Khan's Lectures: Handbook of the Physics of Radiation Therapy

Preface vii
CHAPTER 1:
Structure of MatterLecture 1A
Lecture 1B
The Atom . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3Forces of Nature and Fundamental Particles . . . . . . . 7Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11CHAPTER 2:
Nuclear TransformationsLecture 2A
Lecture 2B
Radioactivity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15Nuclear Reactions . . . . . . . . . . . . . . . . . . . . . . . . . . 23Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27CHAPTER 3:
Production of X-RaysLecture 3A
Lecture 3B
X-Ray Tubes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31Physics of X-Ray Production . . . . . . . . . . . . . . . . . . 37Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41CHAPTER 4:
Clinical Radiation GeneratorsLecture 4A
Lecture 4B
X-Ray and Electron Beams . . . . . . . . . . . . . . . . . . . . 45Heavy Particle Accelerators . . . . . . . . . . . . . . . . . . . 55Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60CHAPTER 5:
Interactions of Ionizing RadiationLecture 5A
Lecture 5B
Photon Interactions . . . . . . . . . . . . . . . . . . . . . . . . . 65Particle Interactions . . . . . . . . . . . . . . . . . . . . . . . . . 72Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 CHAPTER 6:
Measurement of Ionizing RadiationLecture 6A
Lecture 6B
Measurement of Exposure . . . . . . . . . . . . . . . . . . . . 81Chambers and Electrometers . . . . . . . . . . . . . . . . . . 87Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92CHAPTER 7:
Quality of X-Ray BeamsLecture 7
Beam Quality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Specification and Measurement of X-Ray97Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102CHAPTER 8:
Measurement of Absorbed DoseLecture 8A
Lecture 8B
Dosimetry Concepts . . . . . . . . . . . . . . . . . . . . . . . 107Dosimeters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119CHAPTER 9:
Dose Distribution and Scatter AnalysisLecture 9
Depth Dose and Tissue-Air Ratios . . . . . . . . . . . . . . 125Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133CHAPTER 10:
A System of Dosimetric CalculationsLecture 10
Formalism for Monitor Units Calculation . . . . . . . 139Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148CHAPTER 11:
Distributions
Treatment Planning I: IsodoseLecture 11
Isodose Distribution and Plan Evaluation . . . . . . . 153Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170CHAPTER 12:
Corrections, and Setup
Treatment Planning II: Patient Data,Lecture 12A
Treatment Verification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lecture 12B:
Inhomogeneities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Patient Data Acquisition, Simulation, and175Corrections for Irregular Surface and Tissue183Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 190 Contents
xiCHAPTER 13:
Skin Dose, and Field Separation
Treatment Planning III: Field Shaping,Lecture 13
Field Separation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Field Shaping, Surface Dose, and195Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204CHAPTER 14:
Electron Beam TherapyLecture 14A
Lecture 14B
Electron Beam Interactions and Dosimetry . . . . . 209Electron Beam Treatment Planning . . . . . . . . . . . 220Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 234CHAPTER 15:
BrachytherapyLecture 15
Implantation and Dose Specification . . . . . . . . . . . . . . . . . . .
Low-Dose-Rate Brachytherapy: Rules of239Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249CHAPTER 16:
Radiation ProtectionLecture 16
Radiation Protection and Shielding Design . . . . . . 253Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261CHAPTER 17:
Quality AssuranceLecture 17
Quality Assurance and Maintenance . . . . . . . . . . . . 267Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273CHAPTER 18:
Total Body IrradiationLecture 18
and Dosimetry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Total Body Irradiation: Techniques277Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 282CHAPTER 19:
Radiation Therapy
Three-Dimensional ConformalLecture 19
Treatment Planning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3D Conformal Radiotherapy: Dosimetry and287Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295xii
ContentsCHAPTER 20:
Intensity-Modulated Radiation TherapyLecture 20
and Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
IMRT: Commissioning, Treatment Planning,299Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 308CHAPTER 21:
Stereotactic Radiation TherapyLecture 21
Stereotactic Radiotherapy and Radiosurgery . . . . . . 313Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 320CHAPTER 22:
High-Dose-Rate BrachytherapyLecture 22
Treatment Planning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
High-Dose-Rate Brachytherapy: Dosimetry and325Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330CHAPTER 23:
Prostate ImplantsLecture 23
Treatment Planning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Prostate Implants: Technique, Dosimetry, and335Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 343CHAPTER 24:
Intravascular BrachytherapyLecture 24
and Dosimetry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Intravascular Brachytherapy: Techniques347Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 352CHAPTER 25:
Image-Guided Radiation TherapyLecture 25
Tracking, and Imaging Dose . . . . . . . . . . . . . . . . . . . . . . . . .
IGRT: On-Board Imagers, Online Tumor355Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 364CHAPTER 26:
Proton Beam TherapyLecture 26
Treatment Planning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Proton Beam Therapy: Dosimetry and367Review Questions
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377Answers
Index 383
379/B>/B>

--20-30 practice questions (a mix of problems and multiple choice questions) will be provided at the end of each chapter, with answer keys, hints, and explanations for each question at the end of the book
--4-color diagrams (new as well as from the primary text)
--Good complement to Physics of Radiation Therapy
--Great for board review as well as recertification