Contributors vii 
Preface xiii 
Preface to the First Edition xv
SECTION I
Treatment Planning: Safety and Biological 
Principles 1
CHAPTER 1 Patient Safety 2
 Lukasz M. Mazur, Lawrence B. Marks, Shiva Das, 
Ross  McGurk, Karthik Adapa, Alison N. Amos, 
Deen Gu, Bret Shultz, and Bhisham Chera
CHAPTER 2 Normal Tissue Tolerance 26
 Dominic H. Moon and Robert D. Timmerman
CHAPTER 3 Fractionation: Radiobiologic  Principles and 
Clinical Practice 41
 Colin Orton
CHAPTER 4 Immunologic Principles of Treatment Planning: 
Radiation as In Situ  Vaccine and Dose 
Fractionation in the  Immunotherapy Era 56
 Andrew Brandmaier
SECTION II
Treatment Planning: Site-Specific 
 Cancers 67
CHAPTER 5  Cancers of the Central Nervous  System 68
 Vinai Gondi, Paul W. Sperduto, and  
Minesh P. Mehta
CHAPTER 6  Cancers of the Head and Neck 87
 Yolanda I. Garces, Charles Mayo,  Christopher Beltran, 
and Robert L. Foote
CHAPTER 7  Cancers of the Thorax/Lung 108
 Gregory M.M. Videtic, Rupesh Kotecha,  
Neil M. Woody, and Kevin L. Stephans
CHAPTER 8  Breast Cancer 134
 Susan G.R. McDuff, Colin E. Champ, Sua Yoo, and 
Rachel C. Blitzblau
CHAPTER 9  Cancers of the Gastrointestinal Tract 155
 David Carpenter, Jordan Torok,  Christopher G. Willett, 
Fang-Fang Yin, and Brian G. Czito
CHAPTER 10  Cancer of the Genitourinary Tract:  Prostate, 
Bladder, and Testicular  Cancer 189
 Stephanie M. Yoon, Andrew S. Lim, and Albert Chang
CHAPTER 11  Gynecologic Malignancies 240
 Aaron B. Simon, Daniel R.  Simpson, Loren K. Mell, 
 Dominique Rash, Jyoti Mayadev, Arno J. Mundt,  and 
Catheryn M. Yashar
CHAPTER 12  The L ymphomas 269
 John P. Plastaras, Stefan Both, and Ima Paydar
CHAPTER 13  Cancers of the Skin, Including Mycosis 
Fungoides 284
 Zhe (Jay) Chen, James C. L. Chow,  Alexander Sun, 
Himanshu Nagar, Kenneth R. Stevens Jr., and  
Jonathan P. S. Knisely
CHAPTER 14  Pediatric Malignancies 309
 Myrsini Ioakeim–Ioannidou, Shannon M. MacDonald, 
and Nancy J. Tarbell
CHAPTER 15  Soft Tissue and Bone Sarcoma 330
 Kilian E. Salerno, Yen-Lin Chen, Thomas F. DeLaney, 
and Elizabeth H. Baldini
SECTION III
Treatment Planning: Physics and Dosimetric 
Principles 365
CHAPTER 16  Introduction: Process, Equipment, and 
Personnel 366
 Faiz M. Khan and John P. Gibbons
CHAPTER 17  Image-Guided Radiation  Therapy 374
 Guang Li, Gig S. Mageras, Lei Dong, and  
Radhe Mohan
CHAPTER 18  Deformable Image Registration 404
 Raj Varadhan
CHAPTER 19  P atient Simulation 420
 Dimitris N. Mihailidis and Niko  Papanikolaou
CHAPTER 20 Treatment Planning Algorithms: Photon Dose 
Calculations 437
 John P. Gibbons
CHAPTER 21 Treatment Planning Algorithms: 
 Brachytherapy 452
 Kenneth J. Weeks
CHAPTER 22 Treatment Planning Algorithms:  Electron 
Beams 467
 Kenneth R. Hogstrom, Garrett M. Pitcher,   
Robert L. Carver, and John A. Antolak
ContentsCHAPTER 23 Treatment Planning Algorithms:  Proton 
Therapy 496
 Hanne M. Kooy, Benjamin M. Clasie,  
and  Nicolas Depauw
CHAPTER 24 Commissioning and Quality  Assurance 507
 Francisco J. Reynoso and James A.  Kavanaugh
CHAPTER 25 Intensity-Modulated Radiation Therapy: 
Photons 528
 Jan Unkelbach
CHAPTER 26 Patient and Organ Movement 560
 Paul J. Keall and James M. Balter
CHAPTER 27 Linac Radiosurgery: System Requirements, 
Procedures, and Testing 570
 Frank J. Bova, William A. Friedman,  
and  Jonathan G. Li
CHAPTER 28 Stereotactic Ablative Radiotherapy 595
 Mu-Han Lin, Andrew Godley, and  
Robert D. Timmerman
CHAPTER 29 Low Dose-Rate Brachytherapy 613
 Yun Yang and Mark J. Rivard
CHAPTER 30 High-Dose-Rate Brachytherapy Treatment 
Planning 629
 Bruce R. Thomadsen, Jessica Miller,  Poonam Yadav, 
and Susan Richardson
CHAPTER 31 Electron Beam Treatment Planning 665
 John A. Antolak
CHAPTER 32 Proton Beam Therapy 690
 Hanne M. Kooy, Judith Adams,  
and Nicolas Depauw
CHAPTER 33 Treatment Plan Evaluation 704
 Ellen D. Yorke, Andrew Jackson,  
and  Gerald J. Kutcher
CHAPTER 34 Knowledge-Based T reatment  Planning 722
 Todd R. McNutt, John P. Gibbons, and  Binbin Wu
Index 735