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Publication Date
November 26, 2012
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  • Description
    Hemostasis and Thrombosis , Sixth Edition

    Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.

    NEW to the Sixth Edition…
    • A new team of editors , each a leader in his field, assures you of fresh, authoritative perspectives.
    • Full color throughout
    • A companion website that offers full text online and an image bank.
    • A new introductory section of chapters on basic sciences as related to the field
    • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.
    • Overview chapters preceding each section address broad topics of general importance.
  • Specs
    Product Format
    HC-Printed Cover
    Trim Size
    10.875 x 8.375
    Publication Date
    November 26, 2012
  • Victor J. Marder MD
    Professor of Clinical Medicine, Director, Vascular Medicine Program, Los Angeles Orthopaedic Hospital/UCLA; Division of Hematology/Medical Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
    William C. Aird MD
    Associate Professor of Medicine, Beth Israel Deaconness Medical Center, Boston, MA
    Joel S. Bennett MD
    Professor of Medicine, University of Pennsylvania, Philadelphia, PA
    Sam Schulman MD
    Professor of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gilbert C. White II MD
    Executive Vice President for Research, Blood Center of Wisconsin, Milwaukee, WI 
  • Table of contents

    Part 1: Introduction to the Field of Hemostasis and Thrombosis

    Chapter 1. History of the Field
    William C. Aird and Gilbert C. White, II

    Chapter 2. Molecular Evolution of the Vertebrate Blood Coagulation System
    Marianne A. Grant and William C. Aird

    Chapter 3. Molecular and Clinical Genetics
    Lesley Everett, Karl C. Desch, and David Ginsburg

    Chapter 4: Coagulation Enzymology
    Sriram Krishnaswamy

    Chapter 5: Cell Biology, Protein Processing, and Cell Signaling
    Randal J. Kaufman and Laura Popolo

    Chapter 6: Cellular and Molecular Immunology
    Andrew H. Lichtman

    Chapter 7: Biostatistics and Epidemiology: The Basic Science of Clinical Research
    Kerry L. Lee


    Chapter 8: Overview of Basic Coagulation and Fibrinolysis
    Gilbert C. White, II, Victor J. Marder, Sam Schulman, William C. Aird, and Joel S. Bennett

    Chapter 9: The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression
    Dominic W. Chung, Wengfeng Xu, and Earl W. Davie

    Chapter 10: Genetics of Coagulation Proteins
    Rodney M. Camire and Paris Margaritis

    Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation
    George J. Broze, Jr. and James H. Morrissey

    Chapter 12: Factors V and VIII
    Randal J. Kaufman, Philip J. Fay, Laura Popolo, and Thomas L. Ortel

    Chapter 13: Structure and Function of von Willebrand Factor
    Sandra L. Haberichter and Robert R. Montgomery

    Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins
    Kanagasabai Vadivel, Amy E. Schmidt, Victor J. Marder, Sriram Krishnaswamy, and S. Paul Bajaj

    Chapter 15A: Factor XI
    Peter N. Walsh and David Gailani

    Chapter 15B:The Factor XII-driven Plasma Contact System
    Thomas Renne

    Chapter 16: Fibrinogen Structure and Function
    John W. Weisel and Carl-Erik Dempfle
    Chapter 17: Factor XIII
    Cédric Duval, Helen Philippou, and Robert A. S. Ariëns

    Chapter 18: Antithrombin and the Serpin Family
    Susan C. Bock

    Chapter 19: Protein C and S and Thrombomodulin System
    Laurent O. Mosnier and John H. Griffin
    Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis
    Nuala A. Booth and Nicola J. Mutch

    Chapter 21: Inhibitors of Fibrinolysis
    Björn Wiman and Anna Ågren


    Chapter 22: Overview of Platelet Structure and Function
    Joel S. Bennett and Gilbert C. White, II

    Chapter 23: Platelet Production: Cellular and Molecular Regulation
    Elisabeth Cramer Bordé and William Vainchenker

    Chapter 24: Megakaryocyte Structure and Platelet Biogenesis
    Joseph E. Italiano, Jr. and John H. Hartwig

    Chapter 25: Thrombopoietin
    Kenneth Kaushansky and Ian Hitchcock

    Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V
    Michael C. Berndt, and Robert K. Andrews

    Chapter 26B: Major Platelet Glycoproteins: GPIIB/IIIa
    Feng Ye and Mark H. Ginsberg

