Home / Medicine / Pizzo & Poplack's Pediatric Oncology
9781975124793
ISBN/ISSN
9781975124793
Publication Date
August 25, 2020
2020-08-25
Availability
IN STOCK
9781975124793
Preview link
Rights Link
$ 399.99 USD $399.99
*Final price may vary based on conversion rate.
Quantity

Buy from another retailer

Sorry! Promocode will not apply for this product.

  • Description
    Selected as a Doody's Core Title for 2021!

    Comprehensive, authoritative, and up to date, Pizzo and Poplack’s Pediatric Oncology, 8th Edition, remains your most trusted source of information on the care and research of children with cancer. This award-winning text is the single most comprehensive reference on the biology and genetics of childhood cancer, its diagnosis and multimodal treatment, and long-term management. In the tradition of excellence established by Drs. Philip A. Pizzo and David G. Poplack, this 8th Edition keeps you fully informed while helping you collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families.
    • Covers all aspects of the breadth and depth of childhood cancer, including basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy.
    • Includes updates to current treatment approaches based on the results of recently completed and published clinical research.
    • Contains new information on the biology of pediatric malignancies and strategies for the conduct of clinical trials that reflect the rapid pace of laboratory discovery.
    • Features chapters on palliative care and education, and covers supportive care in contexts such as emergencies, infectious disease, and nutrition.
    • Provides expert guidance on state-of-the-art, multidisciplinary care for children and families, including psychosocial aspects of care and perspectives from patients and parents.
    • Discusses the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia. 
    Enrich Your eBook Reading Experience
    • Read directly on your preferred device(s), such as computer, tablet, or smartphone.
    • Easily convert to audiobook, powering your content with natural language text-to-speech.
  • Specs
    Edition
    8
    ISBN/ISSN
    9781975124793
    Product Format
    HC-Printed Cover
    Trim Size
    8.375 x 10.875
    Pages
    1352
    Illustration
    463
    Edition
    8
    Publication Date
    August 25, 2020
    Weight
    7.3
  • Susan M. Blaney MD
    Texas Children's Hospital
    Houston, Texas
    Lee J. Helman MD
    Children's Hospital of Los Angeles
    Los Angeles, California
    Peter C. Adamson MD
    The Children's Hospital of Philadelphia
    Philadelphia, PA
  • Table of contents
    Contents
    SECTION 1
    Biological Basis of Childhood Cancer
    1 Epidemiology of Childhood Cancer 1
    Michael E. Scheurer, Philip J. Lupo, Joachim Schüz,
    and Logan G. Spector
    Cancer Surveillance and Descriptive Epidemiology 1
    Analytic Epidemiology 7
    Summary and Future Considerations 12
    2 Heredity and Childhood Cancer 15
    David Malkin, Sharon E. Plon, Joshua D. Schiffman,
    Christian P. Kratz, and Thierry Frebourg
    Constitutional Chromosomal Abnormalities 15
    Structural Chromosomal Abnormalities 16
    Overgrowth Disorders and Imprinting Errors 17
    Autosomal Dominant Disorders 18
    Autosomal Recessive Disorders 27
    Issue in Genetic Testing for the Pediatric
    Oncology Patient 30
    3 Molecular and Genetic Basis of Childhood
    Cancer 34
    Peter D. Aplan, Jack F. Shern, and Javed Khan
    General Nature of Cancer-Associated Genetic
    Aberrations 34
    Comprehensive Analysis of the Cancer Genome 34
    Germline Mutations 39
    Somatically Acquired Chromosomal Aberrations
    and Mutation 42
    Gross Chromosomal Rearrangements 42
    Oncogenic Consequences of Gross Chromosomal
