PART ONE ¦ Critical Care Integration
SECTION I ¦ Introduction to the Practice of Pediatric Critical Care
Chapter 1 Pediatric Intensive Care: A Global Perspective
Trevor Duke, Niranjan “Tex” Kissoon, and Edwin Van Der Voort
Chapter 2 Impact of Pediatric Critical Care on the Family, Community, and Society
Lewis H. Romer, David G. Nichols, Jessica Mesman, Heather Woods Barthel, Matt Norvell, Melissa J. Sacco, Khaliah Johnson, and Jos M. Latour

SECTION II ¦ PROFESSIONALISM, LEADERSHIP, AND SYSTEMS-BASED PRACTICE
Chapter 3 Professionalism and Leadership in Pediatric Critical Care
Vinay M. Nadkarni and Alice D. Ackerman
Chapter 4 Simulation Training and Team Dynamics
Elizabeth A. Hunt, David Grant, and Michael Rosen
Chapter 5 PICU Organization and Physical Design
M. Michele Moss and Shari Simone
Chapter 6 Practice Management: The Business of Pediatric Critical Care
Meredith G. Van Der Velden and Jeffrey P. Burns
Chapter 7 Research Design and Statistical Analysis
Wynne E. Morrison, Elizabeth A. Hunt, J. Michael Dean, and Anne-Marie Guerguerian
Chapter 8 Evidence-Based Medicine
Barry P. Markovitz and Kathleen L. Meert
Chapter 9 Quality Improvement, Patient Safety, and Medical Error
Andrew C. Argent and Vicki L. Montgomery

SECTION III ¦ INFORMATION MANAGEMENT
Chapter 10 Severity-of-Illness Measurement: Foundations, Principles, and Applications
Anthony D. Slonim, James P. Marcin, and Murray M. Pollack
Chapter 11 Communication and Information Technology in the PICU
Steven Pon and Barry P. Markovitz
Chapter 12 Learning from the Data—Discovery Informatics for Critically Ill Children
Randall C. Wetzel

SECTION IV ¦ Ethical and Palliative Concerns in the Care of the Critically Ill
Chapter 13 Integrating Palliative Care and Critical Care
Wynne E. Morrison, Patricia Lago, Jefferson Pedro Piva, and Kathleen L. Meert
Chapter 14 Pain and Sedation Management
Sapna R. Kudchadkar, R. Blaine Easley, Kenneth M. Brady, and Myron Yaster
Chapter 15 Ethics
George E. Hardart and Denis J. Devictor
Chapter 16 Organ Donation
Kristen L. Nelson McMillan, Thomas A. Nakagawa, and Ivor D. Berkowitz
Chapter 17 Rehabilitation
Melissa K. Trovato, Glendaliz Bosques, Robert J. Graham, Megan E. Kramer, Frank S. Pidcock, Suzanne V. Prestwich, Cristina L. Sadowsky, and Scott C. Schultz

Section V ¦ Basic Science Concepts of Pediatric Critical Care
Chapter 18 Omics and Critical Care
Mary K. Dahmer and Michael Quasney
Chapter 19 Innate Immunity and Inflammation
James A. Thomas
Chapter 20 Cellular Adaptations to Stress
Derek S. Wheeler and Hector R. Wong
Chapter 21 Shock, Ischemia, and Reperfusion Injury
Basilia Zingarelli
Chapter 22 Pharmacology
Athena F. Zuppa
Chapter 23 Multiple Organ Dysfunction Syndrome
Scott L. Weiss, Yong Y. Han, Thomas P. Shanley, and Joseph A. Carcillo

PART TWO ¦ EMERGENCY CARE AND ACUTE MANAGEMENT
SECTION I ¦ INITIAL STABILIZATION
Chapter 24 Airway Management
Dominic Cave, Jonathan P. Duff, Allan De Caen, and Mary Fran Hazinski
Chapter 25 Cardiopulmonary Resuscitation
Robert A. Berg, Katsuyuki Miyasaka, Antonio Rodríguez-Núñez, Mary Fran Hazinski, David Anthony Zideman, and Vinay M. Nadkarni
Chapter 26 Stabilization and Transport
Monica E. Kleinman, Aaron J. Donoghue, Richard A. Orr, and Niranjan “Tex” Kissoon
Chapter 27 Invasive Procedures
Stephen M. Schexnayder, Praveen Khilnani, and Naoki Shimizu
Chapter 28 Recognition and Initial Management of Shock
Ruchi Sinha, Simon Nadel, Niranjan “Tex” Kissoon, and Suchitra Ranjit
Chapter 29 Rapid Response Systems
Christopher P. Bonafide, Richard J. Brilli, James Tibballs, Christopher S. Parshuram, Patrick W. Brady, and Derek S. Wheeler

