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Principles and Practice of Pediatric Oncology

9781451194234
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9781451194234
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August 21, 2015
2015-08-21
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  • Description
    Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.

    BMA Medical Book Awards 2016​: Oncology – Highly Commended
    ​The British Medical Association honored Principles and Practice of Pediatric Oncology, 7th Edition with this prestigious award.

    Now thoroughly updated to include new advances in the field, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer as well as its diagnosis, multimodal treatment, as well as long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families.
    • Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.”
    • Chapters included on palliative care and education.
    • Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition.
    • Benefit from completely new and updated information throughout. 
    • The most updated and authoritative information is provided by the leading experts in the field.
    • Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy.
    • Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families.
    • Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
    Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:
    • Complete content with enhanced navigation
    • Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
    • Cross-linked pages, references, and more for easy navigation
    • A highlighting tool for easier reference of key content throughout the text
    • Ability to take and share notes with friends and colleagues
    • Quick reference tabbing to save your favorite content for future use
  • Specs
    Edition
    7
    ISBN/ISSN
    9781451194234
    Product Format
    HC-Printed Cover
    Trim Size
    8.375 x 10.875
    Pages
    1320
    Illustration
    647
    Table
    271
    Publication Date
    August 21, 2015
    Weight
    7.50
  • About The Author(s)
    Philip A. Pizzo MD
    Chief of Pediatrics, National Cancer Institute, Uniformed Services University for the Health Sciences, Bethesda, MD
    David G. Poplack MD
    Director, Texas Children's Cancer Center, Houston, TX
  • Features
    • Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.”
    • Reference your eBook version for key updates in the field during the life of the edition!
    • Chapters included on palliative care and education.
    • Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition.
    • Benefit from completely new and updated information throughout. 
    • The most updated and authoritative information is provided by the leading experts in the field.
    • Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy.
    • Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families.
    • Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
    Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:
    • Complete content with enhanced navigation
    • Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
    • Cross-linked pages, references, and more for easy navigation
    • A highlighting tool for easier reference of key content throughout the text
    • Ability to take and share notes with friends and colleagues
    • Quick reference tabbing to save your favorite content for future use
  • Table of contents
     
    SECTION 1
    BIOLOGICAL BASIS OF CHILDHOOD CANCER
            1  Epidemiology of Childhood Cancer 1
    Michael E. Scheurer, Philip J. Lupo, and Melissa L. Bondy
    Cancer Surveillance and Descriptive Epidemiology     1
    Analytic Epidemiology?????5
    Summary and Future Considerations?????10
            2  Childhood Cancer and Heredity 13
    Sharon E. Plon and David Malkin
    Constitutional Chromosomal Abnormalities?????13
    Structural Chromosomal Abnormalities?????14
    Overgrowth Disorders and Imprinting Errors?????15
    Autosomal Dominant Disorders?????16
    Autosomal Recessive Disorders?????25
    Issues in Genetic Testing for the Pediatric Oncology Patient?????28
