Hemostasis and Thrombosis

HEMOSTASIS AND THROMBOSIS:
BASIC PRINCIPLES AND CLINICAL PRACTICE
SIXTH EDITION

Part 1: Introduction to the Field of Hemostasis and Thrombosis

Chapter 1. History of the Field
William C. Aird and Gilbert C. White, II

Chapter 2. Molecular Evolution of the Vertebrate Blood Coagulation System
Marianne A. Grant and William C. Aird

Chapter 3. Molecular and Clinical Genetics
Lesley Everett, Karl C. Desch, and David Ginsburg

Chapter 4: Coagulation Enzymology
Sriram Krishnaswamy

Chapter 5: Cell Biology, Protein Processing, and Cell Signaling
Randal J. Kaufman and Laura Popolo

Chapter 6: Cellular and Molecular Immunology
Andrew H. Lichtman

Chapter 7: Biostatistics and Epidemiology: The Basic Science of Clinical Research
Kerry L. Lee

PART II: BASIC HEMOSTASIS AND THROMBOSIS
SECTION A: COAGULATION & FIBRINOLYSIS

Chapter 8: Overview of Basic Coagulation and Fibrinolysis
Gilbert C. White, II, Victor J. Marder, Sam Schulman, William C. Aird, and Joel S. Bennett

Chapter 9: The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression
Dominic W. Chung, Wengfeng Xu, and Earl W. Davie

Chapter 10: Genetics of Coagulation Proteins
Rodney M. Camire and Paris Margaritis

Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation
George J. Broze, Jr. and James H. Morrissey

Chapter 12: Factors V and VIII
Randal J. Kaufman, Philip J. Fay, Laura Popolo, and Thomas L. Ortel

Chapter 13: Structure and Function of von Willebrand Factor
Sandra L. Haberichter and Robert R. Montgomery

Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins
Kanagasabai Vadivel, Amy E. Schmidt, Victor J. Marder, Sriram Krishnaswamy, and S. Paul Bajaj

Chapter 15A: Factor XI
Peter N. Walsh and David Gailani

Chapter 15B:The Factor XII-driven Plasma Contact System
Thomas Renne

Chapter 16: Fibrinogen Structure and Function
John W. Weisel and Carl-Erik Dempfle
Chapter 17: Factor XIII
Cédric Duval, Helen Philippou, and Robert A. S. Ariëns

Chapter 18: Antithrombin and the Serpin Family
Susan C. Bock

Chapter 19: Protein C and S and Thrombomodulin System
Laurent O. Mosnier and John H. Griffin
Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis
Nuala A. Booth and Nicola J. Mutch

Chapter 21: Inhibitors of Fibrinolysis
Björn Wiman and Anna Ågren

SECTION B: PLATELET BIOLOGY

Chapter 22: Overview of Platelet Structure and Function
Joel S. Bennett and Gilbert C. White, II

Chapter 23: Platelet Production: Cellular and Molecular Regulation
Elisabeth Cramer Bordé and William Vainchenker

Chapter 24: Megakaryocyte Structure and Platelet Biogenesis
Joseph E. Italiano, Jr. and John H. Hartwig

Chapter 25: Thrombopoietin
Kenneth Kaushansky and Ian Hitchcock

Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V
Michael C. Berndt, and Robert K. Andrews

Chapter 26B: Major Platelet Glycoproteins: GPIIB/IIIa
Feng Ye and Mark H. Ginsberg

Chapter 27: Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity
Thomas J. Kunicki and Diane J. Nugent

Chapter 28: The Basis for Platelet Adhesion
Brian Savage and Zaverio M. Ruggeri

Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis
David L. Bark Jr., Warwick S. Nesbitt, Angus K.T. Wong, and Shaun P. Jackson

Chapter 30: Platelets and Collagen
Steve P Watson, Richard W Farndale, Masaaki Moroi, and Stephanie M Jung

Chapter 31: Integrin αIIb β3 and Platelet Aggregation
Ana Kasirer-Friede, Kamila Bledzka, Jun Qin, , Edward F. Plow, and Sanford J. Shattil

Chapter 32: Molecular Basis for Platelet Secretion
Shaojing Ye and Sidney W. Whitehart

