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November 26, 2012
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  • Description

    Hemostasis and Thrombosis, Sixth Edition


     Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.  


    NEW to the Sixth Edition…

    • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.

    • Full color throughout

    • A companion website that offers full text online and an image bank.

    • A new introductory section of chapters on basic sciences as related to the field

    • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.

    • Overview chapters preceding each section address broad topics of general importance.

  • Specs
    Product Format
    HC-Printed Cover
    Trim Size
    10.875 x 8.375
    Publication Date
    November 26, 2012
  • Victor J. Marder MD
    Professor of Clinical Medicine, Director, Vascular Medicine Program, Los Angeles Orthopaedic Hospital/UCLA; Division of Hematology/Medical Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
    William C. Aird MD
    Associate Professor of Medicine, Beth Israel Deaconness Medical Center, Boston, MA
    Joel S. Bennett MD
    Professor of Medicine, University of Pennsylvania, Philadelphia, PA
    Sam Schulman MD
    Professor of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gilbert C. White II MD
    Executive Vice President for Research, Blood Center of Wisconsin, Milwaukee, WI 
  • Features

    NEW to the Sixth Edition…

    • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.

    • Full color throughout

    • A companion website that offers full text online and an image bank.

    • A new introductory section of chapters on basic sciences as related to the field

    • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.

    • Overview chapters preceding each section address broad topics of general importance.

  • Table of contents





    Part 1: Introduction to the Field of Hemostasis and Thrombosis



    Chapter 1.  History of the Field

    William C. Aird and Gilbert C. White, II


    Chapter 2.  Molecular Evolution of the Vertebrate Blood Coagulation System

    Marianne A. Grant and William C. Aird


    Chapter 3.  Molecular and Clinical Genetics

    Lesley Everett, Karl C. Desch, and David Ginsburg


    Chapter 4:  Coagulation Enzymology

    Sriram Krishnaswamy


    Chapter 5: Cell Biology, Protein Processing, and Cell Signaling

    Randal J. Kaufman and Laura Popolo


    Chapter 6: Cellular and Molecular Immunology

    Andrew H. Lichtman


    Chapter 7:  Biostatistics and Epidemiology: The Basic Science of Clinical Research

    Kerry L. Lee





    Chapter 8: Overview of Basic Coagulation and Fibrinolysis

    Gilbert C. White, II, Victor J. Marder, Sam Schulman, William C. Aird, and Joel S. Bennett


    Chapter 9:  The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression

    Dominic W. Chung, Wengfeng Xu, and Earl W. Davie


    Chapter 10: Genetics of Coagulation Proteins

    Rodney M. Camire and Paris Margaritis


    Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation

    George J. Broze, Jr. and James H. Morrissey


    Chapter 12: Factors V and VIII

    Randal J. Kaufman, Philip J. Fay, Laura Popolo, and Thomas L. Ortel


    Chapter 13: Structure and Function of von Willebrand Factor

    Sandra L. Haberichter and Robert R. Montgomery


    Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins

    Kanagasabai Vadivel, Amy E. Schmidt, Victor J. Marder, Sriram Krishnaswamy, and S. Paul Bajaj