            3  Molecular and Genetic Basis of Childhood Cancer 32
    Peter D. Aplan, Jack F. Shern, and Javed Khan
    Introduction?????32
    General Nature of Cancer-Associated Genetic Aberrations?????32
    Comprehensive Analysis of the Cancer Genome?????32
    Germline Mutations?????38
    Somatically Acquired Chromosomal Aberrations and Mutation?????40
    Gross Chromosomal Rearrangements?????40
    Oncogenic Consequences of Gross Chromosomal Rearrangements—General Themes?????41
    Chromosomal Translocations Lead to Activation of Proto-Oncogenes and Generation of Oncogenic Fusion Genes?????41
    Chromosomal Deletion Leads to Inactivation of Tumor Suppressor Genes?????48
    Gene Amplification?????50
    Point Mutations Leading to Gene Activation or Inactivation?????51
    Comprehensive Genomic Studies of Pediatric Tumors?????52
    Mechanisms of Malignant Cell Transformation, Growth, and Clonal Expansion?????55
    Outlook for Molecularly Targeted Therapies?????57
    Summary?????58
    Acknowledgments?????58
            4  Biology of Childhood Cancer 63
    Christopher Denny, Daniel S. Wechsler, and Kathleen M. Sakamoto
    Introduction?????63
    Signal Transduction?????63
    Gene Expression?????66
    Cell Cycle?????70
    Ubiquitin-Proteasome System?????72
    Programmed Cell Death?????74
    Tumor Microenvironment?????76
        5          Tumor Immunology and Pediatric Cancer 82
    Terry J. Fry, Paul M. Sondel, and Crystal L. Mackall
    Overview of the Immune System?????82
    Innate Immune Cells and the Tumor Microenvironment?????82
    T Lymphocytes and Co-Stimulation?????85
    B Lymphocytes?????87
    Natural Killer Cells?????88
    Immune Function in Cancer Patients?????89
    Modern Concepts of Immune Surveillance?????89
    Immunotherapy of Cancer?????90
    Summary and Future Directions?????98
    Acknowledgments?????98
    SECTION 2
    DIAGNOSIS AND EVALUATION OF THE CHILD WITH CANCER
        6          Clinical Assessment and Differential Diagnosis of the Child with Suspected Cancer 101
    Wendy Allen-Rhoades and Charles P. Steuber
    Introduction?????101
    Children at Risk?????101
    Time to Diagnosis?????102
    Differential Diagnosis?????102
    Establishing the Diagnosis?????109
    Summary?????111
        7          Pathology and Molecular Diagnosis of Leukemias and Lymphomas 113
    Amy Heerema-McKenney, Michael L. Cleary, and Daniel A. Arber
    Introduction?????113
    Specimen Processing?????113
    Use of Ancillary Studies?????113
    Acute Lymphoblastic Leukemia/Lymphoma (Precursor Lymphoid Neoplasms)?????114
    Acute Myeloid Leukemia?????117
    Myeloid Proliferations Related to Down Syndrome?????122
    Acute Leukemias of Ambiguous Lineage?????123
    Blastic Plasmacytoid Dendritic Cell Tumor?????123
    Myelodysplastic Syndromes and Myeloproliferative Neoplasms of?Childhood?????123
    Hodgkin Lymphoma?????124
    Non-Hodgkin Lymphoma of Childhood?????125
    Other Hematopoietic Tumors?????128
        8          Diagnostic Pathology of Pediatric Malignancies 131
    Timothy J. Triche, M. John Hicks, and Poul H. Sorensen
    Overview?????131
    Childhood Tumor Diagnosis?????136
    Molecular Genetic Evaluation of Childhood Cancer?????152
    Morphologic Versus Molecular Diagnosis of Cancer in Children?????163
    Beyond Classification: Diagnosis to Direct Therapy?????166
    Genome-Wide Analysis for Diagnosis, Prognosis, and Therapeutic Target Identification?????166
    The Future of Pediatric Cancer Diagnosis?????176

            9  Imaging Studies in the Diagnosis and Management of Pediatric Malignancies 185
    Rajesh Krishnamurthy, Heike E. Daldrup-Link, Jeremy Y. Jones, Stephan D. Voss, Geetika Khanna, Farahnaz Golriz, and Robert P. Guillerman
    Introduction?????185
    Relative Merits of Available Imaging Procedures?????185
    General Concepts of Pediatric Tumor Imaging?????199
    Future Directions?????233
    SECTION 3
    PRINCIPLES OF MULTIMODAL THERAPY
            10            General Principles of Chemotherapy 239
    Peter C. Adamson, Susan M. Blaney, Rochelle Bagatell,Jeffrey M. Skolnik, and Frank M. Balis
    Principles of Cancer Chemotherapy?????239
    Clinical Pharmacology of Anticancer Drugs?????241
