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Epilepsy: A Comprehensive Textbook

Edition: 3
9781975105525
ISBN/ISSN:
9781975105525
Publication Date:
November 17, 2023
2023-11-17
9781975105525
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Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics ...
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  • Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies. 
    • Offers a thorough discussion of epileptic seizure types and epilepsy syndromes, reflecting the latest research and knowledge throughout 

    • Discusses major advances in the understanding of the basic mechanisms of epilepsy and seizures, including an expanded section on their genetic etiologies, their consequences and co-occurring conditions. 

    • Presents state-of-the-art approaches for the diagnostic evaluation of individuals with seizures, pharmacotherapy and alternative treatments, and extensive discussions of the new antiseizure medications for managing seizure intensity and frequency, along with their side effects 

    • Covers the latest developments in surgical approaches to treatment, including neuromodulation 

    • Discusses psychiatric issues associated with epilepsy and conditions resembling seizures. 

    • Presents the current state of global health care delivery for individuals with epilepsy 

    • Shares the knowledge and expertise of contributing authors from 48 countries and nearly 300 institutions 
       

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  • Edition
    3
    ISBN/ISSN
    9781975105525
    Product Format
    Hardcover Multi-Volume Book
    Trim Size
    9.5 x 11.5
    Pages
    3998
    Edition
    3
    Publication Date
    November 17, 2023
    Weight
    19.45
  • Jerome Engel
    Solomon L. Moshe
  • VOLUME I
    SECTION 1 • EPIDEMIOLOGY AND
    PATHOLOGY OF SEIZURES AND EPILEPSY
    Section Editors: Alexis Arzimanoglou, Eleonora Aronica,
    Ettore Beghi, Ingmar Blümcke, Torbjörn Tomson,
    Harry V. Vinters, Solomon L. Moshé
    1 Overview: Epidemiology and Pathology of Seizures
    and Epilepsy 1
    Solomon L. Moshé, Alexis Arzimanoglou,
    W . Allen Hauser
    2 Epilepsy: Historical Perspectives 3
    Simon Shorvon, Peter Wolf
    3 Incidence and Prevalence of Seizures and Epilepsy 8
    W. Allen Hauser, Giorgia Giussani, Ettore Beghi
    4 Epidemiology of Epilepsy in Low- and Middle-Income
    Countries 17
    Charles R. Newton
    5 Etiology and Risk Factors for Seizures and Epilepsy 22
    Symon M. Kariuki, Dale C. Hesdorffer,
    Charles R. Newton
    6 The Comorbidities in Epilepsy 32
    Bastien Rioux, Carol Camfield, Josemir W. Sander,
    Mark R. Keezer
    7 Natural History and Prognosis of Epilepsy 45
    Ettore Beghi, Peter R. Camfield
    8 Epidemiology of Acute Symptomatic Seizures 54
    W. Allen Hauser, Giorgia Giussani, Ettore Beghi
    9 Seizure Precipitants 60
    Eylert Brodtkorb, Christian Samsonsen,
    Sheryl R. Haut
    10 The Mortality of Epilepsy 66
    Samden D. Lhatoo, Torbjörn Tomson
    11 General Neuropathology of Epilepsy 76
    Ingmar Blümcke
    12 Neuropathology of Hippocampal Sclerosis 80
    Maria Thom, Roland Coras
    13 Neuropathology of Developmental Disorders
    Associated With Epilepsy 88
    Harvey B. Sarnat, Ingmar Blümcke, Hajime Miyata,
    Harry V . Vinters
    14 Neuropathology of Brain Tumors Associated
    With Epilepsy 105
    Eleonora Aronica, Albert J. Becker,
    Angelika Mühlebner
    15 Neuropathology of Vascular Lesions Associated
    With Epilepsy 123
    Hajime Miyata, Eleonora Aronica
    SECTION 2 • GENETICS IN EPILEPSY
    Section Editors: Renzo Guerrini, Samuel F. Berkovic,
    Ruth Ottman, Jeffrey L. Noebels, Solomon L. Moshé
    16 Overview: Genetics in Epilepsy 141
    Aristea S. Galanopoulou, Renzo Guerrini
    17 Genetic Epidemiology in Epilepsy 142
    Colin A. Ellis, Ruth Ottman
    18 Genetic Architecture of the Epilepsies 154
    Karen L. Oliver, Samuel F. Berkovic
    19 Single Gene Epilepsies 160
    Valerio Conti, Renzo Guerrini
    20 How to Interpret and Act on Clinical Exomes
    in Epilepsy 174
    Yoshiteru Azuma, Naomichi Matsumoto
    21 Familial Epilepsies in the First Year of Life 180
    Monica Cooper, Mitsuhiro Kato
    22 Developmental and Epileptic Encephalopathies 185
    Amy McTague, Renzo Guerrini
    23 Genetic Generalized Epilepsies 199
    Antonietta Coppola, Carla Marini
    24 Genetic Encephalopathies With Epilepsy as a
    Main Feature 211
    Andreas Brunklaus, Danique R. M. Vlaskamp,
    Floor E. Jansen
    25 Genetic Testing and Counseling for the Epilepsies 223
    Melissa Wasserstein, Katie Gallagher , Beth Rosen Sheidley
    SECTION 3 • NEUROBIOLOGY OF EPILEPSY
    Section Editors: Istvan Mody, Annamaria Vezzani, Asla
    Pitkänen, Hal Blumenfeld, Ivan Soltesz, Jerome Engel Jr
    26 Overview: Neurobiology of Epilepsy 231
    Istvan Mody, Ivan Soltesz, Annamaria Vezzani,
    Jerome Engel Jr
    SUBSECTION 1 • NEURONS AND THEIR
    CIRCUITS RELEVANT TO EPILEPSIES
    27 Transcriptional Channelopathies in Genetic
    and Acquired Epilepsies 232
    Mala M. Shah, Douglas A. Coulter
    28 Principal Cell Heterogeneity in Malformations
    of Cortical Development and Acquired Epilepsy 241
    Fraser T. Sparks, Alfonso Represa, Attila Losonczy,
    Ivan Soltesz
    29 Mechanisms of Neuronal Excitation Leading
    to Synchrony 254
    Laura A. Ewell, Kevin J. Staley
    CONTENTSx Contents
    30 Interneuron Diversity in Epilepsy: Challenges
    and Progress 264
    Carolyn R. Houser, Scott C. Baraban, Günther Sperk