Chapter 33: Platelet Signal Transduction
Charles S. Abrams and Lawrence F. Brass

Chapter 34: Platelet Prostaglandin Metabolism
Tilo Grosser and Garret A. FitzGerald

Chapter 35: The Role of Platelets in Blood Coagulation
Peter N. Walsh

Chapter 36: Blood-Borne Microparticles
José López and Swaminathan Murugappan

SECTION C: VASCULAR BIOLOGY
William C. Aird

Chapter 37: Overview of Vascular Biology
William C. Aird

Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis
Aernout Luttun and Peter Carmeliet

Chapter 39: Rheology and Vessel Wall Stress
Peter F. Davies, Larry V. McIntire, and Juan M. Jiménez

Chapter 40: Nitric Oxide
Bradley A. Maron and Thomas Michel
Chapter 41: Blood Vessel Wall in Health and Disease
Keith R. Brunt, Sonya Hui, Jagdish Butany, and Mansoor Husain

Chapter 42: Endothelial Cell Function
William C. Aird

Chapter 43: Role of Endothelium in Hemostasis
Michael J. Krisinger and Edward M. Conway

Chapter 44: Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway
Wolfram Ruf

Chapter 45: Heparin and Vascular Proteoglycans
Douglas M. Tollefsen and Lijuan Zhang

Chapter 46: Endothelial Cell-Blood Cell Interactions
Klaus Ley

Chapter 47: Leukocyte Function and Contribution to Disease
Edith van de Vijver and Taco W. Kuijpers

Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction
Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel

PART III: DISORDERS OF COAGULATION, PLATELETS, AND VESSEL WALL
SECTION A: BLEEDING DISORDERS COAGULATION & FIBRINOLYSIS

Chapter 49: Overview of Inherited Hemorrhagic Disorders
Gilbert C. White, II, Harold R. Roberts, and Victor J. Marder

Chapter 50: Differential Diagnosis of the Bleeding Patient
Jill M. Johnsen and Barbara A. Konkle

Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia
Edward G.D. Tuddenham

Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment
J. Evan Sadler and David Lillicrap

Chapter 53: Rare Inherited Coagulation Disorders Other than Hemophilia
Pier Mannuccio Manucci, Massimo Franchini, and Flora Peyvandi

Chapter 54: Afibrogenemias and Dysfibrogenemias
Dennis K. Galanakis

Chapter 55: Familial Multiple Coagulation Factor Deficiencies
Bin Zhang and David Ginsburg

Chapter 56: Clinical Disorders of Fibrinolysis
Daphne Stewart, Charles W. Francis, and Victor J. Marder

Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies
Charles RM Hay

Chapter 58: Laboratory Markers of Coagulation and Fibrinolysis
Kenneth A. Bauer and Helen A. Ireland

SECTION B: ACQUIRED & INHERITED PLATELET DISORDERS

Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders
Joel S. Bennett

Chapter 60: Differential Diagnosis of Thrombocytopenia
Joel S. Bennett andCharles S. Abrams

Chapter 61: Immune Thrombocytopenic Purpuraand Posttransfusion Purpura
Howard A. Liebman, Douglas B. Cines, and James B. Bussel

Chapter 62: Drug-Induced Thrombocytopenia
Richard H. Aster and James N. George

Chapter 63: Inherited Thrombocytopenias
Paquita Nurden and Alan T. Nurden

Chapter 64: Acquired Nonimmune Thrombocytopenia
Andreas Greinacher and Theodore E. Warkentin

Chapter 65: Hereditary Disorders of Platelet Function
Joel S. Bennett and A. Koneti Rao

Chapter 66: Acquired Disorders of Platelet Function
A. Koneti Rao and Joel S. Bennett

Chapter 67: Laboratory Markers of Platelet Activation
Paul Harrison and Alan D. Michelson

SECTION C: PRIMARY DISORDERS OF BLOOD VESSELS

Chapter 68: Overview of Primary Disorders of Blood Vessels
William C. Aird

Chapter 69: Disorders of Connective Tissue and Extracellulara Matrix
Fransiska Malfait and Anne dePaepe Chapter 70: Hereditary Hemorrhagic Telangiectasia
Michelle Letarte and Claire L. Shovlin