SECTION II ¦ Environmental Crises
Chapter 30 Multiple Trauma
John Scott Baird and Arthur Cooper
Chapter 31 Drowning
Katherine V. Biagas and Linda Aponte-Patel
Chapter 32 Burns and Smoke Inhalation
Roger W. Yurt, James J. Gallagher, Joy D. Howell, and Bruce M. Greenwald
Chapter 33 Injury From Chemical, Biologic, Radiologic, and Nuclear Agents
Peter Silver, F. Meridith Sonnett, and George L. Foltin
Chapter 34 Mass Casualty Events
Maria Cristina Esperanza
Chapter 35 Poisoning
Michael A. Nares, G. Patricia Cantwell, and Richard S. Weisman
Chapter 36 Thermoregulation
Adnan M. Bakar and Charles L. Schleien
Chapter 37 Envenomation Syndromes
James Tibballs and Kenneth D. Winkel

SECTION III ¦ LIFE-SUPPORT TECHNOLOGIES
Chapter 38 Mechanical Ventilation
Mark J. Heulitt, Courtney Ranallo, Gerhard K. Wolf, and John H. Arnold
Chapter 39 Inhaled Gases and Noninvasive Ventilation
Angela T. Wratney, Donna S. Hamel, Ira M. Cheifetz, and David G. Nichols
Chapter 40 Extracorporeal Life Support
Graeme Maclaren, Steven A. Conrad, and Heidi J. Dalton
Chapter 41 Extracorporeal Organ Support Therapy
Warwick W. Butt, Peter W. Skippen, Phillippe Jouvet, and Jim Fortenberry
Chapter 42 Blood Products and Transfusion Therapy
Oliver Karam, Philip C. Spinella, Edward C.C. Wong, and Naomi L.C. Luban

PART THREE ¦ CRITICAL CARE ORGAN SYSTEMS
SECTION I ¦ RESPIRATORY DISEASE
Chapter 43 Respiratory Physiology
Frank L. Powell, Gregory P. Heldt, and Gabriel G. Haddad
Chapter 44 The Molecular Biology of Acute Lung Injury
Todd Carpenter and Kurt R. Stenmark
Chapter 45 Respiratory Monitoring
Ira M. Cheifetz, Jan Hau Lee, and Shekhar T. Venkataraman
Chapter 46 Status Asthmaticus
Michael T. Bigham and Richard J. Brilli
Chapter 47 Neonatal Respiratory Failure
Narayan Prabhu Iyer, Philippe S. Friedlich, Elisabeth L. Raab, Rangasamy Ramanathan, and Istvan Seri
Chapter 48 Pneumonia and Bronchiolitis
Werther Brunow De Carvalho, Marcelo Cunio Machado Fonseca, Cintia Johnston, and David G. Nichols
Chapter 49 Acute Lung Injury and Acute Respiratory Distress Syndrome
Kathleen M. Ventre and John H. Arnold
Chapter 50 Chronic Respiratory Failure
Thomas G. Keens, Sheila S. Kun, and Sally L. Davidson Ward
Chapter 51 Sleep and Breathing
Sally L. Davidson Ward and Thomas G. Keens

SECTION II ¦ NEUROMUSCULAR DISEASE
Chapter 52 Electrodiagnostic Techniques in Neuromuscular Disease
Matthew Pitt
Chapter 53 Acute Neuromuscular Disease
Sunit C. Singhi, Naveen Sankhyan, and Arun Bansal
Chapter 54 Chronic Neuromuscular Disease
Elena Cavazzoni, Jonathan Gillis, and Monique M. Ryan