    Rearrangements—General Themes 43
    Chromosomal Translocations Lead to Activation of
    Proto-Oncogenes and Generation of Oncogenic
    Fusion Genes 44
    Chromosomal Deletion Leads to Inactivation of Tumor
    Suppressor Genes 51
    Gene Amplification 53
    Point Mutations Leading to Gene Activation or
    Inactivation 53
    Comprehensive Genomic Studies of Pediatric
    Tumors 54
    Mechanisms of Malignant Cell Transformation, Growth,
    and Clonal Expansion 57
    Outlook for Molecularly Targeted Therapies 59
    Summary 61
    4 Biology of Childhood Cancer 66
    Tanja Andrea Gruber and Elizabeth R. Lawlor
    Gene Regulation 66
    Protein Regulation 70
    Signal Transduction 71
    Cell Proliferation 74
    Programmed Cell Death 76
    Cancer Metabolism 79
    Metastasis and the Tumor Microenvironment 82
    5 Tumor Immunology of Childhood Cancer 87
    Terry J. Fry, Paul M. Sondel, and Crystal L. Mackall
    Overview of the Immune System 87
    Modern Concepts of Immune Surveillance 91
    T-Cell Recognition of Cancer 92
    Innate Immune Cells and the Tumor
    Microenvironment 93
    Immune Function in Cancer Patients 93
    Immunotherapy of Cancer 94
    Summary and Future Directions 100
    SECTION 2
    Diagnosis and Evaluation of the Child
    with Cancer
    6 Clinical Assessment and Differential
    Diagnosis of Suspected Childhood
    Cancer 105
    Wendy Allen-Rhoades and Charles Philip Steuber
    Children at Risk 106
    Time to Diagnosis 106
    Differential Diagnosis 106
    Establishing the Diagnosis 113
    Summary 113
    7 Pathology and Molecular Diagnosis of
    Leukemias and Lymphomas 117
    Elizabeth Margolskee, Gerald Benjamin Waith Wertheim, and
    Richard C. Harvey
    Introduction 117
    Ancillary Studies 117
    Lymphoblastic Leukemia 119
    Myeloid Neoplasms 121
    Mature Lymphoid Neoplasms 125
    Histiocytic Disorders 128
    8 Diagnostic Pathology of Pediatric Solid and
    Central Nervous System Malignancies 131
    Timothy J. Triche, Thomas G. P. Grünewald,
    Jennifer Cotter, Matthew C. Hiemenz, Andrey Korshunov,
    M. John Hicks, and Poul H. Sorensen
    Introduction 131
    Brief Pathologic Classification of Pediatric Solid
    Tumors 133
    Traditional Approaches to Childhood Solid Tumor
    Diagnosis 134
    Molecular Genetic Evaluation of
    Childhood Cancer 146
    Integrated Diagnostic Molecular Pathology of Pediatric
    Solid Tumors 151
    The Holistic Cancer Genome 169
    DNA 169
    RNA 170
    Emerging Technologies for Diagnosis 170
    The Future of Pediatric Cancer Diagnosis 172 9 Imaging Studies in the Diagnosis of
    Childhood Cancer 184
    Rajesh Krishnamurthy, Heike E. Daldrup-Link, Jeremy Y. Jones,
    Stephan D. Voss, Adam J. Bobbey, Garima Suman, and
    Ellen M. Chung
    Relative Merits of Available Imaging Procedures 184
    General Concepts of Pediatric Tumor Imaging 197
    Future Directions 233
    SECTION 3
    Principles of Multimodal Therapy
    10 General Principles of Chemotherapy 239
    Elizabeth Fox, Susan M. Blaney, Lucas Moreno, Robin Norris,
    Jeffrey M. Skolnik, Peter C. Adamson, and Frank M. Balis
    Principles of Cancer Chemotherapy 239
    Clinical Pharmacology of Anticancer Drugs 241
    Alkylating Agents 255
    Nonclassical Alkylating Agents 261
    Antimetabolites 265
    Purine Antimetabolites 268
    Pyrimidine Antimetabolites 271
    Topoisomerase Inhibitors 274
    Tubulin Inhibitors 280
    Miscellaneous Agents 282
    Small-Molecule Pathway Inhibitors 287
    Therapeutic Antibodies 291
    Perspectives 293
    11 General Principles of Cellular
    Immunotherapy 303
    Meenakshi G. Hegde, Shoba A. Navai, Sujith K. Joseph,
    Andras Heczey, Stephen Gottschalk, Cliona M. Rooney, and