Chapter 71: Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations
Douglas A. Marchuk and Mark L. Kahn

Chapter 72: Aneurysms (Large and Small Arteries)
Carlos E. Sanchez, Sangita Kapur, and Neal L. Weintraub

Chapter 73: Intracranial Hemorrhage
Timolaos Rizos and Thorsten Steiner

Chapter 74: Retinopathy
Jing Chen, , Andreas Stahl, and Lois E.H. Smith

SECTION D: THERAPY OF BLEEDING DISORDERS

Chapter 75: Overview to Therapy of Bleeding Disorders
Gilbert C. White II

Chapter 76: Management of Acute Hemorrhage
Nigel S. Key, Micah J. Mooberry, and Rommer Lu

Chapter 77: Therapy with Antifibrinolytic Agents
Daphne B. Stewart and Victor J. Marder

Chapter 78: Transfusion Medicine
Thomas S. Kickler

Chapter 79: New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy
Gilbert C. White II and Harold R. Roberts

PART IV: THROMBOTIC DISORDERS

SECTION A: VENOUS THROMBOTIC DISORDERS

Chapter 80. Overview of Venous Thromboembolism
Sam Schulman, Victor J. Marder, and Gilbert C. White II

Chapter 81: Thrombophilia Genetics
Joseph Emmerich, Martine Aiach, and Pierre-Emmanuel Morange

Chapter 82: Epidemiology and Risk Factors of Venous Thromboembolism
John A. Heit

Chapter 83: Clinical Manifestations and Diagnosis of Venous Thromboembolism
Henri Bounameaux and Arnaud Perrier

Chapter 84: Venous Thrombosis in Unusual Sites
Victor J. Marder, Hylton V. Joffe, and Sam Schulman

Chapter 85: Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension
Vittorio Pengo and Susan R. Kahn

Chapter 86: Prevention of Venous Thromboembolic Disease
Menno V. Huisman, Ajay Kakkar, Pasha, and Patrick Mismetti

Chapter 87: Treatment of Venous Thromboembolic Disease
Sam Schulman, Jeffrey Ginsberg, and James Douketis

SECTION B: ARTERIAL THROMBOTIC DISORDERS

Chapter 88: Overview of Arterial Thrombotic Disorders
Sam Schulman and Victor J. Marder

Chapter 89: Pathophysiology of Atherosclerosis
Peter Libby, Paul M. Ridker, and Kevin Croce

Chapter 90: Acute Coronary Syndromes: Manifestations and Management
John Paul Vavalle, John H. Alexander, and Matthew T. Roe

Chapter 91: Pathophysiology of Thromboembolic Stroke
Emer R. McGrath and Martin J. O'Donnell

Chapter 92: Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, Cardiomyopathy
Thomas Kawano and Jonathan L. Halperin

Chapter 93: Acute Stroke: General Management, Anticoagulant, and Thrombolytic Therapy
Gregory J. del Zoppo and Jeffrey L. Saver

Chapter 94: Medical and Surgical Treatment of Peripheral Arterial Disease
Phillip Joseph, Saurabh Kalra, and Sonia Anand

Chapter 95: Unusual Sites of Arterial Occlusion
Philip A. Kalra,Jon G. Moss,and Peter Wiedemann

Chapter 96: Pathogenesis and Treatment of Biomaterial-Associated Thrombosis
Maud B. Gorbet and Michael V. Sefton

SECTION C: COMPLEX THROMBOTIC DISORDERS

Chapter 97: Overview of Microvascular and Complex Thrombotic Disorders
Theodore E. Warkentine and Victor J. Marder

Chapter 98: Consumptive Thrombohemorrhagic Disorders
Marcel Levi, Donald I. Feinstein, Robert W. Colman, and Victor J. Marder

Chapter 99: Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome-Microangiopathies
George

Chapter 100: Vasculitides
James R. Stone and John H. Stone

Chapter 101: Antiphospholipid Antibodies and the Antiphospholipid Syndrome
Jacob H. Rand and Lucia R. Wolgast

Chapter 102: Thrombohemorrhagic Complications of Myeloproliferative Disorders
Ayalew Tefferi