SECTION III ¦ NEUROLOGIC DISEASE
Chapter 55 Developmental Neurobiology, Neurophysiology, and the PICU
Larry W. Jenkins and Patrick M. Kochanek
Chapter 56 Molecular Biology of Brain Injury
Patrick M. Kochanek, Hülya Bayir, Larry W. Jenkins, and Robert S.B. Clark
Chapter 57 Evaluation of the Comatose Child
Nicholas S. Abend and Daniel J. Licht
Chapter 58 Neurologic Monitoring
Robert C. Tasker, Mateo Aboy, Alan Graham, and Brahm Goldstein
Chapter 59 Neurologic Imaging
David J. Michelson and Stephen Ashwal
Chapter 60 Neurosurgical and Neuroradiological Critical Care
Michael L. McManus, Craig D. McClain, and Robert C. Tasker
Chapter 61 Head and Spinal Cord Trauma
Robert C. Tasker and P. David Adelson
Chapter 62 Abusive Head Trauma
Rachel P. Berger, Dennis Simon, Jennifer E. Wolford, and Michael J. Bell
Chapter 63 Status Epilepticus
Kimberly S. Bennett and Colin B. Van Orman
Chapter 64 Cerebrovascular Disease and Stroke
John Pappachan, Robert C. Tasker, and Fenella Kirkham
Chapter 65 Hypoxic–Ischemic Encephalopathy
Ericka L. Fink, Mioara D. Manole, and Robert S.B. Clark
Chapter 66 Metabolic Encephalopathies in Children
Laurence Ducharme-Crevier, Genevieve Dupont-Thibodeau, Anne Lortie, Bruno Maranda, Robert C. Tasker, and Philippe Jouvet
Chapter 67 The Determination of Brain Death
Thomas A. Nakagawa and Mudit Mathur

Section IV ¦ Cardiovascular Disease
Chapter 68 Cardiac Anatomy
Steven M. Schwartz, Zdenek Slavik, and Siew Yen Ho
Chapter 69 Cardiovascular Physiology
Peter Oishi, Rebecca Johnson Kameny, Julien I. Hoffman, and Jeffrey R. Fineman
Chapter 70 Cardiorespiratory Interactions in Children with Heart Disease
Ronald A. Bronicki and Lara S. Shekerdemian
Chapter 71 Hemodynamic Monitoring
Ronald A. Bronicki and Neil C. Spenceley
Chapter 72 Heart Failure: Etiology, Pathophysiology, and Diagnosis
Mary E. McBride, John M. Costello, and Conrad L. Epting
Chapter 73 Cardiomyopathy, Myocarditis, and Mechanical Circulatory Support
William G. Harmon, Aparna Hoskote, and Ann Karimova
Chapter 74 Treatment of Heart Failure: Medical Management
Joseph W. Rossano, Jack F. Price, and David P. Nelson
Chapter 75 Treatment of Heart Failure: Mechanical Support
Iki Adachi, Lara Shekerdemian, Paul A. Checchia, and Charles D. Fraser Jr
Chapter 76 Thoracic Transplantation
Steven A. Webber, Laura L. Loftis, Aarti Bavare, Renee M. Potera, and Nikoleta S. Kolovos
Chapter 77 Cardiac Conduction, Dysrhythmias, and Pacing
Richard J. Czosek, David S. Spar, Jeffrey B. Anderson, Timothy K. Knilans, and Bradley S. Marino
Chapter 78 Preoperative Care of the Pediatric Cardiac Surgical Patient
Jennifer J. Schuette, Alain Fraisse, and David L. Wessel
Chapter 79 Postoperative Care of the Pediatric Cardiac Surgical Patient
Ronald A. Bronicki, John M. Costello, and Kate L. Brown
Chapter 80 Pulmonary Hypertension
John K. McGuire, Silvia M. Hartmann, and Apichai Khongphatthanayothin

Section V ¦ Immunologic Diseases
Chapter 81 The Immune System
Rachel S. Agbeko, Nigel J. Klein, and Mark J. Peters
Chapter 82 Neurohormonal Control in the Immune System
Kathryn A. Felmet
Chapter 83 The Polymorphonuclear Leukocyte in Critical Illness
M. Michele Mariscalco
Chapter 84 The Immune System and Viral Illness
Lesley Doughty
Chapter 85 Immune Modulation and Immunotherapy in Critical Illness
Mark W. Hall and Jennifer A. Muszynski
Chapter 86 Immune Deficiency Disorders
Tracy B. Fausnight, E. Scott Halstead, Sachin S. Jogal, and Jennifer A. McArthur

