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Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications

9781496385048
ISBN/ISSN
9781496385048
Publication Date
August 8, 2019
2019-08-8
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9781496385048
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  • Description
    Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
    • Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
    • An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
    • Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
    • More than 200 carefully written study questions , with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
    • New and updated examples connect chapter content to real-world settings.
    • Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
    • eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more
  • Specs
    Edition
    5
    ISBN/ISSN
    9781496385048
    Product Format
    PB-Paperback
    Trim Size
    7 x 10
    Pages
    864
    Edition
    5
    Publication Date
    August 8, 2019
    Weight
    4.3
  • Hartmut Derendorf Ph.D.
    Stephan Schmidt Ph.D
  • Table of contents
    xi
    About the Authors v
    Preface vii
    Nonproprietary and Brand Names of Drugs in Text and Illustrations xiii
    Definition of Symbols xix
    SECTION 1 BASIC CONSIDERATIONS 1
    CHAPTER 1 Therapeutic Relevance 3
    CHAPTER 2 Fundamental Concepts and T erminology 19
    SECTION 2 EXPOSURE AND RESPONSE AFTER
    A SINGLE DOSE 51
    CHAPTER 3 Kinetics Following an Intravenous Bolus Dose 53
    CHAPTER 4 Membranes and Distribution 77
    CHAPTER 5 Elimination 119
    CHAPTER 6 Kinetics Following an Extravascular Dose 169
    CHAPTER 7 Absorption 197
    CHAPTER 8 Response 233
    SECTION 3 THERAPEUTIC REGIMENS 265
    CHAPTER 9 Therapeutic W indow 267
    CHAPTER 10 Constant-Rate Input 283
    CHAPTER 11 Multiple-Dose Regimens 319
    SECTION 4 INDIVIDUALIZATION 359
    CHAPTER 12 V ariability 361
    CHAPTER 13 Genetics 393
    CHAPTER 14 Age, W eight, and Gender 411
    CHAPTER 15 Disease 443
    CHAPTER 16 Nonlinearities 491
    CHAPTER 17 Drug Interactions 531
    CHAPTER 18 Initiating and Managing Therapy 577
    SECTION 5 SUPPLEMENTAL TOPICS 611
    CHAPTER 19 Distribution Kinetics 613
    CHAPTER 20 Metabolites and Drug Response 657
    CONTENTS xii Contents
    CHAPTER 21 Protein Drugs 687
    CHAPTER 22 Prediction and Refinement of Human Kinetics from
    In Vitro, Preclinical, and Early Clinical Data 731
    APPENDICES 759
    APPENDIX A Assessment of AUC 759
    APPENDIX B Ionization and the pH Partition Hypothesis 763
    APPENDIX C Distribution of Drugs Extensively Bound to
    Plasma Proteins 767
    APPENDIX D Plasma-to-Blood Concentration Ratio 775
    APPENDIX E W ell-Stirred Model of Hepatic Clearance 777
    APPENDIX F Absorption Kinetics 781
    APPENDIX G W agner -Nelson Method 785
    APPENDIX H Mean Residence T ime 789
    APPENDIX I Amount of Drug in Body on Accumulation
    to Plateau 795
    APPENDIX J Introduction to MS Excel Simulations 799
    APPENDIX K Answers to Study Problems 805
    Index 903
  • Features
    • Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
    • An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
    • Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
    • More than 200 carefully written study questions , with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
    • New and updated examples connect chapter content to real-world settings.
    • Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
    • eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more
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