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Hemostasis and Thrombosis

Basic Principles and Clinical Practice
9781608319060
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9781608319060
Publication Date
November 26, 2012
2012-11-26
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9781608319060
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  • Description
    Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.

    Hemostasis and Thrombosis, Sixth Edition

     

     Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.  

     

    NEW to the Sixth Edition…

    • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.

    • Full color throughout

    • A companion website that offers full text online and an image bank.

    • A new introductory section of chapters on basic sciences as related to the field

    • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.

    • Overview chapters preceding each section address broad topics of general importance.

  • Specs
    Edition
    6
    ISBN/ISSN
    9781608319060
    Product Format
    HC-Printed Cover
    Trim Size
    10.875 x 8.375
    Pages
    1592
    Illustration
    777
    Table
    550
    Publication Date
    November 26, 2012
    Weight
    8.85
  • About The Author(s)
    Victor J. Marder MD
    Professor of Clinical Medicine, Director, Vascular Medicine Program, Los Angeles Orthopaedic Hospital/UCLA; Division of Hematology/Medical Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
    William C. Aird MD
    Associate Professor of Medicine, Beth Israel Deaconness Medical Center, Boston, MA
    Joel S. Bennett MD
    Professor of Medicine, University of Pennsylvania, Philadelphia, PA
    Sam Schulman MD
    Professor of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gilbert C. White II MD
    Executive Vice President for Research, Blood Center of Wisconsin, Milwaukee, WI 
  • Features

    NEW to the Sixth Edition…

    • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.

    • Full color throughout

    • A companion website that offers full text online and an image bank.

    • A new introductory section of chapters on basic sciences as related to the field

    • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.

    • Overview chapters preceding each section address broad topics of general importance.

  • Table of contents
    HEMOSTASIS AND THROMBOSIS:

    BASIC PRINCIPLES AND CLINICAL PRACTICE

    SIXTH EDITION

     

     

    Part 1: Introduction to the Field of Hemostasis and Thrombosis

     

     

    Chapter 1.  History of the Field

    William C. Aird and Gilbert C. White, II

     

    Chapter 2.  Molecular Evolution of the Vertebrate Blood Coagulation System

    Marianne A. Grant and William C. Aird

     

    Chapter 3.  Molecular and Clinical Genetics

    Lesley Everett, Karl C. Desch, and David Ginsburg

     

    Chapter 4:  Coagulation Enzymology

    Sriram Krishnaswamy

     

    Chapter 5: Cell Biology, Protein Processing, and Cell Signaling

    Randal J. Kaufman and Laura Popolo

     

    Chapter 6: Cellular and Molecular Immunology

    Andrew H. Lichtman

     

    Chapter 7:  Biostatistics and Epidemiology: The Basic Science of Clinical Research

    Kerry L. Lee

     

    PART II: BASIC HEMOSTASIS AND THROMBOSIS

    SECTION A: COAGULATION & FIBRINOLYSIS

     

    Chapter 8: Overview of Basic Coagulation and Fibrinolysis

    Gilbert C. White, II, Victor J. Marder, Sam Schulman, William C. Aird, and Joel S. Bennett

     

    Chapter 9:  The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression

    Dominic W. Chung, Wengfeng Xu, and Earl W. Davie

     

    Chapter 10: Genetics of Coagulation Proteins

    Rodney M. Camire and Paris Margaritis

     

    Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation

    George J. Broze, Jr. and James H. Morrissey

     

    Chapter 12: Factors V and VIII

    Randal J. Kaufman, Philip J. Fay, Laura Popolo, and Thomas L. Ortel

     

    Chapter 13: Structure and Function of von Willebrand Factor

    Sandra L. Haberichter and Robert R. Montgomery

     

    Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins

    Kanagasabai Vadivel, Amy E. Schmidt, Victor J. Marder, Sriram Krishnaswamy, and S. Paul Bajaj

     

    Chapter 15A:  Factor XI

    Peter N. Walsh and David Gailani

     