    Malcolm K. Brenner
    T Cells 303
    Natural Killer Cells 318
    gd Thymus-Derived T Cells 318
    Invariant Natural Killer T Cells 318
    Strategies to Improve Adoptive Cellular Therapies 319
    Conclusions 321
    12 General Principles of Targeted Therapy 327
    Julia Glade Bender, Maria Luisa Sulis, and Malcolm A. Smith
    Introduction 327
    Basic Principles for the Clinical Development of
    Molecularly Targeted Agents 327
    Therapies Targeted to Apoptosis Pathways 338
    Targeting Extracellular Survival Signaling Pathways 340
    Targeting Development, Differentiation, and Other
    Intracellular Processes 348
    Targeting Angiogenesis 351
    Conclusions 352
    13 General Principles of Hematopoietic Stem
    Cell Transplantation 362
    Michael A. Pulsipher, Swati Naik, and Helen E. Heslop
    Autologous Transplantation—High-Dose Chemotherapy
    with Hematopoietic Stem Cell (HSC) Rescue 362
    Allogeneic Transplantation 362
    Allogeneic Hematopoietic Stem Cell Transplantation
    Preparative Regimens 364
    Transplantation for Leukemia 365
    Transplantation for Hodgkin Lymphoma (HL) and
    Non-Hodgkin Lymphoma (NHL) 372
    Transplantation for Solid Tumors 374
    Complications After Hematopoietic Stem Cell
    Transplantation 375
    Late Effects After Hematopoietic Stem Cell
    Transplantation 378
    Future Directions 379
    14 General Principles of Radiation
    Oncology 385
    Colette J. Shen, Ralph P. Ermoian, Shannon E. Fogh,
    Steve E. Braunstein, Kavita K. Mishra, Daphne A. Haas-Kogan,
    and Stephanie A. Terezakis
    Biologic Basis of Radiation Therapy 385
    Physical Basis of Radiation Therapy 387
    Interactions of Radiation Therapy and
    Chemotherapy 393
    Radiation Effects on Normal Tissues 394
    15 General Principles of Surgery 405
    Sanjeev A. Vasudevan, Richard S. Whitlock, Christopher B.
    Weldon, and Jed G. Nuchtern
    Preoperative Considerations for the Oncologist 405
    Perioperative Considerations for the Oncologist 411
    Minimally Invasive Surgery 414
    SECTION 4
    Management of Common Cancers of
    Childhood
    16 Acute Lymphoblastic Leukemia 419
    M. Monica Gramatges, Maureen M. O’Brien, and Karen R. Rabin
    Epidemiology 419
    Genetic Risk Factors 420
    Environmental Risk Factors 421
    Pathogenesis 422
    Classification of Acute Lymphoblastic Leukemia 422
    Molecular Genomics of Acute Lymphoblastic
    Leukemia 423
    Pharmacogenetics 431
    Clinical Presentation 432
    Assessing Treatment Response 435
    Prognostic Factors 435
    Treatment 438
    Treatment of Relapse 444
    Late Effects of Treatment 445
    Future Challenges 447
    17A Acute Myeloid Leukemia and Myelodysplastic
    Syndromes 454
    Richard Aplenc, Caitlin W. Elgarten, John Kim Choi,
    and Soheil Meshinchi
    Historical Background and Definitions 454
    Epidemiology of Pediatric Acute Myeloid Leukemia and
    Myelodysplastic Syndrome 454
    Biologic Basis of Acute Myeloid Leukemia and
    Myelodysplastic Syndrome: From Normal Progenitors
    to Leukemia 455
    Methodologies for Classifying Myeloid
    Malignancies 460
    Defining Subtypes: Evolution of Diagnostic Classification
    of Myeloid Malignancies 463
    Clinical and Laboratory Presentation 467
    Prognostic Factors and Implications of Risk Group
    Stratification on Treatment 470
    Evolution of Risk Adapted Therapy 474
    Unique AML Subtypes and Settings 483
    The Treatment of Relapsed or Refractory Acute
    Myeloid Leukemia 484
    Survivorship 486
    17B Myeloproliferative Neoplasms
    of Childhood 496
    Rachel E. Rau and Mignon L. Loh
    Chronic Myeloid Leukemia 496
    Juvenile Myelomonocytic Leukemia 508