    Chapter 27: Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity
    Thomas J. Kunicki and Diane J. Nugent

    Chapter 28: The Basis for Platelet Adhesion
    Brian Savage and Zaverio M. Ruggeri

    Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis
    David L. Bark Jr., Warwick S. Nesbitt, Angus K.T. Wong, and Shaun P. Jackson

    Chapter 30: Platelets and Collagen
    Steve P Watson, Richard W Farndale, Masaaki Moroi, and Stephanie M Jung

    Chapter 31: Integrin αIIb β3 and Platelet Aggregation
    Ana Kasirer-Friede, Kamila Bledzka, Jun Qin, , Edward F. Plow, and Sanford J. Shattil

    Chapter 32: Molecular Basis for Platelet Secretion
    Shaojing Ye and Sidney W. Whitehart

    Chapter 33: Platelet Signal Transduction
    Charles S. Abrams and Lawrence F. Brass

    Chapter 34: Platelet Prostaglandin Metabolism
    Tilo Grosser and Garret A. FitzGerald

    Chapter 35: The Role of Platelets in Blood Coagulation
    Peter N. Walsh

    Chapter 36: Blood-Borne Microparticles
    José López and Swaminathan Murugappan

    William C. Aird

    Chapter 37: Overview of Vascular Biology
    William C. Aird

    Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis
    Aernout Luttun and Peter Carmeliet

    Chapter 39: Rheology and Vessel Wall Stress
    Peter F. Davies, Larry V. McIntire, and Juan M. Jiménez

    Chapter 40: Nitric Oxide
    Bradley A. Maron and Thomas Michel
    Chapter 41: Blood Vessel Wall in Health and Disease
    Keith R. Brunt, Sonya Hui, Jagdish Butany, and Mansoor Husain

    Chapter 42: Endothelial Cell Function
    William C. Aird

    Chapter 43: Role of Endothelium in Hemostasis
    Michael J. Krisinger and Edward M. Conway

    Chapter 44: Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway
    Wolfram Ruf

    Chapter 45: Heparin and Vascular Proteoglycans
    Douglas M. Tollefsen and Lijuan Zhang

    Chapter 46: Endothelial Cell-Blood Cell Interactions
    Klaus Ley

    Chapter 47: Leukocyte Function and Contribution to Disease
    Edith van de Vijver and Taco W. Kuijpers

    Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction
    Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel


    Chapter 49: Overview of Inherited Hemorrhagic Disorders
    Gilbert C. White, II, Harold R. Roberts, and Victor J. Marder

    Chapter 50: Differential Diagnosis of the Bleeding Patient
    Jill M. Johnsen and Barbara A. Konkle

    Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia
    Edward G.D. Tuddenham

    Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment
    J. Evan Sadler and David Lillicrap

    Chapter 53: Rare Inherited Coagulation Disorders Other than Hemophilia
    Pier Mannuccio Manucci, Massimo Franchini, and Flora Peyvandi

    Chapter 54: Afibrogenemias and Dysfibrogenemias
    Dennis K. Galanakis

    Chapter 55: Familial Multiple Coagulation Factor Deficiencies
    Bin Zhang and David Ginsburg

    Chapter 56: Clinical Disorders of Fibrinolysis
    Daphne Stewart, Charles W. Francis, and Victor J. Marder

    Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies
    Charles RM Hay

    Chapter 58: Laboratory Markers of Coagulation and Fibrinolysis
    Kenneth A. Bauer and Helen A. Ireland


    Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders
    Joel S. Bennett

    Chapter 60: Differential Diagnosis of Thrombocytopenia
    Joel S. Bennett andCharles S. Abrams

    Chapter 61: Immune Thrombocytopenic Purpuraand Posttransfusion Purpura
    Howard A. Liebman, Douglas B. Cines, and James B. Bussel

    Chapter 62: Drug-Induced Thrombocytopenia
    Richard H. Aster and James N. George

    Chapter 63: Inherited Thrombocytopenias
    Paquita Nurden and Alan T. Nurden

    Chapter 64: Acquired Nonimmune Thrombocytopenia
    Andreas Greinacher and Theodore E. Warkentin

    Chapter 65: Hereditary Disorders of Platelet Function
    Joel S. Bennett and A. Koneti Rao

    Chapter 66: Acquired Disorders of Platelet Function
    A. Koneti Rao and Joel S. Bennett