    Chapter 15B: The Factor XII-driven Plasma Contact System

    Thomas Renne

     

    Chapter 16:  Fibrinogen Structure and Function

    John W. Weisel and Carl-Erik Dempfle

    Chapter 17: Factor XIII

    Cédric Duval, Helen Philippou, and Robert A. S. Ariëns

     

    Chapter 18: Antithrombin and the Serpin Family

    Susan C. Bock

     

    Chapter 19:  Protein C and S and Thrombomodulin System

    Laurent O. Mosnier and John H. Griffin

    Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis

    Nuala A. Booth and Nicola J. Mutch

     

    Chapter 21:  Inhibitors of Fibrinolysis

    Björn Wiman and Anna Ågren

     

    SECTION B: PLATELET BIOLOGY

     

    Chapter 22: Overview of Platelet Structure and Function

    Joel S. Bennett and Gilbert C. White, II

     

    Chapter 23:  Platelet Production: Cellular and Molecular Regulation

    Elisabeth Cramer Bordé and William Vainchenker

     

    Chapter 24: Megakaryocyte Structure and Platelet Biogenesis

    Joseph E. Italiano, Jr. and John H. Hartwig

     

    Chapter 25:  Thrombopoietin

    Kenneth Kaushansky and Ian Hitchcock 

     

    Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V

    Michael C. Berndt, and Robert K. Andrews

     

    Chapter 26B: Major Platelet Glycoproteins: GPIIb/IIIa

    Feng Ye and Mark H. Ginsberg

     

    Chapter 27:  Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity

    Thomas J. Kunicki and Diane J. Nugent

     

    Chapter 28: The Basis for Platelet Adhesion

    Brian Savage and Zaverio M. Ruggeri

     

    Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis

    David L. Bark Jr., Warwick S. Nesbitt, Angus K.T. Wong, and Shaun P. Jackson

     

    Chapter 30: Platelets and Collagen

    Steve P Watson, Richard W Farndale, Masaaki Moroi, and Stephanie M Jung

     

    Chapter 31: Integrin αIIb β3 and Platelet Aggregation

    Ana Kasirer-Friede, Kamila Bledzka, Jun Qin, , Edward F. Plow, and Sanford J. Shattil

     

    Chapter 32:  Molecular Basis for Platelet Secretion

    Shaojing Ye and Sidney W. Whitehart

     

    Chapter 33: Platelet Signal Transduction

    Charles S. Abrams and Lawrence F. Brass 

     

    Chapter 34:  Platelet Prostaglandin Metabolism

    Tilo Grosser and Garret A. FitzGerald

     

    Chapter 35:  The Role of Platelets in Blood Coagulation

    Peter N. Walsh

     

    Chapter 36:  Blood-Borne Microparticles

    José López and Swaminathan Murugappan

     

    SECTION C: VASCULAR BIOLOGY  

    William C. Aird

     

    Chapter 37:  Overview of Vascular Biology

    William C. Aird

     

    Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis

    Aernout Luttun and Peter Carmeliet

     

    Chapter 39: Rheology and Vessel Wall Stress

    Peter F. Davies, Larry V. McIntire, and Juan M. Jiménez

     

    Chapter 40:  Nitric Oxide

    Bradley A. Maron and Thomas Michel

    Chapter 41:  Blood Vessel Wall in Health and Disease

    Keith R. Brunt, Sonya Hui, Jagdish Butany, and Mansoor Husain

     

    Chapter 42:  Endothelial Cell Function

    William C. Aird

     

    Chapter 43:  Role of Endothelium in Hemostasis

    Michael J. Krisinger and Edward M. Conway

     

    Chapter 44:  Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway

    Wolfram Ruf

     

    Chapter 45:  Heparin and Vascular Proteoglycans

    Douglas M. Tollefsen and Lijuan Zhang

     

    Chapter 46: Endothelial Cell-Blood Cell Interactions

    Klaus Ley

     

