Contents
Contributors vi
Foreword xv
Preface xvi
Preface to the First Edition xvii
PART 1:  GENERAL CONSIDERATIONS
Newborn Survival in a Global Context  1
Joy E. Lawn, Samantha Sadoo, Cally J. Tann,  
and Nahya Salim Masoud
The Scope and Organization of Perinatal Services: 
Global Comparisons and Challenges  16
Judy L. Aschner, Stephen W. Patrick, Ann R. Stark,  
and Shoo K. Lee
Newborn Intensive Care Unit Design: Scientific and 
Practical Considerations  29
Robert D. White, Judith A. Smith, and Gilbert I. Martin
Data Collection Systems for Service Evaluation and 
Research  34
Neena Modi
Quality Assessment and Improvement  40
Scott A. Lorch
Inter -Hospital T ransport  50
Hilary E. A. Whyte and Andrew Berry
Perinatal Medical Ethics, Decision-Making,  
and Legal Principles  69
Dominic J. C. Wilkinson, Gregory P. Moore,  
and Amir M. Zayegh
Care of the Family, Palliative Care, Brain Death,  
and Organ Donation  80
Krishelle L. Marc-Aurele
Discharge Planning, Follow-Up Care, and Outcome 
Evaluation  90
Angela Huertas-Ceballos and Katie Mckinnon
PART 2:  THE FETAL PATIENT
10 Prenatal Diagnosis and Management in the Molecular 
Age—Indications, Procedures, and Laboratory 
T echniques  109
Mark I. Evans, Dana Brabbing-Goldstein, Shara M. Evans, 
and Yuval Yaron
11 Multiple Gestation  137
Scott W. White
12 Placental Physiology, the In Utero Environment, and 
Antenatal Determinants of Disease  148
Ian P. Crocker
13 The Impact of Maternal Illness and Therapy  
on the Fetus and Neonate  155
Adalina Sacco, Sarah Guillon, and Anna L. David
14 The Impact of Prenatal Exposure to Nonnarcotic 
Drugs: Maternal, Fetal, Neonatal, and Long-T erm 
Outcomes  165
Enrique M. Ostrea Jr, Josef M. Cortez, Maria Esterlita T. 
Villanueva-Uy, and Jonathan M. Gamiao
 PART 3:  CARE AROUND BIRTH
15 T ransition and Stabilization  187
Ruben E. Alvaro
16 Delivery Room Management  201
Colm P. F. O’Donnell and Alan M. Groves
17 Physical Assessment and Classification  215
Leigh E. Dyet and Rose Crowley
18 Care of the Normal Newborn  238
Karen L. Kamholz and Jessica M. McGovern
 PART 4:  THE NEWBORN INFANT
19 Fluid and Electrolyte Management  251
Sabita Uthaya
20 Nutrition  258
Sara E. Ramel and Michael K. Georgieff
21 Radiology  278
Jeremy B. Jones
22 Health Care–Associated Infections  299
Joseph B. Cantey and Rebekah C. Gardea
23 Pharmacology  307
Mark A. Turner
24 Anesthesia and Analgesia  316
Sally H. Vitali
25 The Preterm Infant  326
Jayashree Ramasethu
26 The Small-for-Gestational Age Infant and IUGR  342
Bianca Carducci, Susan C. Campisi, Samia Aleem, and 
Zulfiqar A. Bhutta
27 Control of Breathing: Maturation and Associated 
Clinical Disorders  352
Nicole R. Dobson, Mark W. Thompson, and Carl E. Hunt
28 Acute Pulmonary Disorders  364
Jeffrey A. Whitsett, Amy T. Nathan, Shawn K. Ahlfeld, 
Gloria S. Pryhuber, and Paul S. Kingma29 Bronchopulmonary Dysplasia  386
Robin H. Steinhorn and Jonathan M. Davis
30 Surgical Management of the Airway and Lungs  400
Alison Maresh, Annie Harrington, Peter S. Midulla,  
and Vikash K. Modi
31 Hemodynamics  419
Patrick J. McNamara, Dany Weisz, Amish Jain,  
and Regan E. Giesinger
32 Structural Cardiac Disease and Cardiomyopathies  459
David Blundell, Caroline Jones, and David S. Crossland
33 Postoperative Management and Care of the Cardiac 
Surgical Patient  491
John M. Costello, Sinai C. Zyblewski, Jason R. Buckley, and 
Luke W. Schroeder
34 Disorders of Cardiac Rhythm  523
Luciana Marcondes and Jonathan R. Skinner
35 Development of Structure and Function of the 
Gastrointestinal T ract  536
Diomel M. de la Cruz and Josef Neu
36 Disorders of the Gastrointestinal T ract  546
Janice A. Taylor and Josef Neu
37 Hepatobiliary Disorders  564
Björn Fischler, Afrodite Psaros Einberg, and Maria 
Magnusson
38 Renal Disease  575
Suhas M. Nafday, Craig B. Woda, Jeffrey M. Saland, Joseph 
T. Flynn, David Askenazi, and Luc P. Brion
39 Structural Abnormalities of the Genitourinary  
T ract  623
Irene M. McAleer and Kai-wen Chuang
40 Endocrine Disorders  658
Penny M. Feldman and Mary M. Lee
41 Homeostasis of Carbohydrate and Other Fuels  678
J. M. Hawdon and James P. Boardman
42 Red Blood Cells and Their Disorders  695
Subarna Chakravorty and Irene Roberts
43 White Blood Cells and Their Disorders  708
Suneetha Desiraju and George J. Dover
44 Platelets and Disorders of Coagulation  714
Martha Sola-Visner and Matthew A. Saxonhouse
45 Neonatal Hyperbilirubinemia  731
Vinod K. Bhutani and Ronald J. Wong
46 Congenital Infections  748
Swetha G. Pinninti and David W. Kimberlin
47 Evaluation and Management of Infection in the 
Newborn  767
Miren B. Dhudasia, Dustin D. Flannery,  
and Karen M. Puopolo
48 Immunology  779
Kristin Scheible
49 Brain Injury at T erm  792
Andrew Whitelaw and Marianne Thoresen
50 Brain Development and Injury in Preterm Infants  804
David Edwards, Serena J. Counsell, and Pierre Gressens
51 Neonatal Seizures  819
Amanda G. Sandoval Karamian and Courtney J. Wusthoff
52 Neuromuscular Disorders  828
Eugenio Mercuri and Marika Pane
53 Neurosurgery  835
Kristian Aquilina
54 Neonatal Abstinence Syndrome  853
Hendrée E. Jones, Gerri R. Baer, and Jonathan M. Davis
55 Inherited Metabolic Disorders  861
Barbara K. Burton
56 Genetics and Genomics  872
Margo Sheck Breilyn and Bruce D. Gelb
57 Congenital Anomalies and Genetic Disease  877
Tara L. Wenger and Elizabeth J. Bhoj
58 Eye Disorders  891
Stacy L. Pineles and Sherwin J. Isenberg
59 Oncology  905
Lauren H. Boal and Howard J. Weinstein
60 Orthopedics  917
Deborah M. Eastwood
61 Dermatology  930
Kaiane A. Habeshian, Ha-young Choi,  
and Robert A. Silverman
Index 959