    Polycythemia Vera and Essential Thrombocythemia 511 18 Hodgkin Lymphoma 517
    Peter D. Cole, Rahul R. Parikh, and Kara M. Kelly
    Biologic Considerations 517
    Epidemiology, Pathogenesis & Pathology 518
    Clinical Presentation 520
    Treatment and Outcome 523
    Nodular Lymphocyte Predominant Hodgkin
    Lymphoma 528
    Approach to Patients with Primary Refractory Disease or
    Relapse of Hodgkin Lymphoma 530
    Late Effects 531
    Future Considerations 534
    19 Malignant Non–Hodgkin Lymphomas in
    Children 538
    Thomas G. Gross, Kala Y. Kamdar, and Catherine M. Bollard
    Non-Hodgkin Lymphoma Overview 538
    NHL Cellular Classifications: Specific Biologic and Clinical
    Considerations 540
    Conclusions 550
    Management Summary 550
    20 Lymphoproliferative Disorders
    and Malignancies Related to
    Immunodeficiencies 554
    David T. Teachey
    Viral Pathogens and the Development of
    Malignancies 554
    Epstein–Barr Virus and Malignancies 554
    Human herpesvirus-8 and Malignancies in
    Immunodeficient Patients 555
    Malignancies in Primary Immunodeficiencies 556
    Secondary Immunodeficiency and Cancer 559
    Malignancies in the Posttransplant Patient 560
    Summary 565
    21 Histiocytoses 568
    Kenneth L. McClain, Carl E. Allen, Johannes H. Visser,
    and M. John Hicks
    Langerhans Cell Histiocytosis 568
    Hemophagocytic Lymphohistiocytosis 573
    Sinus Histiocytosis with Massive Lymphadenopathy
    (Rosai–Dorfman Disease) 576
    Juvenile Xanthogranuloma 576
    Malignant Histiocytic Diseases 577
    Summary 578
    Management Summary 578
    22A Gliomas, Ependymomas, and Other
    Nonembryonal Tumors of the Central
    Nervous System 582
    D. Williams Parsons, Ian F. Pollack, Daphne A. Hass-Kogan,
    Arnold C. Paulino, Stephen F. Kralik, Nilesh K. Desai, Adekunle
    M. Adesina, and Murali M. Chintagumpala
    Epidemiology 582
    Inherited Syndromes Associated with Central Nervous
    System Tumors 582
    Ionizing Radiation and Central Nervous System
    Tumors 583
    Pathologic Classification of Central Nervous System
    Tumors 584
    Clinical Presentation 585
    Neuroimaging in Pediatric Central Nervous
    System Tumors: Current Status and Future
    Directions 587
    Neurosurgery: Diagnosis and Treatment 589
    Radiation Therapy 591
    Principles of Chemotherapy 593
    Ependymoma 593
    Low-Grade Gliomas 595
    Tumors of the Optic Pathway 599
    Supratentorial High-Grade Gliomas 600
    Brainstem Gliomas 602
    Craniopharyngioma 605
    Choroid Plexus Neoplasms 607
    Intramedullary Spinal Cord Tumors 608
    Sequelae of Treatment 609
    22B Tumors of the Central Nervous System:
    Embryonal and Pineal Region Tumors 614
    Annie Huang, Holly Lindsay, Benita Tamrazi,
    Adekunle M. Adesina, Arnold C. Paulino, Ian F. Pollack,
    Eric Bouffet, and Murali M. Chintagumpala
    Embryonal Tumors 614
    Medulloblastoma 614
    Atypical Teratoid/Rhabdoid Tumor 624
    Embryonal Tumors with Multilayered Rosettes 628
    Other Rare Embryonal Tumors 631
    Pineal Region Tumors 632
    Germ Cell Tumors 637
    23 Neuroblastoma 647
    Julie R. Park, Michael D. Hogarty, Rochelle Bagatell, Gudrun
    Schleiermacher, Yael P. Mossé, and John M. Maris
    Epidemiology 647
    Genetic Predisposition 647
    Molecular Pathogenesis 649
    Pathology 652
    Clinical Presentation 653
    Paraneoplastic Syndromes 653
    Clinical and Laboratory Evaluation 654
    Staging and Treatment Response 655
    Prognostic Considerations 657
    Principals of Initial Therapy 660
    Late Effects 665
    Future Considerations 666
    24 Renal Tumors 673
    Conrad V. Fernandez, James I. Geller, Peter F. Ehrlich, Marry M.
    van den Heuvel-Eibrink, Norbert Graf, Elizabeth A. Mullen, D.