    Alkylating Agents?????247
    Nonclassical Alkylating Agents?????261
    Antimetabolites?????265
    Purine Antimetabolites?????268
    Pyrimidine Antimetabolites?????272
    Topoisomerase Inhibitors?????274
    Tubulin Inhibitors?????281
    Small Molecule Pathway Inhibitors?????283
    Monoclonal Antibodies?????288
    Miscellaneous Agents?????289
    CNS Pharmacology of Anticancer Drugs?????294
    High-Dose Systemic Therapy for Meningeal and CNS Tumors?????296
    Perspectives?????296
            11            Molecularly Targeted Therapies and Biotherapeutics 316
    Malcolm A. Smith
    Introduction?????316
    Basic Principles for the Clinical Development of Molecularly Targeted Agents?????316
    Therapies Targeted to Apoptosis Pathways?????327
    Targeting Extracellular Survival Signaling Pathways?????329
    Targeting Janus Kinases (Jak)?????334
    Targeting the PI3K Pathway with Rapalogs and Other Inhibitors?????335
    Targeting Developmental Signaling Pathways?????336
    Targeting Mitotic Kinases and Kinesins?????336
    Targeting Histone Deacetylases?????337
    Targeting the Ubiquitin-Proteasome System?????338
    Targeting Angiogenesis?????339
    Conclusions?????340
            12            General Principles of Surgery 348
    Christopher B. Weldon, Thomas E. Hamilton, and Robert C. Shamberger
    Metabolic Response to Malignancy?????348
    Principles of Perioperative and Anesthetic Management?????349
    Management of?Pheochromocytomas/Paragangliomas?????352
    Cancer Surgery?????353
    Preoperative Adjuvant Therapy?????354
    Minimally Invasive Surgery?????359
            13            General Principles of Radiation Oncology 362
    Ralph P. Ermoian, Shannon E. Fogh, Steve Braunstein, Kavita K. Mishra, Larry E. Kun, and Daphne A. Haas-Kogan
    Biological Basis of Radiation Therapy?????362
    Physical Basis of Radiation Therapy?????365
        14        Adoptive Cellular Immunotherapy 383
    Stephen Gottschalk, Cliona M. Rooney, and Malcolm K. Brenner
    Introduction?????383
    Natural Killer Cells?????383
    γδ Thymus-Derived T Cells?????383
    Invariant NKT Cells?????384
    T Cells?????384
    Combinatorial Cell Therapy?????395
    Conclusions?????396
        15        Adolescents and Young Adults with Cancer 401
    Leonard S. Sender, Marcio H. Malogolowkin, and Keri B. Zabokrtsky
    Adolescents and Emerging Adults?????401
    Aya Classifications Around the World?????401
    Cancers Seen in AYA Patients?????402
    Cancers that Highlight Important AYA Considerations?????402
    Clinical Trials and AYAs?????411
    Psychosocial Aspects of AYA Oncology?????412
    Oncofertility?????413
    Support Services?????413
        16        Hematopoietic Stem Cell Transplantation in Pediatric Oncology 419
    Stephen Gottschalk, Swati Naik, Meenakshi Hegde, Catherine M. Bollard, Robert A. Krance, and Helen E. Heslop
    Introduction?????419
    Allogeneic Transplantation?????419
    Autologous Transplantation?????420
    Source of HSCs?????420
    Transplant for Leukemia?????421
    Hodgkin Lymphoma and Non-Hodgkin Lymphoma?????429
    Transplantation for Solid Tumors?????430
    Complications After Stem Cell Transplantation?????432
    Regimen-Related Toxicity?????434
    Late Complications of Stem Cell Transplantation?????435
    Future Directions?????436
        17        Cancer Clinical Trials: Design, Conduct, Analysis, and Reporting 441
    Susan G. Hilsenbeck, Lisa R. Bomgaars, and Stacey L. Berg
    Planning a Clinical Trial?????441
    Managing the Clinical Trial?????447
    Reporting Results of Clinical Trials?????450
        18        Maximizing Safety in Cancer Treatment 452
    Brigitta U. Mueller and Amy L. Billett
    Introduction?????452
    Background?????452
    Recognizing and Reporting of Problems?????454
    Preventing Errors?????455
    SECTION 4
    MANAGEMENT OF COMMON CANCERS OF CHILDHOOD
        19        Acute Lymphoblastic Leukemia 463
    Karen R. Rabin, Maria M. Gramatges, Judith F. Margolin, and David G. Poplack
    Introduction?????463
    Epidemiology?????463
    Genetics?????465
    Pathogenesis?????466
    Classification of ALL?????468