    Chapter 67: Laboratory Markers of Platelet Activation
    Paul Harrison and Alan D. Michelson


    Chapter 68: Overview of Primary Disorders of Blood Vessels
    William C. Aird

    Chapter 69: Disorders of Connective Tissue and Extracellulara Matrix
    Fransiska Malfait and Anne dePaepe Chapter 70: Hereditary Hemorrhagic Telangiectasia
    Michelle Letarte and Claire L. Shovlin

    Chapter 71: Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations
    Douglas A. Marchuk and Mark L. Kahn

    Chapter 72: Aneurysms (Large and Small Arteries)
    Carlos E. Sanchez, Sangita Kapur, and Neal L. Weintraub

    Chapter 73: Intracranial Hemorrhage
    Timolaos Rizos and Thorsten Steiner

    Chapter 74: Retinopathy
    Jing Chen, , Andreas Stahl, and Lois E.H. Smith


    Chapter 75: Overview to Therapy of Bleeding Disorders
    Gilbert C. White II

    Chapter 76: Management of Acute Hemorrhage
    Nigel S. Key, Micah J. Mooberry, and Rommer Lu

    Chapter 77: Therapy with Antifibrinolytic Agents
    Daphne B. Stewart and Victor J. Marder

    Chapter 78: Transfusion Medicine
    Thomas S. Kickler

    Chapter 79: New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy
    Gilbert C. White II and Harold R. Roberts



    Chapter 80. Overview of Venous Thromboembolism
    Sam Schulman, Victor J. Marder, and Gilbert C. White II

    Chapter 81: Thrombophilia Genetics
    Joseph Emmerich, Martine Aiach, and Pierre-Emmanuel Morange

    Chapter 82: Epidemiology and Risk Factors of Venous Thromboembolism
    John A. Heit

    Chapter 83: Clinical Manifestations and Diagnosis of Venous Thromboembolism
    Henri Bounameaux and Arnaud Perrier

    Chapter 84: Venous Thrombosis in Unusual Sites
    Victor J. Marder, Hylton V. Joffe, and Sam Schulman

    Chapter 85: Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension
    Vittorio Pengo and Susan R. Kahn

    Chapter 86: Prevention of Venous Thromboembolic Disease
    Menno V. Huisman, Ajay Kakkar, Pasha, and Patrick Mismetti

    Chapter 87: Treatment of Venous Thromboembolic Disease
    Sam Schulman, Jeffrey Ginsberg, and James Douketis


    Chapter 88: Overview of Arterial Thrombotic Disorders
    Sam Schulman and Victor J. Marder

    Chapter 89: Pathophysiology of Atherosclerosis
    Peter Libby, Paul M. Ridker, and Kevin Croce

    Chapter 90: Acute Coronary Syndromes: Manifestations and Management
    John Paul Vavalle, John H. Alexander, and Matthew T. Roe

    Chapter 91: Pathophysiology of Thromboembolic Stroke
    Emer R. McGrath and Martin J. O'Donnell

    Chapter 92: Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, Cardiomyopathy
    Thomas Kawano and Jonathan L. Halperin

    Chapter 93: Acute Stroke: General Management, Anticoagulant, and Thrombolytic Therapy
    Gregory J. del Zoppo and Jeffrey L. Saver

    Chapter 94: Medical and Surgical Treatment of Peripheral Arterial Disease
    Phillip Joseph, Saurabh Kalra, and Sonia Anand

    Chapter 95: Unusual Sites of Arterial Occlusion
    Philip A. Kalra,Jon G. Moss,and Peter Wiedemann

    Chapter 96: Pathogenesis and Treatment of Biomaterial-Associated Thrombosis
    Maud B. Gorbet and Michael V. Sefton


    Chapter 97: Overview of Microvascular and Complex Thrombotic Disorders
    Theodore E. Warkentine and Victor J. Marder

    Chapter 98: Consumptive Thrombohemorrhagic Disorders
    Marcel Levi, Donald I. Feinstein, Robert W. Colman, and Victor J. Marder

    Chapter 99: Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome-Microangiopathies

    Chapter 100: Vasculitides
    James R. Stone and John H. Stone

    Chapter 101: Antiphospholipid Antibodies and the Antiphospholipid Syndrome
    Jacob H. Rand and Lucia R. Wolgast