    Ashley Hill, John A. Kalapurakal, and Jeffrey S. Dome
    Epidemiology 673
    Genetics and Molecular Biology 673
    Pathology 675
    Clinical Presentation and Diagnostic Workup 677
    Prognostic Factors 678
    Treatment of Wilms Tumor 680
    Clear Cell Sarcoma of the Kidney 687
    Malignant Rhabdoid Tumor 688
    Renal Cell Carcinoma 689
    Congenital Mesoblastic Nephroma 689
    25 Rhabdomyosarcoma 693
    Corinne M. Linardic and Leonard H. Wexler
    Epidemiology and Genetic Susceptibility 693
    Molecular Biology 694
    Animal Models 695
    Pathology 695
    Patterns of Spread and Clinical Presentation 698
    Methods of Diagnosis 701
    Staging 702
    Prognostic Considerations 703
    Treatment 705
    Perspectives 715
    26 Nonrhabdomyosarcoma Soft-Tissue
    Sarcomas 721
    Douglas S. Hawkins, Jennifer O. Black, Daniel Orbach, Thomas J.
    Scharschmidt, Monika Scheer, Stephanie A. Terezakis, Rajkumar
    Venkatramani, and Aaron R. Weiss
    Epidemiology 721
    Pathology 722
    Clinical Presentation 723Prognostic Factors 724
    Staging 724
    General Treatment Considerations 724
    Radiation Therapy 726
    Chemotherapy 727
    Selected Specific Diseases (Grouped First by Biologic
    Potential and then in Alphabetical Order) 730
    Intermediate, Locally Aggressive Soft-Tissue
    Tumors 730
    Intermediate, Rarely Metastasizing Soft-Tissue
    Tumors 734
    Future Directions 742
    27 Ewing Sarcoma 747
    Stephen L. Lessnick, Patrick J. Grohar, Steven G. DuBois,
    Pancras C.W. Hogendoorn, Darin Davidson, Nadia Nicole Laack,
    and Uta Dirksen
    Nomenclature 747
    Biology 747
    Clinical Presentation and Staging 751
    Pathology 753
    Initial Treatment 754
    Treatment 755
    Management of Recurrent Disease 763
    Late Effects 765
    Summary and Conclusions 765
    28 Osteosarcoma 770
    Katherine A. Janeway, R. Lor Randall, and Richard Gorlick
    Introduction 770
    Clinical Presentation 770
    Epidemiology 774
    Pathology 776
    Biology 778
    Treatment 781
    New Drugs 784
    Follow-Up and Late Effects 788
    29 Germ Cell Tumors 793
    A. Lindsay Frazier, Thomas A. Olson, Dominik T. Schneider,
    and James F. Amatruda
    Nomenclature 793
    Embryogenesis and Histogenesis of Gonadal
    Tumors 793
    Genetics and Molecular Biology 794
    Pathology 795
    Tumor Markers 798
    Clinical Presentation, Staging, and Risk Assignment 799
    Treatment Overview 802
    Surgical Approach: Ovarian Tumors 803
    Salvage Strategies 808
    Toxicity and Late Effects 808
    Future Considerations 809
    30 Endocrine Tumors 811
    Sogol Mostoufi-Moab, Rajkumar Venkatramani, Andrew J. Bauer,
    and Steven G. Waguespack
    Pituitary Tumors 811
    Parathyroid Tumors 817
    Thyroid Tumors 819
    Gastroenteropancreatic Neuroendocrine Tumors 827
    Adrenal Tumors 831
    Pheochromocytoma and Paraganglioma 834
    31 Liver Tumors 842
    Howard M. Katzenstein, Dolores H. López-Terrada, Greg Tiao,
    and Andras Heczey
    Approach to Children with a Liver Mass 842
    Hepatoblastoma 843
    Staging, Pretreatment Extent of Tumor (Pretext) and
    Current Risk Group Stratification of HB 849
    Surgery in HCC 857
    Hepatocellular Benign and Premalignant Epithelial
    Biliary Epithelial and Mixed Biliary-Hepatocellular
    Tumors 859
    Mixed Epithelial/Mesenchymal or Uncertain Origin 859
    Mesenchymal Tumors, Malignant 860
    Metastatic and Other Malignant Tumors Involving
    the Liver 863
    32 Retinoblastoma 868
    Ann-Marie Leahey, Dan S. Gombos, and Patricia Chevez-Barrios
    Epidemiology 868
    Anatomy 868
    Genetics 869
    Clinical Presentation 870
    Diagnosis 871
    Pathology 872
    Metastasis and Recurrence 876
    Trilateral Retinoblastoma and Other Tumors 877
    Staging 877