    Molecular Genetics of ALL?????469
    Clinical Presentation?????478
    Prognostic Factors?????481

    Treatment?????483
    Treatment of Relapse?????488
    Late Effects of Treatment?????491
    Future Challenges?????493
            20            Acute Myeloid Leukemia and Myelodysplastic Syndromes 498
    Robert J. Arceci and Soheil Meshinchi
    Historical Background and Definitions?????498
    Epidemiology of Pediatric AML and MDS?????498
    Biological Basis of AML and MDS: From Normal Progenitors to Leukemia?????499
    Familial and Acquired Causes of MDS/AML in Children?????500
    Methodologies for Classifying Myeloid Malignancies?????505
    Defining Subtypes: Evolution of Diagnostic Classification of Myeloid Malignancies?????508
    AML in Children?????514
    Prognostic Factors and Implications of Risk Group Stratification on Treatment?????516
    Unique AML Subtypes and Settings?????530
    The Treatment of Relapsed and/or Refractory AML?????533
    Survivorship?????535
            21            Myeloproliferative Neoplasms of Childhood 545
    Rachel Rau and Mignon L. Loh
    Chronic Myeloid Leukemia?????545
    Juvenile Myelomonocytic Leukemia?????559
    PV and ET?????563
            22            Hodgkin Lymphoma 568
    Monika L. Metzger, Matthew J. Krasin, John K. Choi, and Melissa M. Hudson
    Epidemiology?????568
    Biology?????569
    Pathology?????570
    Clinical Presentation?????572
    Differential Diagnosis?????572
    Diagnostic Workup?????572
    Staging?????573
    Treatment?????574
    Nodular Lymphocyte-Predominant HL?????581
    Future Considerations?????584
            23            Malignant Non-Hodgkin Lymphomas in Children 587
    Carl E. Allen, Kala Y. Kamdar, Catherine M. Bollard, and Thomas G. Gross
    Introduction?????587
    Overall Incidence/Epidemiology?????587
    Precursor Lymphomas?????589
    Mature B-Cell Lymphomas?????592
    Burkitt Lymphoma?????592
    Diffuse Large B-Cell Lymphoma?????596
    Primary Mediastinal Large B-Cell Lymphoma?????598
    Rare Mature B-Cell Lymphomas?????598
    Anaplastic Large Cell Lymphoma?????599
    Mature T-Cell Lymphomas?????600
    Conclusions?????600
    Management Summary?????601
            24            Lymphoproliferative Disorders and Malignancies Related to Immunodeficiencies 604
    Robert J. Hayashi, Birte Wistinghausen, and Bruce Shiramizu
    Introduction?????604
    Viral Pathogens and the Development of Malignancies?????604
    Epstein-Barr Virus and Malignancies?????604
    HHV-8 and Malignancies in Immunodeficient Patients?????605
    Malignancies in Primary Immunodeficiencies?????606
    Secondary Immunodeficiency and Cancer?????609
    Malignancies in the Posttransplant Patient?????610
    Summary?????614
        25        Histiocytic Diseases 617
    Kenneth L. McClain, Carl E. Allen, and M. John Hicks
    Introduction?????617
    Langerhans Cell Histiocytosis?????617
    Hemophagocytic Lymphohistiocytosis?????622
    Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease)?????624
    Juvenile Xanthogranuloma?????624
    Malignant Histiocytic Diseases?????625
    Summary?????626
    Management Summary?????626
        26A      Gliomas, Ependymomas, and Other Nonembryonal Tumors of the Central Nervous System 628
    D. Williams Parsons, Ian F. Pollack, Daphne A. Hass-Kogan, Tina Y. Poussaint, Adekunle M. Adesina, and Murali M. Chintagumpala
    Epidemiology?????628
    Inherited Syndromes Associated with CNS Tumors?????628
    Other Factors Associated with CNS Tumors?????629
    Pathologic Classification of CNS Tumors?????630
    Clinical Presentation?????631
    Neuroimaging in Pediatric CNS Tumors: Current Status and Future Directions?????633
    Neurosurgery: Diagnosis and Treatment?????636
    Radiation Therapy?????638
    Principles of Chemotherapy?????642
    Ependymoma?????643
    Low-Grade Gliomas?????645
    Tumors of the Optic Pathway?????649
    Supratentorial High-Grade Gliomas?????651
    Brainstem Gliomas?????653
    Craniopharyngioma?????657
    Choroid Plexus Neoplasms?????659
    Intramedullary Spinal Cord Tumors?????661
    Sequelae of Treatment?????662
        26B     Embryonal and Pineal Region Tumors 671