    31 Mechanisms of Neuronal Inhibition Leading
    to Synchrony 277
    Andrew Trevelyan, Kyle P. Lillis
    32 Neurons and Circuits During Brain Development 286
    Roustem Khazipov, Frances E. Jensen
    33 Metabolism, Reactive Oxygen Species, and Epilepsy 295
    Manisha Patel, Matthew Walker
    34 Dendritic Mechanisms of Excitability 300
    Heinz Beck, Yoel Yaari
    35 Thalamocortical Organization and Function:
    New Insights and Implications for Epilepsy 309
    Frances S. Cho, Jeanne T. Paz
    36 Mechanisms of Seizure Initiation and Propagation 321
    Steven Tobochnik, Pariya Salami, Sydney S. Cash,
    Catherine A. Schevon
    37 Seizures and Networks in the Human Focal Epilepsies:
    Beyond the Animal Models 335
    Fabrice Bartolomei, Vadym Gnatkovsky,
    Stanislas Lagarde, Marco de Curtis
    38 Temporal Coordination: A Key to Understand
    Cognitive and Behavioral Deficits in Epilepsy 344
    Pierre-Pascal Lenck-Santini, Liset Menendez de la Prida
    39 Epilepsy and Consciousness 361
    Fabrice Bartolomei, Hal Blumenfeld
    SUBSECTION 2 • TECHNICAL AND
    CONCEPTUAL ADVANCES FOR
    EPILEPSY RESEARCH
    40 Activating and Recording Neuronal Ensembles 377
    Marco Ledri, Fredrik Berglind, Merab Kokaia
    41 Genetically Encoded Probes for Optical Measurement
    of Neuronal Excitability and Synchrony 390
    Carlos Portera-Cailliau, Istvan Mody
    42 Fast Rhythms in Epilepsies 397
    Premysl Jiruska, Anatol Bragin, Richard J. Staba
    43 Miniaturized Microscopy as a Tool to Track Neuronal
    Population Dynamics in Epilepsy Models 410
    Daniel Aharoni, Peyman Golshani
    44 Seizure Control Through Closed-Loop Systems 423
    Martha L. Streng, Esther Krook-Magnuson
    45 Biomarkers 434
    Simona Balestrini, Asla Pitkänen, Matthias J. Koepp
    46 Comorbidities as Prognostic Factors for
    Epileptogenesis 454
    Wolfgang Löscher, Carl E. Stafstrom
    47 Use of Human Pluripotent Stem Cells in Epilepsy
    Research 465
    Jack M. Parent, Lori L. Isom
    SUBSECTION 3 • OTHER CONTRIBUTORS
    TO EXCESSIVE SYNCHRONY AND SEIZURES
    48 Novel Roles of Myelination in Neural Circuit Plasticity
    and Implications for Epilepsy 482
    Manasi Iyer, J. Bradley Zuchero
    49 Role of Dysfunctional Astrocytes in Epileptogenesis 495
    Christian Steinhäuser, Karen S. Wilcox
    50 Neurovascular Inflammation in Epilepsy 506
    Nicola Marchi, Annamaria Vezzani
    51 The Blood–Brain Barrier and Epilepsies 517
    E. A. van Vliet, Alon Friedman
    52 The mTOR Pathway in Epileptogenesis 523
    Emilio Russo, Michael Wong
    53 Epigenetic Mechanisms in Epilepsy 533
    Olivia R. Hoffman, Avtar Roopra, David C. Henshall
    54 Purinergic Signaling in Epilepsy 544
    Tobias Engel, Manvitha Kuchukulla, Detlev Boison
    55 Neurotrophic Factors in Epilepsy 554
    James O. McNamara, Michele Simonato
    56 Neurogenesis in Epilepsy 563
    Steve Danzer, Jenny Hsieh
    57 Somatic Mosaicism in Focal Malformations of
    Cortical Development 575
    Sara Baldassari, Katja Kobow, Stéphanie Baulac
    58 The Microbiota–Gut–Brain Axis and Epilepsy 582
    Stefanie Prast-Nielsen, John F. Cryan
    SECTION 4 • TRANSLATIONAL AND CLINICAL
    BIOLOGY OF SEIZURES AND EPILEPSY
    Section Editors: Aristea S. Galanopoulou, John M. Stern,
    Andrew G. Herzog, Mark Quigg, Sheryl R. Haut,
    Ivanka Savic, Terence J. O’Brien, Samden D. Lhatoo,
    Solomon L. Moshé, Jerome Engel Jr
    59 Overview: Translational and Clinical Biology
    of Seizures and Epilepsy 591
    Aristea S. Galanopoulou, John M. Stern
    60 Refinement of Rodent Models of Seizures and
    Epilepsy 593
    John G. R. Jefferys, Mark J. Prescott
    61 What do Models Model in Epilepsy? 600
    Aristea S. Galanopoulou, Solomon L. Moshé
    62 Translational Epilepsy Research: Progress, Challenges,
    and Future 611
    Aristea S. Galanopoulou, Jacqueline A. French,
    Terence J. O’Brien, Michele Simonato
    63 Age and Sex in the Neurobiology of Epilepsies
    in Animal Models 616
    Ozlem Akman, Kevin M. Kelly
    64 Gender in Clinical Biology of Epilepsy 632
    Barbara S. Koppel, Ivanka Savic
    65 Age and Clinical Biology of Epilepsy: Adults 637
    Joseph I. Sirven
    66 Age and Clinical Biology of Epilepsy: Infants 644
    Douglas R. Nordli Jr, Chalongchai Phitsanuwong
    67 Chronobiology of Epilepsy 650
    Philippa J. Karoly, Vikram R. Rao, Maxime Baud
    68 Sleep and Epilepsy 669
    Carl W. Bazil, Gordon F. Buchanan
    69 Breathing and Autonomic Disturbances During
    Seizures 685
    Nuria Lacuey Lecumberri, Brian D. Moseley,
    Samden D. Lhatoo
    70 Sudden Unexpected Death in Epilepsy (SUDEP) 700
    Philippe Ryvlin, Mark Stewart, Elizabeth J. Donner
    71 Stress and Epilepsy 716
    Ivanka Savic, Sheryl R. Haut, Marian Joëls
    72 Seizures and Epilepsy in General Medical Disorders 724
    Timothy E. Welty, David G. Vossler Contents xi
    73 Medical Conditions in Children With Epilepsy 743
    M. Scott Perry, Michael S. Duchowny
    74 Neurodegenerative Disorders and Epileptogenesis 751
    Victor Ferastraoaru, Patricia G. Saletti,
    Aristea S. Galanopoulou
    75 Anesthesia for Procedures in Patients With Epilepsy 762
    Susana Vacas, Barbara M. van de Wiele
    76 Hormone Changes in Epilepsy 771
    Catherine A. Christian-Hinman, Cynthia L. Harden
    77 Effects of Hormones on Seizure Expression 779
    Torbjörn Bäckström, David Bäckström, Suchitra Joshi
    78 Disorders of Reproduction and Fertility in Epilepsy 793
    Andrew G. Herzog, Jouko I. T. Isojarvi
    79 Sexuality in Epilepsy 806
    Susan Duncan, Oliver Henning