    Therapeutic Options 881
    Immediate Future Directions 886
    33 Rare Tumors 889
    Rajkumar Venkatramani, Samara L. Potter, Kris Ann P. Schultz,
    and Carlos Rodriguez-Galindo
    Head and Neck 889
    Chest 895
    Abdomen 897
    Genitourinary System/Pelvis 900
    Skin 901
    Bone Tumors 903
    Conclusion 904
    SECTION 5
    Supportive Care of Children
    with Cancer
    34 Oncologic Emergencies 909
    Susan R. Rheingold, Amanda M. Li, and Jason Lawrence
    Freedman
    Cardiothoracic Emergencies 909
    Gastrointestinal Emergencies 913
    Genitourinary Emergencies 917
    Metabolic and Endocrine Emergencies 918
    Neurologic Emergencies 923
    Therapy-Associated Emergencies 930
    Summary 933
    35 Hematologic Supportive Care 937
    Lani D. Lieberman, Amber M. Yates, and Jennifer Andrews
    Anemia 937
    Thrombocytopenia 939
    Other Transfusion Products 942
    Complications of Transfusion 944
    Hematopoietic Colony-Stimulating Factors 950
    36 Infectious Complications in Children with
    Underlying Malignancy 955
    Monica I. Ardura and Andrew Y. Koh
    Host Defenses: Innate and Adaptive Immunity 955
    Care of Febrile Cancer Patients 957
    Empirical Antibacterial Treatment of Febrile
    Neutropenic Patients 960
    Antifungal Agents 966
    Antiviral Agents 968
    Anti-Pneumocystis Pneumonia Agents 971
    Management of Unexplained Fever in the
    Neutropenic Patient 971
    Evaluation and Management of Documented
    Infections 972
    Prevention of Infection in Children with Cancer 988
    Prophylactic Antibiotics 989Granulocyte Transfusions 992
    Recombinant Human Cytokines 992
    Adoptive T-Cell Therapy 994
    Future Directions 994
    37 Nursing Support of the Child
    with Cancer 1002
    Marilyn J. Hockenberry
    Direct Patient Care Nursing Roles 1002
    Advanced Practice Roles 1002
    Research Roles 1003
    Nursing Standards of Care 1003
    Providing Expert Clinical Nursing Care 1003
    Professional Development 1012
    38 Nutritional Supportive Care 1014
    Deena Altschwager and Alexandra N. Carey
    Definition of Cancer Cachexia 1014
    Obesity and the Pediatric Patient with Cancer 1015
    The Population at Risk 1015
    Etiology and Pathophysiology 1016
    Clinical Assessment of Nutritional Status 1017
    Nutrition Intervention Techniques 1019
    Vitamins in Treating the Pediatric Patient with
    Cancer 1021
    Nutritional Concerns of Long-Term Survivors of
    Childhood Cancer 1022
    Conclusion 1022
    39 Rehabilitation of the Child with Cancer 1024
    Elaine Y. Tsao, David W. Pruitt, and Mary A. McMahon
    Rehabilitation Problems 1024
    Specific Childhood Cancers: Rehabilitation Issues 1029
    Spinal Cord Tumors 1031
    Bone Tumors 1033
    Acute Lymphoblastic Leukemia 1034
    40 Pain and Symptom Management 1038
    Elliot J. Krane, Lori S. Wiener, Roy L. Kao, and Lonnie K. Zeltzer
    Introduction 1038
    Pain 1038
    Etiologies of Cancer Pain 1045
    Multimodal Management of Pain 1049
    Pharmaceutical Management of Cancer-Related Pain
    in Children 1050
    Interventional Procedures for Pain Management 1057
    Somnolence, Fatigue, Insomnia 1058
    Summary 1062
    41 Psychosocial Support for the
    Child and Family 1067
    Lori S. Wiener, Marieke Van Schoors, Maryland Pao,
    and Melissa A. Alderfer
    Principles and Essential Knowledge for Health
    Professionals 1067
    The Initial Diagnostic Period: A Time of Crisis 1067
    Treatment: Reestablishing Equilibrium 1069
    Relapses: A Second Crisis 1073
    Survivorship 1076
    Family Considerations 1077
    Psychosocial and Psychiatric Interventions 1079
    Final Word 1080
    42 Educational Issues for Children with
    Cancer 1083
    Lisa M. Jacola, Lisa S. Kahalley, Stephanie K. Powell, Julie Baran,
