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Principles of Molecular Diagnostics and Personalized Cancer Medicine

9781451131970
ISBN/ISSN
9781451131970
Publication Date
January 9, 2013
2013-01-9
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9781451131970
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  • Description
    Principles of Molecular Diagnostics and Personalized Cancer Medicine'

    The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.
    Improve your understanding of…
    • The basic mechanisms of carcinogenesis— including material on cell proliferation, signal transduction pathways, cancer stem cells, and the interaction between genetics and environmental factors.
    • The most current molecular techniques —including polymerase chain reaction (PCR) technique, single nucleotide polymorphisms, cancer cytogenomics and epigenetics, whole-genome assessments, and next- generation sequencing.
    • Molecular tests —including molecular screening, minimal residual disease detection, circulating tumor cell tests, molecular tumor staging, and molecular cancer prognosis assessment.
    • Imaging and screening technologies —including molecular imaging, genetic tests, biostatistics, and bioinformatics.
    • The molecular basis of therapy —including critical molecules as special treatment targets, particularly genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles.
    • Molecular diagnostics – including updated molecular diagnostic approaches to common malignancies and role of pathology in targeted cancer management.
    • Targeted treatment – including personalized medicine and targeted therapy for commonly occurring malignancies— plus insights on new approaches to targeted drug discovery and the future of molecular oncology!
  • Specs
    ISBN/ISSN
    9781451131970
    Product Format
    HC-Printed Cover
    Trim Size
    8.375 x 10.875
    Pages
    992
    Illustration
    369
    Table
    80
    Publication Date
    January 9, 2013
    Weight
    5.7
  • Dongfeng Tan MD
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX
    Henry T. Lynch MD
  • Table of contents
    Dedication
    Contributors
    Preface

    Section I Introduction of Cancer Biology and Cancer Genetics
    Chapter 1
    Cell Proliferation and Apoptosis
    Laura B. Pitzonka and David W. Goodrich
    Chapter 2
    Cancer Stem Cells
    Sadhna Dhingra and Dongfeng Tan
    Chapter 3
    Cell Signal Transduction
    Markus Morkel
    Chapter 4
    Oncogenes
    Sadhna Dhingra and Dongfeng Tan
    Chapter 5
    Tumor Suppressor Genes
    Markus Reschke, Lev M. Kats, and Pier Paolo Pandolfi
    Chapter 6
    Viruses and Human Cancers: Pathogenesis and Therapeutic Implication
    Ih-Jen Su, Yao Chang, Grace Yu, and Charles Dwo-Yuan Sia

    Section II Molecular Techniques
    Chapter 7
    Introduction to Molecular Techniques and Instrumentation
    Shengle Zhang and Dongfeng Tan
    Chapter 8
    Transcriptome Analysis
    Shengle Zhang
    Chapter 9
    Immunohistochemistry
    Jeannelyn S. Estrella
    Chapter 10
    Cancer Genomic Sequencing
    Yingfei Wei and Guo-Liang Yu
    Chapter 11
    Mass Spectrometry: Principles and Applications in Cancer Diagnosis and Management
    Oliver J. Semmes, Richard R. Drake, and Julius O. Nyalwidhe
    Chapter 12
    Cancer Proteomics
    Kristin Huntoon and Zhengping Zhuang
    Chapter 13
    Morphoproteomics
    Robert E. Brown and Jamie J. Buryanek
    Chapter 14
    Flow Cytometry
    George Deeb
    Chapter 15
    Cancer Cytogenomics
    Gary Lu
    Chapter 16
    DNA Hypermethylation in Cancer
    Bin Yang
    Chapter 17
    Single Nucleotide Polymorphisms
    Qingyi Wei