    80 Maternal Outcomes During Pregnancy in Women
    With Epilepsy 815
    Page B. Pennell, Torbjörn Tomson
    81 Consequences of Seizures 821
    Dipan C. Patel, Harald Sontheimer
    82 Drug Resistance in Epilepsy 832
    Wolfgang Löscher, Heidrun Potschka, Lina Jonsson,
    Sanjay M. Sisodiya, Annamaria Vezzani
    SECTION 5 • PHENOMENOLOGY OF SEIZURES
    Section Editors: Renzo Guerrini, John M. Stern, Peter
    Wolf, Robert S. Fisher, Philippe Kahane, Fernando
    Cendes, Aristea S. Galanopoulou, Jerome Engel Jr
    83 Overview: Phenomenology of Seizures 853
    Jerome Engel Jr, Solomon L. Moshé
    84 Classification of Epileptic Seizures 855
    Robert S. Fisher, Jerome Engel Jr
    85 Awareness in Seizures 866
    John M. Stern, Hal Blumenfeld
    86 Automatisms in Seizures 872
    Andreas Schulze-Bonhage, Laura Tassi
    87 Hyperkinetic Seizures 887
    Paolo Tinuper, Lino Nobili
    88 Autonomic Auras and Seizures 893
    Nuria Lacuey Lecumberri, James J. Riviello Jr,
    Samden D. Lhatoo
    89 Cognitive Seizures 899
    Elza Márcia Targas Yacubian, Peter Wolf
    90 Affective Seizures 908
    Khalil Ali, Tarek Ali, S. M. Amza Ali
    91 Neocortical Sensory Seizures 917
    Paul C. Van Ness, Ronald P . Lesser, Michael S. Duchowny
    92 Typical Absence Seizures 928
    Jeanne Benoit, Yoshimi Sogawa, William P . Welch,
    Pierre Thomas
    93 Atypical Absence Seizures 941
    Miguel A. Cortez, Christian M. Korff
    94 Myoclonic Absence Seizures 951
    Kenneth A. Myers, Gaetano Cantalupo,
    Carlo Alberto Tassinari
    95 Seizures With Eyelid Myoclonia 956
    Cristina Yip Go, O. Carter Snead III
    96 Atonic Seizures 963
    Roberto Michelucci, Hiroki Nariai
    97 Clonic Seizures 971
    Jillian L. Rosengard, Akio Ikeda
    98 Epileptic Spasms 974
    Lucia Fusco, Marta Elena Santarone, Puja Patel
    99 Myoclonic, Myoclonic–Atonic, and Myoclonic
    Tonic–Clonic Seizures 985
    Guido Rubboli, Hirokazu Oguni
    100 T onic Seizures 1007
    Kazuichi Yagi, Jillian L. Rosengard
    101 Generalized T onic–Clonic Seizures 1015
    Robert Beach, Shahram Izadyar, Samden D. Lhatoo
    102 Behavioral Arrest in Seizures 1023
    Juan G. Ochoa, Jorge Vidaurre
    103 Neonatal Seizures 1027
    Eli M. Mizrahi, Ronit M. Pressler
    104 Localizing and Lateralizing Value of Seizure
    Phenomenology 1043
    Jonathan M. Gursky, John M. Stern
    105 Status Epilepticus: Phenomenology and
    Pathophysiology 1050
    Shlomo Shinnar, Jaideep Kapur
    VOLUME II
    SECTION 6 • DIAGNOSTIC EVALUATION
    OF SEIZURES AND EPILEPSY
    Section Editors: Alexis Arzimanoglou, Susan Duncan,
    William Davis Gaillard, Sándor Beniczky,
    Prasanna Jayakar, Jean Gotman, Christoph Helmstaedter,
    Solomon L. Moshé
    106 Overview: Diagnostic Evaluation in Epilepsy 1057
    Solomon L. Moshé, Alexis Arzimanoglou
    107 History and Physical Examination in Epilepsy 1059
    Angélica Rivera-Cruz, Selim R. Benbadis
    108 Epilepsy Informatics 1065
    Zachary M. Grinspan, Wesley T. Kerr, Juma S.
    Mbwana, Daniel M. Goldenholz
    109 Laboratory Etiological Screening for Seizures 1074
    Cecilie Johannessen Landmark, Stéphane Auvin,
    Arjune Sen
    110 Physiological Basis of the Electroencephalogram
    and Local Field Potentials 1081
    György Buzsáki, Jennifer N. Gelinas
    111 Video-EEG Technologies, Montages, and
    Postprocessing in Epilepsy 1095
    Marc R. Nuwer, Frans Leijten, Alan D. Legatt
    112 Interictal Electroencephalography 1100
    Ushtar Amin, Selim R. Benbadis, Thaddeus Walczak,
    Prasanna Jayakar, Solomon L. Moshé
    113 Ictal Electroencephalography 1117
    Michael R. Sperling, Douglas R. Nordli Jr
    114 Polygraphic Recordings in Epilepsy 1131
    Carlo Alberto Tassinari, Elena Gardella, Gaetano
    Cantalupo, Guido Rubboli
    115 Home-Video EEG Monitoring in Epilepsy 1156
    Arpan Patel, Sushma Goyal, Fred Lado
    116 Standardized EEG Reporting 1164
    Sándor Beniczky, Alexis Boroxii Contents
    117 Electroencephalography in the Intensive Care Unit 1168
    Michael W. K. Fong, Lawrence J. Hirsch,
    Thomas P. Bleck
    118 Long-Term Monitoring in the Epilepsy Monitoring
    Unit 1182
    Alan D. Legatt, Julia M. Henry, Gregory K. Bergey,
    Douglas R. Nordli Jr
    119 Drug Withdrawal and Other Activating Techniques
    in Epilepsy 1192
    Sylvain Rheims, Kees P. J. Braun, Bruce J. Fisch,
    Elson L. So
    120 Electroencephalography and Magnetoencephalography
    Postprocessing in Epilepsy: Mapping, Source Imaging,
    and Dynamic Analysis 1199
    Sándor Beniczky, Pieter van Mierlo, Margitta Seeck
    121 Quantitative EEG Analysis and Automatic Event
    Detection 1216
    Shennan Aibel Weiss, Fernando Cendes, Jean Gotman
    122 Structural Neuroimaging in Epilepsy 1228
    Fernando Cendes, Graeme D. Jackson, William Davis
    Gaillard, Ruben I. Kuzniecky
    123 Positron Emission Tomography in Epilepsy 1258
    Matthias J. Koepp, Alexander Hammers
    124 Single Photon Emission Computed Tomography
    in Epilepsy 1285
    Elson L. So, Gregory D. Cascino, Terence J. O’Brien
    125 Magnetic Resonance Spectroscopy in Epilepsy 1295
    Jullie W. Pan, Ognen A. Petroff
    126 Functional Magnetic Resonance Imaging in Epilepsy 1301
    Zulfi Haneef, Robert C. Welsh, John M. Stern,
    Patricia D. Walshaw
    127 Seizure Prediction 1310
    Levin Kuhlmann, Klaus Lehnertz,
    Andreas Schulze-Bonhage
    128 EEG- and Non–EEG-Based Wearable Devices for
    Seizure Detection 1330
    Ilona Hubbard, Philippe Ryvlin, Sándor Beniczky
    129 Transcranial Magnetic Stimulation in Epilepsy 1335