    Chapter 15A:  Factor XI

    Peter N. Walsh and David Gailani


    Chapter 15B: The Factor XII-driven Plasma Contact System

    Thomas Renne


    Chapter 16:  Fibrinogen Structure and Function

    John W. Weisel and Carl-Erik Dempfle

    Chapter 17: Factor XIII

    Cédric Duval, Helen Philippou, and Robert A. S. Ariëns


    Chapter 18: Antithrombin and the Serpin Family

    Susan C. Bock


    Chapter 19:  Protein C and S and Thrombomodulin System

    Laurent O. Mosnier and John H. Griffin

    Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis

    Nuala A. Booth and Nicola J. Mutch


    Chapter 21:  Inhibitors of Fibrinolysis

    Björn Wiman and Anna Ågren




    Chapter 22: Overview of Platelet Structure and Function

    Joel S. Bennett and Gilbert C. White, II


    Chapter 23:  Platelet Production: Cellular and Molecular Regulation

    Elisabeth Cramer Bordé and William Vainchenker


    Chapter 24: Megakaryocyte Structure and Platelet Biogenesis

    Joseph E. Italiano, Jr. and John H. Hartwig


    Chapter 25:  Thrombopoietin

    Kenneth Kaushansky and Ian Hitchcock 


    Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V

    Michael C. Berndt, and Robert K. Andrews


    Chapter 26B: Major Platelet Glycoproteins: GPIIb/IIIa

    Feng Ye and Mark H. Ginsberg


    Chapter 27:  Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity

    Thomas J. Kunicki and Diane J. Nugent


    Chapter 28: The Basis for Platelet Adhesion

    Brian Savage and Zaverio M. Ruggeri


    Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis

    David L. Bark Jr., Warwick S. Nesbitt, Angus K.T. Wong, and Shaun P. Jackson


    Chapter 30: Platelets and Collagen

    Steve P Watson, Richard W Farndale, Masaaki Moroi, and Stephanie M Jung


    Chapter 31: Integrin αIIb β3 and Platelet Aggregation

    Ana Kasirer-Friede, Kamila Bledzka, Jun Qin, , Edward F. Plow, and Sanford J. Shattil