    Chapter 47:  Leukocyte Function and Contribution to Disease

    Edith van de Vijver and Taco W. Kuijpers

     

    Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction

    Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel

     

    PART III:  DISORDERS OF COAGULATION, PLATELETS, AND VESSEL WALL

    SECTION A: BLEEDING DISORDERS COAGULATION & FIBRINOLYSIS

     

    Chapter 49: Overview of Inherited Hemorrhagic Disorders

    Gilbert C. White, II, Harold R. Roberts, and Victor J. Marder

     

    Chapter 50:  Differential Diagnosis of the Bleeding Patient

    Jill M. Johnsen and Barbara A. Konkle 

     

    Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia

    Edward G.D. Tuddenham

     

    Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment

    J. Evan Sadler and David Lillicrap

     

    Chapter 53:  Rare Inherited Coagulation Disorders Other than Hemophilia

    Pier Mannuccio Manucci, Massimo Franchini, and Flora Peyvandi

     

    Chapter 54: Afibrogenemias and Dysfibrogenemias

    Dennis K. Galanakis

     

    Chapter 55: Familial Multiple Coagulation Factor Deficiencies

    Bin Zhang and David Ginsburg

     

    Chapter 56:  Clinical Disorders of Fibrinolysis

    Daphne Stewart, Charles W. Francis, and Victor J. Marder

     

    Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies

    Charles RM Hay

     

    Chapter 58:  Laboratory Markers of Coagulation and Fibrinolysis

    Kenneth A. Bauer and Helen A. Ireland

     

    SECTION B: ACQUIRED & INHERITED PLATELET DISORDERS

     

    Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders

    Joel S. Bennett

     

    Chapter 60: Differential Diagnosis of Thrombocytopenia

    Joel S. Bennett and Charles S. Abrams

     

    Chapter 61:  Immune Thrombocytopenic Purpuraand Posttransfusion Purpura

    Howard A. Liebman, Douglas B. Cines, and James B. Bussel

     

    Chapter 62: Drug-Induced Thrombocytopenia

    Richard H. Aster and James N. George

     

    Chapter 63: Inherited Thrombocytopenias

    Paquita Nurden and Alan T. Nurden

     

    Chapter 64: Acquired Nonimmune Thrombocytopenia

    Andreas Greinacher and Theodore E. Warkentin

     

    Chapter 65:  Hereditary Disorders of Platelet Function

    Joel S. Bennett and A. Koneti Rao

     

    Chapter 66: Acquired Disorders of Platelet Function

    A. Koneti Rao and Joel S. Bennett

     

    Chapter 67: Laboratory Markers of Platelet Activation

    Paul Harrison and Alan D. Michelson

     

    SECTION C: PRIMARY DISORDERS OF BLOOD VESSELS 

     

    Chapter 68: Overview of Primary Disorders of Blood Vessels

    William C. Aird

     

    Chapter 69: Disorders of Connective Tissue and Extracellulara Matrix

    Fransiska Malfait and Anne dePaepeChapter 70: Hereditary Hemorrhagic Telangiectasia

    Michelle Letarte and Claire L. Shovlin

     

    Chapter 71: Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations

    Douglas A. Marchuk and Mark L. Kahn

     

    Chapter 72: Aneurysms (Large and Small Arteries)

    Carlos E. Sanchez, Sangita Kapur, and Neal L. Weintraub

     

    Chapter 73: Intracranial Hemorrhage

    Timolaos Rizos and Thorsten Steiner 

     

    Chapter 74: Retinopathy

    Jing Chen, , Andreas Stahl, and Lois E.H. Smith

     

    SECTION D: THERAPY OF BLEEDING DISORDERS

     

    Chapter 75: Overview to Therapy of Bleeding Disorders

    Gilbert C. White II

     

    Chapter 76: Management of Acute Hemorrhage

    Nigel S. Key, Micah J. Mooberry, and Rommer Lu

     