    Melissa Tsuboyama, Roberto Michelucci, Mark Hallett,
    Alexander Rotenberg
    130 Neuropsychological Evaluation of Adults
    With Epilepsy 1345
    David W. Loring, William B. Barr, Bruce P. Hermann
    131 Neuropsychological Evaluation of Children
    With Epilepsy 1356
    Mary Lou Smith
    SECTION 7 • GENERAL TREATMENT
    CONSIDERATIONS IN EPILEPSY
    Section Editors: Jacqueline A. French, Lawrence J.
    Hirsch, Elaine C. Wirrell, Elinor Ben-Menachem,
    Daniel Friedman, Norman Delanty, Page B. Pennell,
    Eugen Trinka, Solomon L. Moshé
    132 Overview: General Approaches to Medical Treatment
    for Epilepsy 1361
    Emilio Perucca, Roger J. Porter
    133 When to Start Antiseizure Medication Therapy 1363
    Patricia Dugan, Chellamani Harini
    134 Management of Antiseizure Medication Initiation 1371
    Jeremy J. Moeller, Heidi M. Munger Clary,
    Lawrence J. Hirsch
    135 Matching Antiseizure Medications to the Patient 1376
    Tracey A. Milligan, Sanjay M. Sisodiya,
    Barbara A. Dworetzky
    136 Choice of Antiseizure Medications 1391
    Manisha G. Holmes, Elinor Ben-Menachem,
    Jacqueline A. French
    137 Measuring Treatment Response in the Epilepsy
    Clinic 1398
    David G. Vossler, Lara V. Marcuse
    138 Self-Management Strategies in Epilepsy—Beyond
    Antiseizure Medications 1411
    Robin E. McGee, Ross Shegog, Martha Sajatovic
    139 Pharmacist Roles in Interprofessional Team Care of
    People With Epilepsy and Approach to Care 1421
    Viet-Huong V. Nguyen, Jacquelyn L. Bainbridge,
    Sunita Dergalust
    140 Pharmacokinetics of Antiseizure Medications 1429
    Emilio Perucca, Piero Perucca
    141 Pharmacokinetic and Pharmacodynamic Drug-Drug
    Interactions in Epilepsy 1452
    Simona Lattanzi, Gaetano Zaccara, Patrick B. Moloney,
    Pasquale Striano
    142 Therapeutic Drug Monitoring in Epilepsy 1469
    Elisabeth Doran, Colin P. Doherty, Philip N. Patsalos
    143 Dose-Related Side Effects of Antiseizure
    Medications 1486
    Benjamin N. Blond, Jerry J. Shih
    144 Idiosyncratic Adverse Reactions from Antiseizure
    Medications 1494
    Gaetano Zaccara, David Ficker, Simona Lattanzi
    145 Long-Term Adverse Effects of Antiseizure
    Medications 1507
    Alison M. Pack, Barry E. Gidal
    146 Gender Issues For Drug Treatment in Epilepsy 1512
    Anne Sabers, Cynthia L. Harden
    147 Managing Antiseizure Medications Through
    Contraception and Pregnancy 1518
    P. Emanuela Voinescu, Angela K. Birnbaum
    148 Antiseizure Medications and Structural
    Teratogenesis 1524
    Elizabeth E. Gerard, Anna Serafini, Sanjeev V. Thomas
    149 Neurodevelopmental Effects of Antiseizure
    Medications 1540
    Eija Gaily, Kimford J. Meador
    150 Drug Treatment in Children With Epilepsy 1550
    Douglas R. Nordli Jr, Kelly G. Knupp,
    Jo M. Wilmshurst
    151 Drug Treatment in Adolescents With Epilepsy 1562
    Katherine Nickels, J. Helen Cross, Lieven Lagae
    152 Transition from Pediatric to Adult Care for People
    With Epilepsy 1569
    Danielle M. Andrade, Peter R. Camfield,
    Carol Camfield, Rima Nabbout
    153 Diagnosis and Treatment of Epilepsy in the
    Older Adult 1577
    Ilo E. Leppik, Eugen Trinka, Santoshi Billakota
    154 Treatment Adherence in Epilepsy 1588
    Avani C. Modi, Joyce A. Cramer, Shanna Guilfoyle Contents xiii
    155 Discontinuation of Antiseizure Medications 1598
    Dana Price, Dennis J. Dlugos, Ilo E. Leppik,
    Kamil Detyniecki
    156 Routine Monitoring for Safety and Tolerability
    During Chronic Treatment With Antiseizure
    Medications 1604
    Patricia Dugan, Peter Widdess-Walsh
    157 Combination Pharmacotherapy in Epilepsy 1613
    Frank G. Gilliam, R. Edward Faught
    158 Treatment of Single and Infrequent Seizures 1618
    Ettore Beghi, Emma Foster
    159 Treatment of Neonatal Seizures 1627
    Elissa G. Yozawitz, Ronit M. Pressler, Renée Shellhaas
    160 Febrile Seizures and Fever-Related Seizures 1639
    Nancy A. McNamara, Kollencheri Puthenveettil
    Vinayan
    161 Strategies When Treatments Fail in People With
    Epilepsy 1648
    Lara V. Marcuse, Matthias J. Koepp
    162 Managing Epilepsy in Patients With Medical
    Comorbidities 1654
    Daniel Costello, Christopher Elder, Alison M. Pack
    163 Prevention and Treatment of Provoked Seizures 1668
    Sarah Schmitt, Hiba A. Haider
    164 Ketogenic Diets for Epilepsy 1678
    Carl E. Stafstrom, Eric H. Kossoff, Jong M. Rho
    165 Reproductive Hormonal Treatment for Epilepsy 1689
    Andrew G. Herzog, Cynthia L. Harden
    166 Psycho-Behavioral Therapies in Epilepsy 1699
    Peter Wolf, Sheryl R. Haut, Rosa Michaelis
    167 Complementary and Alternative Medical
    Therapies for Epilepsy 1707
    Steven C. Schachter, Carlos Acevedo, Keryma Acevedo,
    Chi-Wan Lai, Amadou Gallo Diop
    SECTION 8 • ANTISEIZURE MEDICATIONS
    Section Editors: Jacqueline A. French, H. Steve White,
    Dennis J. Dlugos, Eugen Trinka, Martin J. Brodie,
    Barry E. Gidal, Solomon L. Moshé
    168 Overview: Antiseizure Medications 1715
    Jacqueline A. French, Elinor Ben-Menachem
    169 Epilepsy Pharmacogenetics and Pharmacogenomics 1718
    Isabelle Boothman, Gianpiero L. Cavalleri,
    Norman Delanty
    170 Screening of New Compounds and the Role of the
    Pharmaceutical Industry in Epilepsy 1732
    H. Steve White, Roger J. Porter, Henrik Klitgaard
    171 Investigational Drugs in Epilepsy 1749
    Michelle Guignet, Stephen Briggs, Gregory L. Krauss,
    H. Steve White
    172 Clinical Trials of Antiseizure Medications in Adults
    and Children 1771
