Principles and Practice of Palliative Care and Support Oncology

CONTENTS
Contributing Authors v
Preface xiii
Acknowledgments xv
SECTION 1
Symptoms and Syndromes 1
Part A: Pain
1. Neuropathic, Bone, and Visceral Pain
Syndromes 2
Terry L. Barrett and Emily J. Martin
2. Opioid Pharmacotherapy 22
Alexandra L. McPherson, Mary Lynn
McPherson, and Judith A. Paice
3. Nonpharmacologic Management of Pain 44
Ryan Tourtellot and Angela K. M. Lipshutz
4. Interventional Approach to Pain 58
Philip S. Kim, Andrew Mannes, and Russell
R. Lonser
5. Treatment Planning in Palliative
Radiotherapy 70
Christen R. Elledge and Sara R. Alcorn
6. Pathophysiology of Chemotherapy-Induced
Peripheral Neuropathy 88
Xiao-Min Wang, Jane M. Fall-Dickson,
Zhang-Jin Zhang, and Tanya J. Lehky
Part B: Constitutional Symptoms
7. Cancer-Related Fatigue 100
Xin Shelley Wang
8. Fever and Sweats 114
Christopher Ahern and Elizabeth Prsic
9. Hot Flashes 127
Cindy S. Tofthagen and Charles L. Loprinzi
Part C: Gastrointestinal Symptoms and Syndromes
10. Anorexia/Weight Loss 141
Egidio Del Fabbro and Eduardo Bruera
11. Swallowing and Speech Considerations in
Palliative Care 164
Beth I. Solomon and Monique C. King
12. Chemotherapy-Related Nausea and Vomiting
and Treatment-Related Nausea
and Vomiting 180
Han Le
13. Assessment and Management of Chronic
Nausea and Vomiting 194
Lakshmi Vaidyanathan
14. Diarrhea, Malabsorption, and
Constipation 207
Erica Schockett and Pallavi Doddakashi
15. Bowel Obstruction 226
Maria Pia Morelli
16. Diagnosis and Management of
Effusions 245
Gary T. Buckholz and Charles F. von
Gunten
17. Hiccups and Other Gastrointestinal
Symptoms 258
Nabeel Sarhill, Fade Mahmoud, and Donato
G. Dumlao
18. Oral Manifestations and Complications of
Cancer Therapy 273
Jane M. Fall-Dickson, Madeline R. Kozak,
and Ann M. Berger
Part D: Skin
19. Pruritus 295
Ivy Akid and Ambereen K. Mehta
20. Management of Tumor-Related Skin
Disorders 307
Shali Zhang
21. Dermatologic Adverse Events during
Treatment 322
Brianna Olamiju, Sara Yumeen, Y evgeniy
Balagula, Alyx Rosen Aigen, and Jonathan
Scott Leventhal
22. Management of Pressure Injury,
Fungating Malignant Wounds, Fistulas,
and Stomas 337
Sonika Pandey and Linda J. Stricker
23. Lymphedema 352
Vaughan L. Keeley
Part E: Cardiopulmonary and Vascular
Syndromes
24. Dyspnea in the Cancer Patient 366
Ann M. Berger
25. Hemoptysis, Airway Obstruction,
Bronchospasm, Cough, and Pulmonary
Complications/Symptoms of Cancer and Its
Treatment 380
Sebastian Cousins, Hunter Groninger, and
Jaya Vijayan 26. Prevention, Assessment, and Management
of Treatment-Induced Cardiac Disease in
Cancer Patients 396
Krishna Upadhyaya, Sarah C. Hull, Ben A.
Lin, Elizabeth Prsic, Mariana Henry, and
Lauren A. Baldassarre
27. Noninvasive Respiratory Support and
Palliative Care 410
John R. Bach and Liping Wang
Part F: Genitourinary Symptoms and Syndromes
28. Urologic Issues in Palliative Care 421
Hiren V . Patel, Brian Shinder, Adam R.
Metwalli, Peter A. Pinto, and Eric A. Singer
29. Impact of Hepatic and Renal Dysfunction on
Pharmacology of Palliative Care Drugs 443
Katelyn Stepanyan and Thomas Strouse
Part G: Metabolic Disorders
30. Metabolic Disorders in the Cancer
Patient 451
Victoria Anderson and Jaydira Del Rivero
31. Infectious Complications/Management 465
Juan C. Gea-Banacloche and Jennifer M.