    Chapter 77: Therapy with Antifibrinolytic Agents

    Daphne B. Stewart and Victor J. Marder

     

    Chapter 78: Transfusion Medicine

    Thomas S. Kickler

     

    Chapter 79: New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy

    Gilbert C. White II and Harold R. Roberts

     

    PART IV: THROMBOTIC DISORDERS

     

    SECTION A: VENOUS THROMBOTIC DISORDERS

     

    Chapter 80.  Overview of Venous Thromboembolism

    Sam Schulman, Victor J. Marder, and Gilbert C. White II

     

    Chapter 81: Thrombophilia Genetics

    Joseph Emmerich, Martine Aiach, and Pierre-Emmanuel Morange

     

    Chapter 82: Epidemiology and Risk Factors of Venous Thromboembolism

    John A. Heit

     

    Chapter 83: Clinical Manifestations and Diagnosis of Venous Thromboembolism

    Henri Bounameaux and Arnaud Perrier

     

    Chapter 84: Venous Thrombosis in Unusual Sites

    Victor J. Marder, Hylton V. Joffe, and Sam Schulman

     

    Chapter 85: Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension

    Vittorio Pengo and Susan R. Kahn

     

    Chapter 86: Prevention of Venous Thromboembolic Disease

    Menno V. Huisman, Ajay Kakkar, Pasha, and Patrick Mismetti

     

    Chapter 87: Treatment of Venous Thromboembolic Disease

    Sam Schulman, Jeffrey Ginsberg, and James Douketis

     

    SECTION B: ARTERIAL THROMBOTIC DISORDERS

     

    Chapter 88: Overview of Arterial Thrombotic Disorders

    Sam Schulman and Victor J. Marder

     

    Chapter 89: Pathophysiology of Atherosclerosis

    Peter Libby, Paul M. Ridker, and Kevin Croce

     

    Chapter 90: Acute Coronary Syndromes: Manifestations and Management

    John Paul Vavalle, John H. Alexander, and Matthew T. Roe

     

    Chapter 91: Pathophysiology of Thromboembolic Stroke

    Emer R. McGrath and Martin J. O'Donnell

     

    Chapter 92: Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, Cardiomyopathy

    Thomas Kawano and Jonathan L. Halperin

     

    Chapter 93: Acute Stroke: General Management, Anticoagulant, and Thrombolytic Therapy

    Gregory J. del Zoppo and Jeffrey L. Saver  

     

    Chapter 94: Medical and Surgical Treatment of Peripheral Arterial Disease

    Phillip Joseph, Saurabh Kalra, and Sonia Anand

     

    Chapter 95: Unusual Sites of Arterial Occlusion

    Philip A. Kalra, Jon G. Moss, and Peter Wiedemann

     

    Chapter 96: Pathogenesis and Treatment of Biomaterial-Associated Thrombosis

    Maud B. Gorbet and Michael V. Sefton

     

    SECTION C:  COMPLEX THROMBOTIC DISORDERS

     

    Chapter 97: Overview of Microvascular and Complex Thrombotic Disorders

    Theodore E. Warkentine and Victor J. Marder

     

    Chapter 98: Consumptive Thrombohemorrhagic Disorders

    Marcel Levi, Donald I. Feinstein, Robert W. Colman, and Victor J. Marder

     

    Chapter 99: Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome-Microangiopathies

    George

     

    Chapter 100: Vasculitides

    James R. Stone and John H. Stone

     

    Chapter 101: Antiphospholipid Antibodies and the Antiphospholipid Syndrome

    Jacob H. Rand and Lucia R. Wolgast

     

    Chapter 102: Thrombohemorrhagic Complications of Myeloproliferative Disorders

    Ayalew Tefferi

     

    Chapter 103:  Thrombotic and Hemorrhagic Complications Associted with Stem Cell Transplantation

    Yona Nadir and Benjamin Brenner

     

    SECTION D: THERAPEUTIC AGENTS

     