    Jacqueline A. French, Tracy Glauser, Bernd Schmidt
    173 Seizure Rescue Therapy 1783
    Erin M. Fedak Romanowski, Howard P. Goodkin,
    Sucheta M. Joshi
    174 Adrenocorticotropic Hormone and Steroids
    in Epilepsy 1791
    Maria Roberta Cilio, Jules C. Beal, Federico Vigevano
    175 Brivaracetam 1801
    Bassel Abou-Khalil, Felix Rosenow
    176 Cannabidiol and Other Phytocannabinoids
    in Epilepsy 1813
    Samantha J. Hagopian, Eric D. Marsh, Daniel Friedman
    177 Carbamazepine 1819
    Francesco Brigo, Timothy E. Welty
    178 Cenobamate 1831
    Gregory L. Krauss, Steve Chung
    179 Clobazam and Other Benzodiazepines for
    Chronic Use 1840
    Francesco Brigo, Eugen Trinka, Simona Lattanzi
    180 Eslicarbazepine Acetate 1849
    Simona Lattanzi, Eugen Trinka, Martin J. Brodie
    181 Ethosuximide 1865
    Douglas R. Nordli Jr, Raj D. Sheth, William O. Tatum
    182 Everolimus in Epilepsy 1870
    Michael Kohrman, Zuhal Yapici, Michael Wong
    183 Felbamate 1886
    Elizabeth A. Felton, William H. Theodore
    184 Fenfluramine 1895
    Joseph Sullivan, Parthena M. Martin
    185 Immunotherapy in Epilepsy 1901
    Flavio Villani, Christian G. Bien, Lindsay M. Higdon,
    Giuliano Avanzini
    186 Lacosamide 1911
    Harold Kohn, Amber M. King, Raman Sankar
    187 Lamotrigine 1918
    Martin J. Brodie, Rajendra Kale, Barry E. Gidal
    188 Levetiracetam 1931
    Jennifer Cavitt, Simona Ferioli
    189 Oxcarbazepine 1947
    Jonathan Ross, Robert J. Kotloski, Pavel Klein
    190 Perampanel 1953
    Vicente Villanueva Haba, Alexandra Astner-Rohracher
    191 Phenobarbital and Barbiturate Prodrugs 1963
    Mervyn J. Eadie
    192 Phenytoin, Fosphenytoin, and Other Hydantoins 1975
    John M. Stern, Mervyn J. Eadie
    193 Pregabalin 1996
    Gregory K. Bergey, Lloyd E. Knapp
    194 Retigabine/Ezogabine 2009
    Stephan Arnold, Roger J. Porter
    195 Rufinamide 2017
    Maria-Cristina Cazacu, Alexander Rotenberg, Dana Craiu
    196 Stiripentol 2029
    Catherine Chiron, Rima Nabbout
    197 T iagabine 2039
    Reetta Kälviäinen
    198 T opiramate 2046
    David Gloss, R. Edward Faught
    199 Trimethadione, Paraldehyde, Phenacemide, Bromides,
    Sulthiame, Acetazolamide, and Methsuximide 2057
    John C. De Toledo
    200 V alproic Acid 2072
    Ahmad Beydoun, Wassim Nasreddine, Ronald C. Reed
    201 V igabatrin 2086
    Elinor Ben-Menachem, Catherine Chiron
    202 Zonisamide 2097
    Hyojin C. Suh, Sunita Dergalustxiv Contents
    VOLUME III
    SECTION 9 • SURGICAL THERAPY
    FOR EPILEPSY
    Section Editors: John M. Stern, Alexis Arzimanoglou,
    Philippe Kahane, Dennis D. Spencer, Michael R. Sperling,
    Samuel Wiebe, J. Helen Cross, Jerome Engel Jr
    203 Overview: Surgical Therapy for Epilepsy 2109
    John M. Stern, Jerome Engel Jr
    204 A Brief History of Epilepsy Surgery 2112
    Jerome Engel Jr
    205 Indications and Criteria for Epilepsy Surgery in
    Children 2123
    Cameron Elliott, Aswin Chari, Alexis Arzimanoglou,
    J. Helen Cross
    206 Indications and Criteria for Epilepsy Surgery
    in Adults 2131
    Robert C. Knowlton, Paul C. Van Ness
    207 Patterns of Epilepsy Surgery Referrals and Epilepsy
    Surgical Center Characteristics 2143
    Nathan B. Fountain, William Davis Gaillard
    208 Presurgical Evaluation for Epilepsy: General Principles
    and Methods 2148
    Fernando Cendes, Michael R. Sperling
    209 Intraoperative Electrocorticography in Epilepsy 2159
    Mark D. Holmes, Joyce Y. Wu
    210 Intraoperative Functional Mapping in Epilepsy 2175
    Patricia D. Walshaw, Susan Y. Bookheimer
    211 Extraoperative Procedures With Invasive Electrodes
    in Epilepsy 2183
    Brian Jung, Michael R. Sperling, Michael S. Duchowny,
    Philippe Kahane
    212 Intra-Arterial Anesthetic Procedures in Epilepsy 2209
    Marilyn Jones-Gotman, Mary Lou Smith
    213 EEG Biomarkers of Epileptogenic Region 2217
    Julia Jacobs, Maeike Zijlmans
    214 Invasive Monitoring Research Techniques
    in Epilepsy 2227
    Catherine A. Schevon, Richard J. Staba,
    Brett Youngerman
    215 Anesthesia for Epilepsy Surgery 2242
    Susana Vacas, Barbara M. van de Wiele
    216 Anterior Medial Temporal Resection for Epilepsy 2249
    Alexander Ksendzovsky, William Bingaman,
    Dennis D. Spencer
    217 Neocortical Resections for Epilepsy 2263
    Giorgio Lo Russo, Francesco Cardinale,
    Youssef G. Comair
    218 Insular Resections for Epilepsy 2282
    Marc Guénot, Philippe Ryvlin
    219 Hemispherectomy/Hemispherotomy and Multilobar
    Resections/Disconnections for Epilepsy 2286
    P. Sarat Chandra, Georg Dorfmüller
    220 Eloquent Cortex Surgery for Epilepsy 2327
    Shelly Wang, Jason Scott Hauptman, Toba Niazi
    221 Corpus Callosotomy for Epilepsy 2337
    Tomonori Ono, David W. Roberts
    222 Electrical Stimulation Treatments for Epilepsy 2344
    Brian Jung, Ana Luisa Velasco, John M. Stern,
    Dawn Eliashiv
    223 Ablative Procedures for Epilepsy: Laser Ablation,
    Stereotactic Radiosurgery, and Radiofrequency
    Ablation 2361
    Kunal Gupta, Mark Quigg, Robert E. Gross
    224 Epilepsy Surgery for Low-Grade Epilepsy Associated
    Tumors 2378
    Georgia Ramantani, Hans Holthausen
    225 Epilepsy Surgery for Malformations of Cortical
    Development 2389
    Aswin Chari, Martin M. Tisdall, Imad Najm
    226 Epilepsy Surgery for Vascular Lesions 2398
    Georgia Ramantani, Felix Rosenow
    227 Results of Surgery for Posttraumatic Epilepsy 2411
    P. Sarat Chandra, Raghu Samala
    228 Results of Epilepsy Surgery in Patients With
    Non-Lesional MRI 2418