    Section III Molecular Tests and Cancer Management
    Chapter 18
    Overview of Molecular Tests and Personalized Cancer Medicine
    Manuel Salto-Tellez
    Chapter 19
    Molecular Screening, Genetic Counseling, and Cancer Prevention: Lynch Syndrome as a Model
    Henry T. Lynch, Carrie L. Snyder, Jane F. Lynch, Stephen Lanspa, and Peter Silberstein
    Chapter 20
    Molecular Imaging and Cancer Management: PET and MR Agents for Molecular Imaging of Cancer Metabolism
    Yunkou Wu, Xiankai Sun, and A. Dean Sherry
    Chapter 21
    Detection and Molecular Monitoring of Minimal Residual Diseases in Myeloid Neoplasms
    C. Cameron Yin
    Chapter 22
    Molecular Assessment of Cancer Prognosis
    Qing Zhao and Dongfeng Tan
    Chapter 23
    Quality Control, Assurance, and Standardization of Molecular Diagnostics
    Matthew J. McGinniss, Ryan P. Bender, and Anatole Ghazalpour
    Chapter 24
    Biostatistics and Bioinformatics
    Qian Shi and Daniel J. Sargent
    Chapter 25
    In Vitro Companion Diagnostic and Anti-cancer Drug Co-development: Regulatory Perspectives
    Reena Philip, Elizabeth Mansfield, Lea Carrington, Yun-Fu Hu, and Maria Chan

    Section IV Molecular Diagnostics of Common Malignancies
    Chapter 26
    Molecular Biology and Pathology of Lung Cancer: Genotype–Morphology Correlation
    Yuichi Ishikawa and Osamu Matsubara
    Chapter 27
    Molecular Diagnostics of Breast Cancer
    Ping Tang and David G. Hicks
    Chapter 28
    Molecular Diagnostics of Colorectal Cancer
    Dongfeng Tan
    Chapter 29
    Molecular Diagnostics of Esophageal and Gastric Cancers
    Wataru Yasui, Naohide Oue, Kazuhiro Sentani, and Dongfeng Tan
    Chapter 30
    Molecular Biology of Prostate Cancer: Practical Considerations for Diagnosis and Prognosis
    David G. Bostwick
    Chapter 31
    Molecular Diagnostics of Hepatocellular Carcinoma
    Seung Kew Yoon, Hyun Goo Woo, Dongfeng Tan, and Yoon Jun Kim
    Chapter 32
    Molecular Diagnostics of Pancreatic Cancer
    Marco Dal Molin and Anirban Maitra
    Chapter 33
    Molecular Diagnostics of Head and Neck Cancer
    Adel K. El-Naggar
    Chapter 34
    Immunohistochemical and Molecular Diagnosis of Melanoma
    Andrea Suárez and Whitney A. High
    Chapter 35
    Molecular Diagnostics of Hematopoietic Neoplasms
    Qiulu Pan and Dan Jones
    Chapter 36
    Molecular Diagnostics of Lymphomas
    Keila Rivera-Roman and Christopher D. Gocke
    Chapter 37
    Molecular Diagnostics of Gynecologic Neoplasms
    Robert J. Kurman, Christina M. Bagby, and Ie-Ming Shih
    Chapter 38
    Molecular Diagnostics of Bladder and Kidney Cancers
    Hikmat A. Al-Ahmadie, Ying-Bei Chen, and Victor E. Reuter
    Chapter 39
    Molecular Diagnosis of Soft Tissue Sarcomas
    Jorge Torres-Mora and Andre M. Oliveira
    Chapter 40
    Molecular Diagnosis of Glioma
    Adriana Olar and Gregory N. Fuller
    Chapter 41
    Molecular Diagnostics of Pediatric Neoplasms
    Jennifer Picarsic, Marina Nikiforova, and Miguel Reyes-Múgica
    Chapter 42
    Molecular Diagnostics of Metastatic Malignancies
    Mikhail Lisovsky, Laura J. Tafe, and Joel A. Lefferts

    Section V Molecular Basis of Cancer Therapeutics
    Chapter 43
    DNA Repair and Cancer Therapeutics
    Mark R. Kelley and Melissa L. Fishel
    Chapter 44
    Monoclonal Antibodies for the Treatment of Cancer
    Jason C. Steel, Brian J. Morrison, and John C. Morris
    Chapter 45
    Vaccines and Cancer Therapy
    Joseph W. Kim and James L. Gulley
    Chapter 46
    Cancer Gene Therapy: Nucleic Acids as Therapeutic Agents
    Richard A. Morgan and Daniel Abate-Daga
    Chapter 47
    Anti-angiogenesis Therapy of Cancer
    Kun Guo and Keping Xie
    Chapter 48
    MicroRNAs and Cancer Therapeutics
    Maitri Y. Shah and George A. Calin
    Chapter 49
    Molecular Basis of Cancer Radiation Treatment
    Heath Skinner, Amit Deorukhkar, and Sunil Krishnan
    Chapter 50
    Nanotechnology and Cancer Therapy
    Chun Li
    Chapter 51
    New Approaches to Integration of Personalized Medicine in Early Cancer Drug Development
    Aik-Choon Tan, Stephen Leong, Todd M. Pitts, John J. Tentler, and S. Gail Eckhardt