    Chapter 104: Overview of Therapeutic Agents used in Thrombotic Disorders

    Sam Schulman and Victor J. Marder

     

    Chapter 105: Pharmacology and Mode of Action of Heparin and Glycosaminoglycans

    Meyer Michael Samama, Jeanine M. Walenga, Evi Kalodiki, and Jawed Fareed

     

    Chapter 106: Vitamin K Antagonists: Biochemistry, Pharmacology and Management

    Nirmish Shah, Thomas L. Ortel, and Sam Schulman

     

    Chapter 107: Hemorrhagic Complications of Anticoagulation

    Sam Schulman and Mark A. Crowther

     

    Chapter 108: Heparin-Induced Thrombocytopenia

    Theodore E. Warkentin and Andreas Greinacher

     

    Chapter 109: Coumarin-Induced Skin Necrosis and Venous Limb Gangrene

    Theodore E. Warkentin

     

    Chapter 110: New Antithrombotic Drugs

    Jeffrey I. Weitz and Peter L. Gross

     

    Chapter 111: Antiplatelet Therapy

    Carlo Patrono

     

    Chapter 112: Thrombolytic Therapy

    Victor J. Marder and Daphne B. Stewart

     

    Chapter 113: Anticoagulant and Procoagulant Proteinsin the Animal Kingdom

    Angelina Wei Ling Tan, Shiyang Kwong, and R. Manjunatha Kinia

     

    Chapter 114: Mechanical Devices and Embolectomy

    Hervé Decousus, Patrick Mismetti, and Nicolas Meneveau

     

    PART V:Hemostatic and Thrombotic Disorders Associated with Systemic Conditions

     

    Chapter 115: Overview of Special Clinical Groups

    Victor J. Marder

     

    Chapter 116: VTE during Pregnancy and with Hormonal Contraceptives

    Saskia Middeldorp, Mathilde Nijkeuter, and Michiel Coppens

     

    Chapter 117: Gestational Vascular Complications

    Benjamin Brenner, Anat Aharon, Jean-Christophe Gris

     

    Chapter 118: Maternal Hemostatic Disorders and Obstetric Hemorrhage

    Philippe De Moerloose, Françoise Boehlen, and Jean Christophe Gris

     

    Chapter 119: Developmental Hemostasis

    Paul Monagle, Vera Ignatovic, and Leslie Roy Berry

     

    Chapter 120: Bleeding in Neonates and Children

    Anthony K. Chan, Elizabeth A. Chalmers, Sam Schulman, and Alan Michelson

     

    Chapter 121: Venous and Arterial Thromboembolism in Children

    Paul Monagle, M. Patricia Massicotte, and Anthony K. Chan

     

    Chapter 122: Thrombotic Complications of Sickle Cell Disease

    Kenneth I. Ataga and Elliott P. Vichinsky

     

    Chapter 123: Thrombohemorrhagic Complications of Sepsis

    Marcel Levi

     

    Chapter 124: Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features

    Gayani Tillekeratne, Jennifer Cohn, and Hillary Dunlevy

     

    Chapter 125: Cancer-related Thrombosis

    Anna Falanga, Agnes Y. Y. Lee, Frederick R. Rickles

     

    Chapter 126: Hemostatic Abnormalities in Liver Disease

    Charles S. Eby and Stephen H. Caldwell

     

    Chapter 127: Hemostatic Abnormalities in Renal Disease

    Miriam Galbusera, Giuseppe Remuzzi, and Patrizia Ondei

     

    Chapter 128: Multtrauma Derangements in Hemostasis and Thrombosis

    Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, and Mitchell Jay Cohen

     

    Chapter 129: Blood Management in the Cardiovascular Surgery Patient

    Lawrence Tim Goodnough and L. Henry Edmunds Jr.

     

    Chapter 130: Thrombo-Hemorrhagic Events in the Elderly

    Isabelle Mahe and Ludovic Drouet

     

     

     

     

     

     

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