    Kees P. J. Braun, Laura Tassi
    229 Surgery for Cerebral Infectious and Post-Encephalitic
    Epilepsy 2424
    William Muirhead, Christopher Uff, Neil Kitchen
    230 Surgery for Rasmussen Encephalitis 2437
    H. Westley Phillips, Jia-Shu Chen, Aria Fallah
    231 Epilepsy Surgery for Hypothalamic Hamartomas 2445
    Jeremy L. Freeman, A. Simon Harvey
    232 Measuring Epilepsy Surgery Outcomes 2450
    Samuel Wiebe, Monika Jones, Colin B. Josephson
    233 Adverse Effects of Epilepsy Surgery 2460
    Johan Bjellvi, Sallie Baxendale, Sareh Miranzadeh
    Mahabadi, Bertil Rydenhag, José F. Tellez-Zenteno
    234 Pre- and Postoperative Rehabilitation in Epilepsy
    Surgery 2468
    Erica K. Johnson, Sophia Macrodimitris
    235 Antiseizure Medication Withdrawal After Epilepsy
    Surgery 2483
    Kim Boshuisen, Morten I. Lossius
    236 Reoperation for Epilepsy 2489
    Luke D. Tomycz, Christopher Markosian,
    Robert R. Goodman
    SECTION 10 • PSYCHIATRIC ISSUES IN EPILEPSY
    Section Editors: Andres M. Kanner, Joan K. Austin,
    Marco Mula, Ivanka Savic, Jerome Engel Jr
    237 Overview: Psychiatric Issues in Epilepsy 2499
    Andres M. Kanner
    238 What Is a Psychiatric Symptom in Patients With
    Epilepsy? 2502
    Andres M. Kanner, Jay A. Salpekar
    239 Epidemiologic Aspects of Psychiatric Comorbidities
    in Epilepsy 2505
    Churl-Su Kwon, Nicolas Henao Romero, Nathalie
    Jetté, José F. Tellez-Zenteno
    240 Why Should Neurologists Care About Psychiatric
    Comorbidities in Patients With Epilepsy and the
    Obstacles for Their Care? 2513
    Andres M. Kanner, Marco Mula Contents xv
    241 Neurobiological Aspects of Epileptic Comorbidities:
    A Review of the Experimental Data 2518
    Aristea S. Galanopoulou, Andrey Mazarati,
    Quentin J. Pittman
    242 Mood Disorders in Adults With Epilepsy 2529
    Andres M. Kanner, Ramses Ribot, Marco Mula
    243 Suicidality and Epilepsy 2546
    Colin B. Josephson, Andres M. Kanner
    244 Aggressive Disorders in Epilepsy 2554
    Ludger Tebartz van Elst, Michael Trimble
    245 Anxiety Disorders in Adults With Epilepsy 2562
    Andres M. Kanner, Alan B. Ettinger
    246 Psychotic Disorders in Epilepsy 2578
    Marco Mula, Bettina Schmitz
    247 Personality and Personality Disorders in Epilepsy 2588
    Charlene N. Rivera-Bonet, Bruce P. Hermann,
    Orrin Devinsky, Scott E. Hirsch, Katee Yang,
    William B. Barr
    248 Intellectual Disabilities in Epilepsy 2598
    Gitta Reuner, Mary Lou Smith
    249 Autism and Epilepsy 2607
    Jamie K. Capal, Karen Ballaban-Gil, Sarah Spence
    250 Mood and Anxiety Disorders in Pediatric Patients
    With Epilepsy 2612
    Jana E. Jones, Jonathan Mietchen, Alanna Kessler-Jones,
    Grace J. Ma, Jeremy Mani, Jay A. Salpekar
    251 Attention Deficit Hyperactivity Disorder and
    Epilepsy 2625
    Jay A. Salpekar, David W. Dunn
    252 Psychiatric Symptoms of Antiseizure Medications 2634
    Marco Mula, Bettina Schmitz
    253 Psychiatric Iatrogenic Effects of Epilepsy Surgery 2640
    Steffi Koch-Stoecker, Kousuke Kanemoto
    254 Therapeutic Effects of Epilepsy Surgery on Presurgical
    Psychiatric Comorbidities 2649
    Luis Pintor, Hamada Hamid Altalib
    255 Do Psychiatric Comorbid Disorders Have an Impact
    on Postsurgical Seizure Outcome? 2654
    Rebecca Matthews, Andres M. Kanner
    256 Cognitive Adverse Effects of Antiseizure
    Medications 2658
    Sallie Baxendale, Corah Lewis, Lee Rusowicz,
    Gus A. Baker
    257 Pharmacologic Treatment of Psychiatric Disorders
    in Epilepsy: Basic Concepts 2665
    Marco Mula, Andres M. Kanner
    258 Psychotherapy in Epilepsy 2672
    Lorna Myers, Gaston Baslet
    259 The Use of Electroshock Therapy and Transcranial
    Magnetic Stimulation in Patients With Epilepsy: Safety
    and Therapeutic Considerations 2680
    Annya D. Tisher, Hamada Hamid Altalib, John J. Barry
    260 Psychiatry and Residential Care in Epilepsy 2686
    Stephen W. Brown, Frank M. C. Besag
    261 Overview: Social Issues in Epilepsy 2696
    Joan K. Austin, Robert T. Fraser
    262 Social Aspects in Epilepsy: Epilepsy Stigma and
    Quality of Life 2700
    Ann Jacoby, Dee Snape, Gus A. Baker
    263 Quality of Life in Children With Epilepsy 2711
    Avani C. Modi, Katherine F. Junger
    264 Quality of Life in Adults With Epilepsy 2719
    Wendy R. Miller, Jane R. von Gaudecker,
    Janice M. Buelow
    265 Self/Family Management in Pediatric Epilepsy: Overview
    and Utility in Routine Pediatric Epilepsy Care 2724
    Janelle L. Wagner, Gigi Smith
    266 Self-Management Programs for Adults With
    Epilepsy 2733
    Mimi Callanan, Elaine T. Kiriakopoulos, Joan K. Austin,
    Barbara C. Jobst
    267 Psychosocial Care Needs and Community Resources
    for People With Epilepsy 2746
    Joan K. Austin, Steven Owens
    268 The Range of Needs and Services in Vocational
    Rehabilitation in People With Epilepsy 2757
    Robert T. Fraser
    269 Epilepsy and Transition of Care 2771
    Rebecca J. Schultz, Jeffrey Buchhalter,
    Patricia O. Shafer
    270 Enhancing School Functioning and the School-to-Work
    Transition in Children With Epilepsy 2779
    Connie Sung, Wei-Mo Tu
    271 Issues in Health Outcomes Assessment in Epilepsy 2792
    Frank G. Gilliam, Mark A. Ferro, Samuel Wiebe
    272 Legal Concerns and Effective Advocacy Strategies
    in Epilepsy 2803
    Laura Weidner, Allison J. Nichol
    SECTION 11 • EPILEPSY SYNDROMES
    Section Editors: Renzo Guerrini, John M. Stern,
    Samuel F. Berkovic, Peter Wolf, Robert S. Fisher,
    Kate Riney, Aristea S. Galanopoulou, Jerome Engel Jr,
