19 Distribution Kinetics 613 CHAPTER 20 Metabolites and Drug Response 657 CONTENTS xii Contents CHAPTER 21 Protein Drugs 687 CHAPTER 22 Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data 731 APPENDICES 759 APPENDIX A Assessment of AUC 759 APPENDIX B Ionization and the pH Partition Hypothesis 763 APPENDIX C Distribution of Drugs Extensively Bound to Plasma Proteins 767 APPENDIX D Plasma-to-Blood Concentration Ratio 775 APPENDIX E W ell-Stirred Model of Hepatic Clearance 777 APPENDIX F Absorption Kinetics 781 APPENDIX G W agner -Nelson Method 785 APPENDIX H Mean Residence T ime 789 APPENDIX I Amount of Drug in Body on Accumulation to Plateau 795 APPENDIX J Introduction to MS Excel Simulations 799 APPENDIX K Answers to Study Problems 805 Index 903
Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
More than 200 carefully written study questions , with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
New and updated examples connect chapter content to real-world settings.
Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more
Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
ISBN/ISSN: 9781496385048
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