    Chapter 32:  Molecular Basis for Platelet Secretion

    Shaojing Ye and Sidney W. Whitehart


    Chapter 33: Platelet Signal Transduction

    Charles S. Abrams and Lawrence F. Brass 


    Chapter 34:  Platelet Prostaglandin Metabolism

    Tilo Grosser and Garret A. FitzGerald


    Chapter 35:  The Role of Platelets in Blood Coagulation

    Peter N. Walsh


    Chapter 36:  Blood-Borne Microparticles

    José López and Swaminathan Murugappan



    William C. Aird


    Chapter 37:  Overview of Vascular Biology

    William C. Aird


    Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis

    Aernout Luttun and Peter Carmeliet


    Chapter 39: Rheology and Vessel Wall Stress

    Peter F. Davies, Larry V. McIntire, and Juan M. Jiménez


    Chapter 40:  Nitric Oxide

    Bradley A. Maron and Thomas Michel

    Chapter 41:  Blood Vessel Wall in Health and Disease

    Keith R. Brunt, Sonya Hui, Jagdish Butany, and Mansoor Husain


    Chapter 42:  Endothelial Cell Function

    William C. Aird


    Chapter 43:  Role of Endothelium in Hemostasis

    Michael J. Krisinger and Edward M. Conway


    Chapter 44:  Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway

    Wolfram Ruf


    Chapter 45:  Heparin and Vascular Proteoglycans

    Douglas M. Tollefsen and Lijuan Zhang


    Chapter 46: Endothelial Cell-Blood Cell Interactions

    Klaus Ley


    Chapter 47:  Leukocyte Function and Contribution to Disease

    Edith van de Vijver and Taco W. Kuijpers


    Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction

    Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel





    Chapter 49: Overview of Inherited Hemorrhagic Disorders

    Gilbert C. White, II, Harold R. Roberts, and Victor J. Marder


    Chapter 50:  Differential Diagnosis of the Bleeding Patient

    Jill M. Johnsen and Barbara A. Konkle 


    Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia

    Edward G.D. Tuddenham


    Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment

    J. Evan Sadler and David Lillicrap


    Chapter 53:  Rare Inherited Coagulation Disorders Other than Hemophilia

    Pier Mannuccio Manucci, Massimo Franchini, and Flora Peyvandi


    Chapter 54: Afibrogenemias and Dysfibrogenemias

    Dennis K. Galanakis


    Chapter 55: Familial Multiple Coagulation Factor Deficiencies

    Bin Zhang and David Ginsburg


    Chapter 56:  Clinical Disorders of Fibrinolysis

    Daphne Stewart, Charles W. Francis, and Victor J. Marder


    Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies

    Charles RM Hay


    Chapter 58:  Laboratory Markers of Coagulation and Fibrinolysis

    Kenneth A. Bauer and Helen A. Ireland




    Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders

    Joel S. Bennett


    Chapter 60: Differential Diagnosis of Thrombocytopenia

    Joel S. Bennett and Charles S. Abrams


    Chapter 61:  Immune Thrombocytopenic Purpuraand Posttransfusion Purpura

    Howard A. Liebman, Douglas B. Cines, and James B. Bussel


    Chapter 62: Drug-Induced Thrombocytopenia

    Richard H. Aster and James N. George


    Chapter 63: Inherited Thrombocytopenias

    Paquita Nurden and Alan T. Nurden


    Chapter 64: Acquired Nonimmune Thrombocytopenia

    Andreas Greinacher and Theodore E. Warkentin


    Chapter 65:  Hereditary Disorders of Platelet Function

    Joel S. Bennett and A. Koneti Rao


    Chapter 66: Acquired Disorders of Platelet Function

    A. Koneti Rao and Joel S. Bennett


    Chapter 67: Laboratory Markers of Platelet Activation

    Paul Harrison and Alan D. Michelson




    Chapter 68: Overview of Primary Disorders of Blood Vessels

    William C. Aird


    Chapter 69: Disorders of Connective Tissue and Extracellulara Matrix

    Fransiska Malfait and Anne dePaepeChapter 70: Hereditary Hemorrhagic Telangiectasia

    Michelle Letarte and Claire L. Shovlin


    Chapter 71: Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations

    Douglas A. Marchuk and Mark L. Kahn


    Chapter 72: Aneurysms (Large and Small Arteries)

    Carlos E. Sanchez, Sangita Kapur, and Neal L. Weintraub


    Chapter 73: Intracranial Hemorrhage

    Timolaos Rizos and Thorsten Steiner 


    Chapter 74: Retinopathy

    Jing Chen, , Andreas Stahl, and Lois E.H. Smith




    Chapter 75: Overview to Therapy of Bleeding Disorders

    Gilbert C. White II


    Chapter 76: Management of Acute Hemorrhage

    Nigel S. Key, Micah J. Mooberry, and Rommer Lu


    Chapter 77: Therapy with Antifibrinolytic Agents

    Daphne B. Stewart and Victor J. Marder


    Chapter 78: Transfusion Medicine

    Thomas S. Kickler


    Chapter 79: New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy

    Gilbert C. White II and Harold R. Roberts






    Chapter 80.  Overview of Venous Thromboembolism

    Sam Schulman, Victor J. Marder, and Gilbert C. White II


    Chapter 81: Thrombophilia Genetics

    Joseph Emmerich, Martine Aiach, and Pierre-Emmanuel Morange


    Chapter 82: Epidemiology and Risk Factors of Venous Thromboembolism

    John A. Heit


    Chapter 83: Clinical Manifestations and Diagnosis of Venous Thromboembolism

    Henri Bounameaux and Arnaud Perrier


    Chapter 84: Venous Thrombosis in Unusual Sites

    Victor J. Marder, Hylton V. Joffe, and Sam Schulman


    Chapter 85: Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension

    Vittorio Pengo and Susan R. Kahn


    Chapter 86: Prevention of Venous Thromboembolic Disease

    Menno V. Huisman, Ajay Kakkar, Pasha, and Patrick Mismetti


    Chapter 87: Treatment of Venous Thromboembolic Disease

    Sam Schulman, Jeffrey Ginsberg, and James Douketis




    Chapter 88: Overview of Arterial Thrombotic Disorders

    Sam Schulman and Victor J. Marder


    Chapter 89: Pathophysiology of Atherosclerosis

    Peter Libby, Paul M. Ridker, and Kevin Croce


    Chapter 90: Acute Coronary Syndromes: Manifestations and Management

    John Paul Vavalle, John H. Alexander, and Matthew T. Roe


    Chapter 91: Pathophysiology of Thromboembolic Stroke

    Emer R. McGrath and Martin J. O'Donnell


    Chapter 92: Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, Cardiomyopathy

    Thomas Kawano and Jonathan L. Halperin


    Chapter 93: Acute Stroke: General Management, Anticoagulant, and Thrombolytic Therapy

    Gregory J. del Zoppo and Jeffrey L. Saver  


    Chapter 94: Medical and Surgical Treatment of Peripheral Arterial Disease

    Phillip Joseph, Saurabh Kalra, and Sonia Anand


    Chapter 95: Unusual Sites of Arterial Occlusion

    Philip A. Kalra, Jon G. Moss, and Peter Wiedemann


    Chapter 96: Pathogenesis and Treatment of Biomaterial-Associated Thrombosis

    Maud B. Gorbet and Michael V. Sefton




    Chapter 97: Overview of Microvascular and Complex Thrombotic Disorders

    Theodore E. Warkentine and Victor J. Marder


    Chapter 98: Consumptive Thrombohemorrhagic Disorders

    Marcel Levi, Donald I. Feinstein, Robert W. Colman, and Victor J. Marder


    Chapter 99: Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome-Microangiopathies