Section VI ¦ Infectious Diseases
Chapter 87 Bacterial Sepsis
Neal J. Thomas, Robert F. Tamburro, Surender Rajasekaran, Julie C. Fitzgerald, Scott L. Weiss, and Mark W. Hall
Chapter 88 Principles of Antimicrobial Therapy
Cheryl L. Sargel, Todd J. Karsies, Lulu Jin, and Kevin B. Spicer
Chapter 89 Dengue and Other Hemorrhagic Viral Infections
Siripen Kalayanarooj and Rakesh Lodha
Chapter 90 Critical Viral Infections
Rakesh Lodha, Sunit C. Singhi, and James D. Campbell
Chapter 91 Central Nervous System Infections
Pratibha D. Singhi and Sunit C. Singhi
Chapter 92 Nosocomial Infections in the PICU
Jason W. Custer, Jill S. Thomas, and John P. Straumanis
Chapter 93 International and Emerging Infections
Troy E. Dominguez, Chitra Ravishankar, Miriam K. Laufer, and Mark W. Hall
Chapter 94 Toxin-Related Diseases
Sunit C. Singhi, M. Jayashree, John P. Straumanis, and Karen L. Kotloff
Chapter 95 Opportunistic Infections
Sushil K. Kabra and Matthew B. Laurens

Section VII ¦ NUTRITIONAL AND GASTROINTESTINAL DISORDERS
Chapter 96 Principles of Gastrointestinal Physiology, Nutrition, and Metabolism
Patrick O’Neal Maynord and Z. Leah Harris
Chapter 97 Nutritional Support
Werther Brunow De Carvalho, Artur F. Delgado, and Heitor Pons Leite
Chapter 98 Secretory and Motility Issues of the Gastrointestinal Tract
Eitan Rubinstein and Samuel Nurko
Chapter 99 Gastrointestinal Bleeding
Sabina Mir and Douglas S. Fishman
Chapter 100 Abdominal Compartment Syndrome
Mudit Mathur and Janeth C. Ejike
Chapter 101 The Acute Abdomen
Eduardo J. Schnitzler, Tomas Iölster, and Ricardo D. Russo
Chapter 102 Diagnostic Imaging of the Abdomen
Swapnil S. Bagade and Rebecca Hulett Bowling
Chapter 103 Acute Liver Failure and Liver Transplantation
Pierre Tissieres and Denis J. Devictor Chapter
104 Pediatric Intestinal and Multivisceral Transplantations
Geoffrey J. Bond, Kathryn A. Felmet, Ronald Jaffe, Kyle A. Soltys, Jeffrey A. Rudolph, Dolly Martin, Rakesh Sindhi, and George V. Mazariegos

Section VIII ¦ RENAL, ENDOCRINE, AND METABOLIC DISORDERS
Chapter 105 Adrenal Dysfunction
Abeer Hassoun and Sharon E. Oberfield
Chapter 106 Disorders of Glucose Homeostasis
Edward Vincent S. Faustino, Stuart A. Weinzimer, Michael F. Canarie, and Clifford W. Bogue
Chapter 107 Disorders of Water, Sodium, and Potassium Homeostasis
James Schneider and Andrea Kelly
Chapter 108 Disorders of Calcium, Magnesium, and Phosphate
Kenneth J. Banasiak
Chapter 109 Thyroid Disease
Ori Eyal and Susan R. Rose
Chapter 110 Acute Kidney Injury
Christine B. Sethna, Nataliya Chorny, Smarika Sapkota, and James Schneider
Chapter 111 Chronic Kidney Disease, Dialysis, and Renal Transplantation
Vinai Modem, Robert P. Woroniecki, and Fangming Lin
Chapter 112 Hypertensive Crisis
George Ofori-Amanfo, Arthur Smerling, and Charles L. Schleien
Chapter 113 Inborn Errors of Metabolism
Michael Wilhelm and Wendy K. Chung

Section IX ¦ Oncologic and Hematologic Disorders
Chapter 114 Cancer Therapy: Mechanisms and Toxicity
David M. Loeb and Masanori Hayashi
Chapter 115 Oncologic Emergencies and Complications
Rodrigo Mejia, Nidra I. Rodriguez, Jose A. Cortes, Sanju S. Samuel, Fernando F. Corrales-Medina, Regina Okhuysen, Riza C. Mauricio, and Winston W. Huh
Chapter 116 Hematologic Emergencies
Michael C. McCrory, Kenneth M. Brady, Clifford M. Takemoto, and R. Blaine Easley
Chapter 117 Hematopoietic Cell Transplantation
Monica Bhatia and Katherine V. Biagas
Chapter 118 Coagulation Issues in the PICU
Robert I. Parker and David G Nichols
Chapter 119 Sickle Cell Disease
Kevin J. Sullivan, Erin Coletti, Salvatore R. Goodwin, Cynthia Gauger, and Niranjan “Tex” Kissoon

Appendix A1