    Solomon L. Moshé
    273 Overview: Introduction to Epilepsy Syndromes 2811
    Elaine C. Wirrell, Paolo Tinuper, Solomon L. Moshé,
    Emilio Perucca
    274 Introduction to the Classification of Epilepsy 2813
    Jerome Engel Jr, Robert S. Fisher, Solomon L. Moshé
    275 Self-Limited (Familial) Neonatal Epilepsy 2817
    Ronit M. Pressler, Maurizio Taglialatela,
    Perrine Plouin, Henry Hasson
    276 Early Myoclonic Encephalopathy 2827
    Solomon L. Moshé, Nicola Specchio, Aleksandra
    Djukic, Federico Vigevano, Perrine Plouin
    277 Ohtahara Syndrome 2832
    Katsuhiro Kobayashi, Yoko Ohtsuka
    278 Self-Limited (Familial) Infantile Epilepsy 2838
    Federico Vigevano, Marina Trivisano, Nicola Specchio,
    Roberto Caraballo
    279 Epilepsy of Infancy With Migrating Focal
    Seizures 2844
    Lauren Sham, Phillip L. Pearl, Raman Sankar
    280 Infantile Epileptic Spasms Syndrome 2852
    Puja Patel, Marta Elena Santarone, Lucia Fusco
    281 Dravet Syndrome 2863
    Simona Balestrini, Renzo Guerrini
    282 Myoclonic Epilepsies in Infancy and Early
    Childhood 2870
    Renzo Guerrini, Simona Balestrinixvi Contents
    283 Hemiconvulsion-Hemiplegia-Epilepsy Syndrome 2877
    Marion Comajuan, Alexis Arzimanoglou,
    Eleni Panagiotakaki
    284 Self-Limited Epilepsy With Centrotemporal Spikes 2884
    Raman Sankar
    285 Childhood Occipital Visual Epilepsy and Self-Limited
    Epilepsy With Autonomic Seizures 2894
    Nicola Specchio, Giuseppe Gobbi, Renzo Guerrini,
    Salvatore Grosso
    286 Childhood and Juvenile Absence Epilepsies 2907
    Yoshimi Sogawa, William P. Welch, Jeanne Benoit,
    Pierre Thomas
    287 Epilepsy With Myoclonic Absences 2920
    Raman Sankar
    288 Lennox–Gastaut Syndrome 2924
    Mary Spiciarich, Kate Riney
    289 Encephalopathy Related to Status Epilepticus
    During Slow Sleep (ESES) Including Landau Kleffner
    Syndrome 2936
    Guido Rubboli, Koshi A. Cherian, Loreto Ríos-Pohl,
    Carlo Alberto Tassinari
    290 Rasmussen Syndrome 2948
    Manjari Tripathi, Gary Mathern
    291 Juvenile Myoclonic Epilepsy 2974
    Eliane Kobayashi, Fernando Cendes
    292 Generalized Tonic–Clonic Seizures Alone and
    Epilepsy With Generalized Tonic–Clonic Seizures
    on Awakening 2981
    Peter Wolf, Guido Rubboli
    293 Mesial Temporal Lobe Epilepsy With Hippocampal
    Sclerosis 2988
    Barbara C. Jobst, Jerome Engel Jr
    294 Familial Temporal Lobe Epilepsies 2994
    Fernando Cendes, Eliane Kobayashi,
    Iscia Lopes-Cendes
    295 Familial Frontal Lobe Epilepsies and Familial Focal
    Epilepsy With Variable Foci 3003
    Eliane Kobayashi, Dawn Eliashiv
    296 Gelastic Seizures and Hypothalamic
    Hamartomas 3013
    Jeremy L. Freeman, A. Simon Harvey
    297 Progressive Myoclonus Epilepsies 3019
    Jillian M. Cameron, Samuel F. Berkovic
    298 Posttraumatic Seizures 3028
    Daniel José Correa, Ramon Diaz-Arrastia
    299 Isolated Seizures 3043
    Peter Wolf, Elza Márcia Targas Yacubian
    300 Genetic Epilepsy With Febrile Seizures Plus 3052
    Iris Unterberger, Julia Höfler
    301 Reflex Epilepsies 3057
    Dorothée Kasteleijn-Nolst Trenité, Zeynep V. Okudan
    Atay, Çig ? dem Özkara
    302 Malformations of Cortical Development
    in Epilepsy 3064
    Renzo Guerrini, Elena Parrini
    303 Chromosomal Abnormalities in Epilepsy 3071
    Steffen Syrbe, Carla Marini
    304 Inherited Metabolic Disorders and Epilepsy 3081
    Douglas R. Nordli Jr, Darryl C. De Vivo
    305 Mitochondrial Diseases and Epilepsy 3098
    Hitoshi Osaka, Michio Hirano
    306 Seizures in Neonatal Hypoxic–Ischemic
    Encephalopathy 3110
    Eva Catenaccio, Courtney J. Wusthoff, Carl E. Stafstrom
    307 Central Nervous System Tumors and Seizures:
    Epidemiology, Diagnosis, and Management 3121
    Alireza Mansouri, Roberta Rudà, Michael Glantz
    308 Infectious Diseases and Seizures or Epilepsy 3132
    Oscar H. Del Brutto, Pierre-Marie Preux
    309 Acute Symptomatic Seizures Secondary to
    Autoimmune Encephalitis and Autoimmune-Associated
    Epilepsies 3143
    Sukhvir Wright, Claude Steriade, Angela Vincent
    310 Electrolyte, Sporadic Metabolic, and Endocrine
    Disorders in Epilepsy 3158
    Giuseppe Gobbi, Salvatore Grosso,
    Bernhard J. Steinhoff
    311 The Relationship of Alcohol and Substance
    Misuse/Abuse to Seizures and Epilepsy 3190
    Barbara S. Koppel
    312 Disorders of Pregnancy in Epilepsy 3200
    Barbara S. Koppel, Naymee J. Velez-Ruiz
    313 New-Onset Refractory Status Epilepticus and Febrile
    Infection-Related Epilepsy Syndrome 3205
    Nicola Specchio, Nicola Pietrafusa, Nicolas Gaspard
    SECTION 12 • DISORDERS THAT CAN
    RESEMBLE EPILEPSY
    Section Editors: Andres M. Kanner, W. Curt LaFrance Jr,
    Robert S. Fisher, Mark Hallett, Orrin Devinsky,
    Jerome Engel Jr
    314 Overview: Disorders that can Resemble Epilepsy 3223
    Andres M. Kanner
    315 Syncope Resembling Seizures 3225
    Halley Alexander, Mark Quigg
    316 Metabolic and Endocrine Disorders Resembling
    Seizures 3237
    Emily L. Johnson, Peter W. Kaplan
    317 Nonepileptic Neurologic Paroxysmal Disorders and
    Episodic Symptoms in Infants 3248
    Roberto Caraballo, Federico Vigevano
    318 Migraine Resembling Seizures 3259
    Sheryl R. Haut, Richard B. Lipton
    319 Cerebrovascular Disorders Resembling Seizures 3271
    Vasu Saini, Clinton B. Wright, Ralph L. Sacco
    320 Sleep and Epilepsy: Seizure Mimics and Sleep 3285
    Anne Marie Morse, Sanjeev V. Kothare
    321 Myoclonus and Myoclonic Syndromes 3294
    Mark Hallett