    Chapter 102: Thrombohemorrhagic Complications of Myeloproliferative Disorders
    Ayalew Tefferi

    Chapter 103: Thrombotic and Hemorrhagic Complications Associted with Stem Cell Transplantation
    Yona Nadir and Benjamin Brenner


    Chapter 104: Overview of Therapeutic Agents used in Thrombotic Disorders
    Sam Schulman and Victor J. Marder

    Chapter 105: Pharmacology and Mode of Action of Heparin and Glycosaminoglycans
    Meyer Michael Samama, Jeanine M. Walenga, Evi Kalodiki, and Jawed Fareed

    Chapter 106: Vitamin K Antagonists: Biochemistry, Pharmacology and Management
    Nirmish Shah, Thomas L. Ortel, and Sam Schulman

    Chapter 107: Hemorrhagic Complications of Anticoagulation
    Sam Schulman and Mark A. Crowther

    Chapter 108: Heparin-Induced Thrombocytopenia
    Theodore E. Warkentin and Andreas Greinacher

    Chapter 109: Coumarin-Induced Skin Necrosis and Venous Limb Gangrene
    Theodore E. Warkentin

    Chapter 110: New Antithrombotic Drugs
    Jeffrey I. Weitz and Peter L. Gross

    Chapter 111: Antiplatelet Therapy
    Carlo Patrono

    Chapter 112: Thrombolytic Therapy
    Victor J. Marder and Daphne B. Stewart

    Chapter 113: Anticoagulant and Procoagulant Proteinsin the Animal Kingdom
    Angelina Wei Ling Tan, Shiyang Kwong, and R. Manjunatha Kinia

    Chapter 114: Mechanical Devices and Embolectomy
    Hervé Decousus, Patrick Mismetti, and Nicolas Meneveau

    PART V: Hemostatic and Thrombotic Disorders Associated with Systemic Conditions

    Chapter 115: Overview of Special Clinical Groups
    Victor J. Marder

    Chapter 116: VTE during Pregnancy and with Hormonal Contraceptives
    Saskia Middeldorp,Mathilde Nijkeuter, and Michiel Coppens

    Chapter 117: Gestational Vascular Complications
    Benjamin Brenner , Anat Aharon, Jean-Christophe Gris

    Chapter 118: Maternal Hemostatic Disorders and Obstetric Hemorrhage
    Philippe De Moerloose, Françoise Boehlen, and Jean Christophe Gris

    Chapter 119: Developmental Hemostasis
    Paul Monagle, Vera Ignatovic, and Leslie Roy Berry

    Chapter 120: Bleeding in Neonates and Children
    Anthony K. Chan, Elizabeth A. Chalmers, Sam Schulman, and Alan Michelson

    Chapter 121: Venous and Arterial Thromboembolism in Children
    Paul Monagle, M. Patricia Massicotte, and Anthony K. Chan

    Chapter 122: Thrombotic Complications of Sickle Cell Disease
    Kenneth I. Ataga and Elliott P. Vichinsky

    Chapter 123: Thrombohemorrhagic Complications of Sepsis
    Marcel Levi

    Chapter 124: Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features
    Gayani Tillekeratne, Jennifer Cohn, and Hillary Dunlevy

    Chapter 125: Cancer-related Thrombosis
    Anna Falanga, Agnes Y. Y. Lee, Frederick R. Rickles

    Chapter 126: Hemostatic Abnormalities in Liver Disease
    Charles S. Eby and Stephen H. Caldwell

    Chapter 127: Hemostatic Abnormalities in Renal Disease
    Miriam Galbusera, Giuseppe Remuzzi, and Patrizia Ondei

    Chapter 128: Multtrauma Derangements in Hemostasis and Thrombosis
    Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, and Mitchell Jay Cohen

    Chapter 129: Blood Management in the Cardiovascular Surgery Patient
    Lawrence Tim Goodnough and L. Henry Edmunds Jr.

    Chapter 130: Thrombo-Hemorrhagic Events in the Elderly
    Isabelle Mahe and Ludovic Drouet

  • Features
    NEW to the Sixth Edition…
    • A new team of editors , each a leader in his field, assures you of fresh, authoritative perspectives.
    • Full color throughout
    • A companion website that offers full text online and an image bank.
    • A new introductory section of chapters on basic sciences as related to the field
    • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.
    • Overview chapters preceding each section address broad topics of general importance.
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