Cuellar-Rodríguez
Part H: Selected Neurologic Symptoms and
Syndromes
32. Management of Intracranial
Metastases 482
Karine A. Al Feghali and Caroline Chung
33. Management of Spinal Cord and Cauda
Equina Compression 494
Sharon M. Weinstein and Jason G. Ramirez
Part I: Selected Psychiatric Symptoms and
Syndromes
34. Recognizing and Managing
Delirium 512
Elizabeth L. Cobbs and Jacob W . Phillips
35. Depression and Anxiety in Palliative
Care 526
Paul Noufi, Haniya Raza, and
Maryland Pao
36. Cognitive Decline Following Cancer
Treatment 554
Elizabeth Ryan, Alexandra M. Gaynor,
Katrazyna McNeal, Tim A. Ahles, and James
C. Root
37. Substance Use Disorders and Palliative
Care 570
Karen Blackstone
SECTION II
Issues in Palliative Care 584
Part A: Definitions and Models
38. Hospice 585
Martha L. Twaddle and Laura Patel
Part B: Assessment Issues
39. Cultural Issues in Palliatives and Supportive
Oncology 595
Joseph F. O’Neill, Margaret M. Mahon, and
Gregory Pappas
40. Communication During Transitions of
Care 600
Anne M. Kelemen, Clara Van Gerven, and
Terry Altilio
41. The Family Meeting 614
Sumi K. Misra and Mohana B. Karlekar
Part C: Other Issues in Palliative Care
42. Psychosocial Consequences of Advanced
Cancer 626
James R. Zabora and Matthew J. Loscalzo
43. Disorders of Sexuality and Reproduction 645
Mary K. Hughes
44. Caregiving in the Home 656
Betty Ferrell and Pierce DiMauro
45. Management of Symptoms in the Actively
Dying Patient 670
Teresa Khoo and Christopher J. Pietras
46. Spirituality 683
Christina M. Puchalski
47. Grief and Bereavement 703
Carol Kummet and Susan E. Merel
48. Staff Stress and Burnout 713
Laura D. Johnson, Alvin L. Reaves III, and
Hunter Groninger
SECTION III
Ethical Considerations in Palliative
Care 725
49. Advance Care Planning, Advance Directives,
and Withholding and Withdrawing
Treatment 726
Hae Lin Cho and Christine Grady
50. Palliative Care: Ethics and the Law 736
Ryan R. Nash and Nicole Shirilla
51. Assisted Suicide or Understanding and
Responding to Requests for Hastened
Death 750
Margaret M. MahonSECTION IV
Special Interventions in Supportive and
Palliative Care 765
52. Hematologic Support of the Cancer
Patient 766
Vanessa Wookey and Lee Schwartzberg
53. Issues in Nutrition and Hydration 785
Elizabeth Kvale and Christine S. Ritchie
54. Complementary and Integrative Therapies in
Oncology 797
Maleeha Ruhi, Karen Baker, and M. Jennifer
Cheng
55. Cannabinoids 821
Sonia Malani, Mary Brown, Jessica Streufert,
and Sunil Kumar Aggarwal
SECTION V
Special Populations 829
56. Geriatric Palliative Care 830
Jessica Israel and R. Sean Morrison
57. Palliative Care in Pediatrics 840
Stacie Stapleton, Valerie A. Cruz Flores,
Anna Sedney, Jasmine Williams, and Laura
Drach
58. Hematopoietic Cell Transplantation and
Supportive Care 879
Nina L. Bray and Ann M. Berger
59. Survivorship Issues in Pediatrics 894
Rebecca Berger and Lynda Kwon Beaupin
60. Survivorship Issues in Adults 911
Rachel Ombres, M. Jennifer Cheng, and
Schuyler C. Cunningham
61. Cancer Genetics and Palliative Care 938
Xiao P . Peng, Ruthann M. Giusti, and Joann
N. Bodurtha
62. Palliative and Supportive Care: The Global
Context 962
Joseph O’Neill and Stephen Connor
SECTION VI
Research Issues in Supportive Palliative
Care 971
63. Outcomes Assessment in Palliative
Care 972
Joan M. Teno
64. Research Issues: Ethics and Study
Design 981
Ryan D. Stephenson, Biren Saraiya, and
Eric A. Singer
Index 991