    Chapter 100: Vasculitides

    James R. Stone and John H. Stone


    Chapter 101: Antiphospholipid Antibodies and the Antiphospholipid Syndrome

    Jacob H. Rand and Lucia R. Wolgast


    Chapter 102: Thrombohemorrhagic Complications of Myeloproliferative Disorders

    Ayalew Tefferi


    Chapter 103:  Thrombotic and Hemorrhagic Complications Associted with Stem Cell Transplantation

    Yona Nadir and Benjamin Brenner




    Chapter 104: Overview of Therapeutic Agents used in Thrombotic Disorders

    Sam Schulman and Victor J. Marder


    Chapter 105: Pharmacology and Mode of Action of Heparin and Glycosaminoglycans

    Meyer Michael Samama, Jeanine M. Walenga, Evi Kalodiki, and Jawed Fareed


    Chapter 106: Vitamin K Antagonists: Biochemistry, Pharmacology and Management

    Nirmish Shah, Thomas L. Ortel, and Sam Schulman


    Chapter 107: Hemorrhagic Complications of Anticoagulation

    Sam Schulman and Mark A. Crowther


    Chapter 108: Heparin-Induced Thrombocytopenia

    Theodore E. Warkentin and Andreas Greinacher


    Chapter 109: Coumarin-Induced Skin Necrosis and Venous Limb Gangrene

    Theodore E. Warkentin


    Chapter 110: New Antithrombotic Drugs
    Jeffrey I. Weitz and Peter L. Gross


    Chapter 111: Antiplatelet Therapy

    Carlo Patrono


    Chapter 112: Thrombolytic Therapy

    Victor J. Marder and Daphne B. Stewart


    Chapter 113: Anticoagulant and Procoagulant Proteinsin the Animal Kingdom

    Angelina Wei Ling Tan, Shiyang Kwong, and R. Manjunatha Kinia


    Chapter 114: Mechanical Devices and Embolectomy

    Hervé Decousus, Patrick Mismetti, and Nicolas Meneveau


    PART V:Hemostatic and Thrombotic Disorders Associated with Systemic Conditions


    Chapter 115: Overview of Special Clinical Groups

    Victor J. Marder


    Chapter 116: VTE during Pregnancy and with Hormonal Contraceptives

    Saskia Middeldorp, Mathilde Nijkeuter, and Michiel Coppens


    Chapter 117: Gestational Vascular Complications

    Benjamin Brenner, Anat Aharon, Jean-Christophe Gris


    Chapter 118: Maternal Hemostatic Disorders and Obstetric Hemorrhage

    Philippe De Moerloose, Françoise Boehlen, and Jean Christophe Gris


    Chapter 119: Developmental Hemostasis

    Paul Monagle, Vera Ignatovic, and Leslie Roy Berry


    Chapter 120: Bleeding in Neonates and Children

    Anthony K. Chan, Elizabeth A. Chalmers, Sam Schulman, and Alan Michelson


    Chapter 121: Venous and Arterial Thromboembolism in Children

    Paul Monagle, M. Patricia Massicotte, and Anthony K. Chan


    Chapter 122: Thrombotic Complications of Sickle Cell Disease

    Kenneth I. Ataga and Elliott P. Vichinsky


    Chapter 123: Thrombohemorrhagic Complications of Sepsis

    Marcel Levi


    Chapter 124: Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features

    Gayani Tillekeratne, Jennifer Cohn, and Hillary Dunlevy


    Chapter 125: Cancer-related Thrombosis

    Anna Falanga, Agnes Y. Y. Lee, Frederick R. Rickles


    Chapter 126: Hemostatic Abnormalities in Liver Disease

    Charles S. Eby and Stephen H. Caldwell


    Chapter 127: Hemostatic Abnormalities in Renal Disease

    Miriam Galbusera, Giuseppe Remuzzi, and Patrizia Ondei


    Chapter 128: Multtrauma Derangements in Hemostasis and Thrombosis

    Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, and Mitchell Jay Cohen


    Chapter 129: Blood Management in the Cardiovascular Surgery Patient

    Lawrence Tim Goodnough and L. Henry Edmunds Jr.


    Chapter 130: Thrombo-Hemorrhagic Events in the Elderly

    Isabelle Mahe and Ludovic Drouet







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