    and Robert B. Noll
    School Reentry: Considerations and Stakeholders 1083
    Evidence Base and Standards of Care 1084
    Components of School Reentry Programs 1084
    Special Education Services in Childhood Cancer
    Survivors 1091
    43 Palliative Care for the Child
    with Cancer 1098
    Jennifer M. Snaman, Jessica A. Casas, Tammy I. Kang, and
    Joanne Wolfe
    The Interdisciplinary Nature of Palliative Care 1099
    Palliative Care for Children with Cancer 1099
    Other Considerations at the End of Life 1116
    SECTION 6
    Other Considerations in Childhood
    Cancer
    44 Adolescents and Young Adults with Cancer
    and Transitional Care to Adulthood 1123
    David R. Freyer, Barbara Jones, Jennifer M. Levine,
    Diana Jean Moke, and Michael Roth
    Cancer Incidence and Survival Trends 1123
    Treatment-Related Toxicity 1128
    Clinical Trial Enrollment 1129
    Psychosocial Issues 1130
    Cancer Survivorship 1131
    Conclusions 1132
    Management Summary 1133
    45 Late Effects of Childhood Cancer and its
    Treatment 1135
    Wendy Landier, Saro Armenian, M. Monica Gramatges,
    Eric J. Chow, and Smita Bhatia
    Burden of Morbidity 1137
    Standardized Recommendations for Follow-Up of
    Childhood Cancer 1138
    Auditory Complications 1138
    Neurocognitive Sequelae 1139
    Cardiovascular Function 1139
    Pulmonary Function 1140
    Genitourinary Abnormalities 1141
    Gastrointestinal Function 1142
    Gonadal Function 1142
    Other Endocrinologic Outcomes 1144
    Growth Hormone Deficiency 1144
    Obesity and Metabolic Syndrome 1144
    Musculoskeletal and Related Tissues 1145
    Subsequent Malignant Neoplasms 1146
    Late Mortality Among Childhood Cancer
    Survivors 1148
    New Agents and New Potential
    Late Effects 1148
    Cancer Survivorship—Future Research
    Opportunities 1149
    46 Cancer Clinical Trials: Design, Conduct,
    Analysis, and Reporting 1153
    Arzu Onar-Thomas, Patricia Baxter, Lisa Bomgaars,
    and Stacey L. Berg
    Planning a Clinical Trial 1153
    Feasibility Assessment 1159
    Protocol Writing 1159
    Regulatory Affairs 1160
    Conduct of the Clinical Trial 1160
    Analyzing Clinical Trial Data 1161
    Reporting Results of Clinical Trials 1163
    47 Ethical Considerations in Pediatric
    Oncology 1165
    Bryan Sisk, Avram E. Denburg, Abby R. Rosenberg, and
    Eric Kodish
    Informed Consent and Decision-Making 1165
    Ethics of Research Involving Children with
    Cancer 1167Privacy and Confidentiality 1175
    Genetics and Genomics 1176
    Population Inequities in Childhood Cancer Care and
    Outcomes 1177
    Caring for Health Care Providers 1179
    Conclusion 1180
    48 The Other Side of the Bed: What Providers
    Can Learn from Listening to Patients and
    Their Families 1185
    Donna Ludwinski, Vikas Kundra, Nancy Goodman, Leona Knox,
    and Elena Gerasimov
    General Issues of Communication and Trust 1185
    Major Events in the Care of Patients and
    Their Families 1189
    Conclusion 1196
    49 Complementary and Integrative Therapies in
    Pediatric Oncology 1197
    Thomas Williams McLean and Susan F. Sencer
    History 1197
    Definitions 1197
    Epidemiology 1197
    Patients’ and Families’ Reasons for Using Complementary
    and Integrative Therapies 1198
    Talking with Patients and Families 1198
    Integrative Therapy Modalities 1200
    Biochemical Therapies 1200
    Toxicities and Other Risks 1201
    Lifestyle Therapy: Diet, Exercise, Environment, and
    Mind–Body 1201
    Environment 1202
    Mind–Body 1202
    Biomechanical Therapies 1202
    Bioenergetic Therapies 1203
    Summary 1204
    50 Economic Issues in Pediatric Cancer 1207
    Susan K. Parsons, Pei-Jung Lin, and K. Robin Yabroff
    Patient–Physician Communication about Cost of