    Section VI Personalized Medicine and Targeted Therapy of Cancer
    Chapter 52
    Personalized Medicine and Targeted Therapy of Lung Cancer
    Mary C. Pinder-Schenck and Scott J. Antonia
    Chapter 53
    Personalized Medicine and Targeted Therapy of Breast Cancer
    Komal Jhaveri, Chau Dang, and Clifford Hudis
    Chapter 54
    Personalized Medicine and Targeted Therapy for Colorectal Cancer
    Joleen M. Hubbard and Axel Grothey
    Chapter 55
    Personalized Medicine and Targeted Therapy of Esophageal Cancer
    Harry H. Yoon and Frank A. Sinicrope
    Chapter 56
    Personalized Medicine and Targeted Therapy of Gastric Cancer
    YingWei Xue, XueFeng Yu, and Yanqiao Zhang
    Chapter 57
    Personalized Medicine and Targeted Therapy for Prostate Cancer
    Madhuri Bajaj, Michael A. Carducci, and Elisabeth I. Heath
    Chapter 58
    Personalized Medicine and Targeted Therapy of Hepatocellular Carcinoma
    Jiang Hongchi, John W. Linford, and Ahmed O. Kaseb
    Chapter 59
    Personalized Medicine and Targeted Therapy of Pancreatic Cancer: Current Status and Proposed Strategies
    Milind Javle
    Chapter 60
    Personalized Medicine and Targeted Therapy of Neuroendocrine Neoplasms
    Jeana Garris and James C. Yao
    Chapter 61
    Personalized Medicine and Targeted Therapy of Head and Neck Cancer
    Ronald Myint, Kathryn A. Gold, and Edward S. Kim
    Chapter 62
    Personalized Medicine and Targeted Therapy for Melanoma
    Keith T. Flaherty
    Chapter 63
    Personalized Medicine and Targeted Therapy of Leukemia
    Pavan Kumar Bhamidipati, Elias Jabbour, and Jorge Cortes
    Chapter 64
    Personalized Medicine and Targeted Therapy of Gynecologic Cancers
    Lainie P. Martin and Russell J. Schilder
    Chapter 65
    Personalized Medicine and Targeted Therapy of Renal Cell Carcinoma
    C. Lance Cowey and Thomas E. Hutson
    Chapter 66
    Personalized Medicine and Targeted Therapy of Gliomas
    Brett J. Theeler, John De Groot, and W.K. Alfred Yung
    Chapter 67
    Personalized Medicine and Targeted Therapy for Osteosarcoma
    Jonathan Gill, David Geller, and Richard Gorlick
    Chapter 68
    Molecular Basis of Chemoradiotherapy and High-Precision Radiotherapy
    Michio Yoshimura, Masahiro Hiraoka, and Hiroshi Harada

    Section VII Future of Molecular Diagnostics and Personalized Cancer Medicine
    Chapter 69
    New Approaches to Personalized Medicine and Targeted Drug Discovery
    Garrett M. Dancik and Dan Theodorescu
    Chapter 70
    The Future of Molecular Diagnostics in Oncology
    Michael C. Dugan and Dongfeng Tan

    Index
  • Features
    Improve your understanding of…
    • The basic mechanisms of carcinogenesis— including material on cell proliferation, signal transduction pathways, cancer stem cells, and the interaction between genetics and environmental factors.
    • The most current molecular techniques —including polymerase chain reaction (PCR) technique, single nucleotide polymorphisms, cancer cytogenomics and epigenetics, whole-genome assessments, and next- generation sequencing.
    • Molecular tests —including molecular screening, minimal residual disease detection, circulating tumor cell tests, molecular tumor staging, and molecular cancer prognosis assessment.
    • Imaging and screening technologies —including molecular imaging, genetic tests, biostatistics, and bioinformatics.
    • The molecular basis of therapy —including critical molecules as special treatment targets, particularly genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles.
    • Molecular diagnostics – including updated molecular diagnostic approaches to common malignancies and role of pathology in targeted cancer management.
    • Targeted treatment – including personalized medicine and targeted therapy for commonly occurring malignancies— plus insights on new approaches to targeted drug discovery and the future of molecular oncology!
  • Review
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