Chapter 103: Thrombotic and Hemorrhagic Complications Associted with Stem Cell Transplantation
Yona Nadir and Benjamin Brenner

SECTION D: THERAPEUTIC AGENTS

Chapter 104: Overview of Therapeutic Agents used in Thrombotic Disorders
Sam Schulman and Victor J. Marder

Chapter 105: Pharmacology and Mode of Action of Heparin and Glycosaminoglycans
Meyer Michael Samama, Jeanine M. Walenga, Evi Kalodiki, and Jawed Fareed

Chapter 106: Vitamin K Antagonists: Biochemistry, Pharmacology and Management
Nirmish Shah, Thomas L. Ortel, and Sam Schulman

Chapter 107: Hemorrhagic Complications of Anticoagulation
Sam Schulman and Mark A. Crowther

Chapter 108: Heparin-Induced Thrombocytopenia
Theodore E. Warkentin and Andreas Greinacher

Chapter 109: Coumarin-Induced Skin Necrosis and Venous Limb Gangrene
Theodore E. Warkentin

Chapter 110: New Antithrombotic Drugs
Jeffrey I. Weitz and Peter L. Gross

Chapter 111: Antiplatelet Therapy
Carlo Patrono

Chapter 112: Thrombolytic Therapy
Victor J. Marder and Daphne B. Stewart

Chapter 113: Anticoagulant and Procoagulant Proteinsin the Animal Kingdom
Angelina Wei Ling Tan, Shiyang Kwong, and R. Manjunatha Kinia

Chapter 114: Mechanical Devices and Embolectomy
Hervé Decousus, Patrick Mismetti, and Nicolas Meneveau

PART V: Hemostatic and Thrombotic Disorders Associated with Systemic Conditions

Chapter 115: Overview of Special Clinical Groups
Victor J. Marder

Chapter 116: VTE during Pregnancy and with Hormonal Contraceptives
Saskia Middeldorp,Mathilde Nijkeuter, and Michiel Coppens

Chapter 117: Gestational Vascular Complications
Benjamin Brenner , Anat Aharon, Jean-Christophe Gris

Chapter 118: Maternal Hemostatic Disorders and Obstetric Hemorrhage
Philippe De Moerloose, Françoise Boehlen, and Jean Christophe Gris

Chapter 119: Developmental Hemostasis
Paul Monagle, Vera Ignatovic, and Leslie Roy Berry

Chapter 120: Bleeding in Neonates and Children
Anthony K. Chan, Elizabeth A. Chalmers, Sam Schulman, and Alan Michelson

Chapter 121: Venous and Arterial Thromboembolism in Children
Paul Monagle, M. Patricia Massicotte, and Anthony K. Chan

Chapter 122: Thrombotic Complications of Sickle Cell Disease
Kenneth I. Ataga and Elliott P. Vichinsky

Chapter 123: Thrombohemorrhagic Complications of Sepsis
Marcel Levi

Chapter 124: Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features
Gayani Tillekeratne, Jennifer Cohn, and Hillary Dunlevy

Chapter 125: Cancer-related Thrombosis
Anna Falanga, Agnes Y. Y. Lee, Frederick R. Rickles

Chapter 126: Hemostatic Abnormalities in Liver Disease
Charles S. Eby and Stephen H. Caldwell

Chapter 127: Hemostatic Abnormalities in Renal Disease
Miriam Galbusera, Giuseppe Remuzzi, and Patrizia Ondei

Chapter 128: Multtrauma Derangements in Hemostasis and Thrombosis
Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, and Mitchell Jay Cohen

Chapter 129: Blood Management in the Cardiovascular Surgery Patient
Lawrence Tim Goodnough and L. Henry Edmunds Jr.

Chapter 130: Thrombo-Hemorrhagic Events in the Elderly
Isabelle Mahe and Ludovic Drouet

NEW to the Sixth Edition…
• A new team of editors , each a leader in his field, assures you of fresh, authoritative perspectives.
• Full color throughout
• A companion website that offers full text online and an image bank.
• A new introductory section of chapters on basic sciences as related to the field
• Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.
• Overview chapters preceding each section address broad topics of general importance.