    Cancer Care 1208
    Methods of Economic Evaluation 1209
    Financing Care 1212
    Family Impact 1213
    Conclusion 1215
    51 Pediatric Cancer: Advocacy and Policy Issues
    for Patients, Families, and Survivors 1218
    Susan L. Weiner and Victoria Buenger
    Landscape of the Childhood Cancer Advocacy
    Community 1218
    Advocates’ Central Policy Priorities 1219
    Ongoing and Emerging Issues for Advocates 1224
    52 Maximizing Safety in Cancer Treatment 1227
    Brigitta U. Mueller and Amy L. Billett
    Background 1227
    Recognizing and Reporting of Problems 1229
    Event Reporting 1230
    Preventing Errors 1231
    53 Pediatric Oncology in Low- and Middle-
    Income Countries 1236
    Joseph Lubega, Lulu F. Chirande, Kathy Pritchard-Jones,
    and David G. Poplack
    Epidemiology and Burden of Pediatric Cancer in
    LMICs 1236
    Health Systems and Sociocultural Barriers to Pediatric
    Cancer Care in LMICs 1238
    Shortage of Multispecialty Expertise for Pediatric Cancer
    Care 1239
    Diagnosis and Risk-Stratification Modalities of Pediatric
    Cancer in LMICs 1239
    Access to Cancer Treatment Modalities: Drugs, Pediatric
    Surgery, and Radiotherapy 1240
    Supportive Care for Children on Cancer Treatment in
    LMICs 1240
    Palliative Care for Children with Cancer in LMICs 1242
    Survivorship Care for Children with Cancer in
    LMICs 1242
    Pediatric Oncology Research in LMICs 1242
    Index 1245
  • Features
    • Covers all aspects of the breadth and depth of childhood cancer, including basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy.
    • Includes updates to current treatment approaches based on the results of recently completed and published clinical research.
    • Contains new information on the biology of pediatric malignancies and strategies for the conduct of clinical trials that reflect the rapid pace of laboratory discovery.
    • Features chapters on palliative care and education, and covers supportive care in contexts such as emergencies, infectious disease, and nutrition.
    • Provides expert guidance on state-of-the-art, multidisciplinary care for children and families, including psychosocial aspects of care and perspectives from patients and parents.
    • Discusses the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia. 
    Enrich Your eBook Reading Experience
    • Read directly on your preferred device(s), such as computer, tablet, or smartphone.
    • Easily convert to audiobook, powering your content with natural language text-to-speech.
  • Review
  • Questions and Answers

Sorry, we can’t add this product to your cart due to one of the following reasons:

  • This item may already be in your cart.
  • This item can’t be combined with other items in your cart.
  • Only one instance of this product can be purchased at a time.

Would you like us to update your cart with this item and proceed?

9781975124793 Pizzo & Poplack's Pediatric Oncology 9781975124793 Home / Medicine / Pizzo & Poplack's Pediatric Oncology 1 https://shop.lww.com/Pizzo---Poplack-s-Pediatric-Oncology/p/9781975124793 //cdn-tp2.mozu.com/16833-25855/cms/25855/files/614a5e81-b003-4344-9fef-bf6d7fb840db 399.99 399.99 399.99 1

Your cart cannot contain products from multiple regions.
If you click continue, items in the cart from the previous region will be removed. To keep items from the previous region in your cart, click cancel.

This item is not related to current region.

Sorry, we can’t add this product to your cart due to one of the following reasons:

  • This item may already be in your cart.
  • This item can’t be combined with other items in your cart.
  • Only one instance of this product can be purchased at a time.

Would you like us to update your cart with this item and proceed?