    322 Movement Disorders Resembling Seizures 3301
    Claire Miller, Giulietta M. Riboldi, Steven Frucht
    323 Movement Disorders: Dyskinesias 3308
    Steven Frucht, Pasquale Striano
    324 Sensory Disorders Resembling Seizures 3317
    Carl W. Bazil, Julien Hébert
    325 Other Neurologic Events Resembling Epileptic
    Seizures 3323
    Jason Margolesky, Alejandro A. Rabinstein
    326 Overview: Psychiatric Disturbances 3328
    Deana M. Gazzola, W . Curt LaFrance Jr, Orrin Devinsky Contents xvii
    327 Psychogenic Nonepileptic Seizures in Adults 3330
    W. Curt LaFrance Jr, Markus Reuber
    328 Psychogenic Nonepileptic Seizures in Pediatric
    Patients 3342
    Sigita Plioplys, Julia Doss
    329 Disorders of Impulse Control in Epilepsy 3346
    Ludger Tebartz van Elst, Michael Trimble
    330 Dissociative Disorders 3352
    Gaston Baslet, Lorna Myers
    331 Panic Disorder and Hyperventilation Syndrome 3363
    Alan B. Ettinger, Andres M. Kanner
    332 Obsessive-Compulsive Behavior 3375
    Mark S. George, Marco Mula
    333 Psychotic Symptoms Mimicking Epileptic Seizures 3380
    Maria Raquel Lopez, Frank W. Drislane
    SECTION 13 • DELIVERY OF HEALTH CARE
    IN PEOPLE WITH EPILEPSY
    Section Editors: Andres M. Kanner, Josemir W. Sander,
    Sarah Wilson, Nathalie Jetté, Martin J. Brodie,
    Chong Tin Tan, Solomon L. Moshé, Jerome Engel Jr
    334 Overview: Delivery of Health Care and Socioeconomic
    Issues in People With Epilepsy 3385
    Chong Tin Tan, Nathalie Jetté
    335 Epilepsy in Africa 3388
    Jo M. Wilmshurst, Angelina Kakooza-Mwesige,
    Lawrence Maskew Tucker
    336 Epilepsy in Argentina 3393
    Roberto Caraballo
    337 Epilepsy in Asia 3397
    Chong Tin Tan, Sanjeev V . Thomas
    338 Epilepsy in Brazil 3405
    Carlos A. M. Guerreiro, Elza Márcia Targas Yacubian
    339 Epilepsy in Canada 3416
    Jorge G. Burneo
    340 Epilepsy in the Caribbean 3421
    S. M. Amza Ali
    341 Epilepsy in Chile 3428
    Carlos Acevedo, Lilian Cuadra Olmos, Keryma Acevedo
    342 Epilepsy in China 3436
    Shichuo Li, Zhen Hong, Ding Ding, Yuping Wang,
    Dong Zhou, Guoming Luan, Jianguo Zhang,
    Jianxiang Liao, Dongning Wu, Liyun He, Jiong Qin,
    Yuwu Jiang, Wei-Ping Liao
    343 Epilepsy in Cuba 3452
    Lilia María Morales Chacón
    344 Epilepsy in the Czech Republic 3457
    Irena Doležalová, Ivan Rektor
    345 Epilepsy in Germany 3460
    Johann Philipp Zöllner, Adam Strzelczyk
    346 Epilepsy in India 3465
    Sanjeev V . Thomas, Satish Jain
    347 Epilepsy in Iran 3469
    Ali Gorji
    348 Epilepsy in Iraq 3474
    Ahmed Tahseen Muslim Al-Khazraji,
    Amro M. Abdulsattar, Hamada Hamid Altalib
    349 Epilepsy in Latin America 3477
    Roberto Caraballo, Marco T. Medina, Tomás Mesa
    Latorre
    350 Epidemiology of Epilepsy in Latin America 3483
    Jaime Carrizosa-Moog
    351 Epilepsy in Mexico 3488
    Iris E. Martínez-Juárez, Andrea Santos-Peyret,
    Daniel Crail-Meléndez
    352 Epilepsy in The Netherlands 3494
    Floor E. Jansen, Roland D. Thijs, H. J. Marian Majoie
    353 Epilepsy in Nigeria 3499
    Birinus Adikaibe Ezeala-Adikaibe
    354 Epilepsy in the Russian Federation 3509
    Alla Guekht, Dmitry Zhuravlev
    355 Epilepsy in Saudi Arabia 3513
    Raidah Saleem Albaradie
    356 Epilepsy in Scandinavia 3520
    Kristina Malmgren, Jakob Christensen,
    Morten I. Lossius
    357 Epilepsy in Senegal 3530
    Amadou Gallo Diop, Ibrahima Pierre Ndiaye,
    Ndiaga Matar Gaye
    358 Epilepsy in South Africa 3536
    Jo M. Wilmshurst, Ansuya Naidoo
    359 Epilepsy in South Korea 3545
    Byungin Lee
    360 Epilepsy in T unisia 3553
    Chahnez Charfi Triki, Fatma Kamoun Feki
    361 Epilepsy in T urkey 3562
    Bengi Gül Türk, Çig ? dem Özkara
    362 Epilepsy in the United Kingdom 3565
    Frank M. C. Besag, Arjune Sen, Michael J. Vasey,
    Stephen W . Brown
    363 Epilepsy in the United States of America 3574
    David M. Labiner
    364 Implementation Science for Epilepsy 3577
    Mary Jo Pugh, Hamada Hamid Altalib
    365 Social Media to Enhance Health Care Delivery
    and Education in Epilepsy 3583
    Daniel José Correa, Churl-Su Kwon
    Index I-1
    • Offers a thorough discussion of epileptic seizure types and epilepsy syndromes, reflecting the latest research and knowledge throughout 

    • Discusses major advances in the understanding of the basic mechanisms of epilepsy and seizures, including an expanded section on their genetic etiologies, their consequences and co-occurring conditions. 

    • Presents state-of-the-art approaches for the diagnostic evaluation of individuals with seizures, pharmacotherapy and alternative treatments, and extensive discussions of the new antiseizure medications for managing seizure intensity and frequency, along with their side effects 

    • Covers the latest developments in surgical approaches to treatment, including neuromodulation 

    • Discusses psychiatric issues associated with epilepsy and conditions resembling seizures. 

    • Presents the current state of global health care delivery for individuals with epilepsy 

    • Shares the knowledge and expertise of contributing authors from 48 countries and nearly 300 institutions 
       

    Enrich Your eBook Reading Experience 

    • Read directly on your preferred device(s), such as computer, tablet, or smartphone. 

    • Easily convert to audiobook, powering your content with natural language text-to-speech. 

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Epilepsy: A Comprehensive Textbook

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