    Murali M. Chintagumpala, Arnold Paulino, Ashok Panigrahy, Cynthia Hawkins, Andrew Jae, and D. Williams Parsons
    Embryonal Tumors?????671
    Supratentorial PNETs?????683
    Atypical Teratoid/Rhabdoid Tumor?????686
    Pineal Region Tumors?????688
    Pineoblastomas?????690
    Germ Cell Tumors?????691
        27        Retinoblastoma 700
    Richard L. Hurwitz, Carol L. Shields, Jerry A. Shields, Patricia Chévez-Barrios, Dan S. Gombos, Mary Y. Hurwitz, and Murali M. Chintagumpala
    Introduction?????700
    Epidemiology?????700
    Genetics?????700
    Clinical Presentation?????702
    Diagnosis?????702
    Pathology?????705
    Metastasis and Recurrence?????710
    Trilateral Retinoblastoma and Other Tumors?????711
    Staging?????712
    Therapeutic Options?????715
    Histopathologic Changes Associated with Treatment?????722
    Research Directions?????722
        28        Liver Tumors 726
    Rebecka L. Meyers, Angela D. Trobaugh-Lotrario, Marcio H. Malogolowkin, Howard M. Katzenstein, Dolores H. López-Terrada, and Milton J. Finegold
    Historical Context?????726
    Differential Diagnosis?????726
    Epithelial Tumors?????727

    Mixed Epithelial/Mesenchymal or Uncertain Origin?????744
    Mesenchymal Tumors: Malignant?????745
    Mesenchymal Tumors: Malignant/Other?????746
    Metastatic and Other Malignant Liver Tumors?????748
            29            Renal Tumors 753
    Conrad V. Fernandez, James I. Geller, Peter F. Ehrlich, D. Ashley Hill, John A. Kalapurakal, and Jeffrey S. Dome
    Introduction?????753
    Epidemiology?????753
    Genetics and Molecular Biology?????753
    Pathology?????755
    Clinical Presentation and Diagnostic Workup?????757
    Prognostic Factors?????758
    Treatment of Wilms Tumor?????759
    Clear-Cell Sarcoma of the Kidney?????766
    Malignant Rhabdoid Tumor?????767
    Renal Cell Carcinoma?????768
    Congenital Mesoblastic Nephroma?????768
    Acknowledgments?????768
            30            Neuroblastoma 772
    Garrett M. Brodeur, Michael D. Hogarty, Rochelle Bagatell, Yael P. Mossé, and John M. Maris
    Introduction?????772
    Incidence and Epidemiology?????772
    Genetic Predisposition?????773
    Molecular Pathogenesis?????773
    Pathology?????777
    Clinical Presentation?????777
    Clinical and Laboratory Evaluation?????779
    Staging and Treatment Response?????780
    Prognostic Considerations?????782
    Principles of Initial Therapy?????785
    Treatment of Recurrent Disease?????790
    Late Effects?????792
    Future Considerations?????792
    Acknowledgments?????792
            31            Rhabdomyosarcoma 798
    Leonard H. Wexler, Stephen X. Skapek, and Lee J. Helman
    Epidemiology and Genetic Susceptibility?????798
    Molecular Biology?????799
    Animal Models?????799
    Pathology?????800
    Patterns of Spread and Clinical Presentation?????802
    Methods of Diagnosis?????806
    Staging?????807
    Prognostic Considerations?????808
    Treatment?????810
    Perspectives?????821
            32            The Nonrhabdomyosarcoma Soft Tissue Sarcoma 827
    Sheri L. Spunt, Lynn Million, and Cheryl Coffin
    Introduction?????827
    Epidemiology?????827
    Pathology?????828
    Clinical Presentation?????828
    Prognostic Factors?????829
    Staging?????830
    General Treatment Considerations?????830
    Radiation Therapy?????832
    Chemotherapy?????834
    Selected Specific Diseases (Listed by Biologic Potential and in Alphabetical order)?????836
    Intermediate, Locally Aggressive Soft Tissue Tumors?????836
    Intermediate, Rarely Metastasizing Soft Tissue Tumors?????842
    Malignant Soft Tissue Tumors?????845
    Late Effects of Therapy?????851
    Future Directions?????851
        33        Ewing Sarcoma 855
    Douglas S. Hawkins, Bernadette M. D. Brennan, Tobias Bölling, Darin J. Davidson, Uta Dirksen, Steven G. DuBois, Pancras C. W. Hogendoorn, and Stephen L. Lessnick
    Introduction and Epidemiology?????855
    Nomenclature?????855
    Biology?????855
    Clinical Presentation and Staging?????859
    Pathology?????861
    Initial Treatment?????863
    Recurrent Disease: Novel Treatment Strategies?????871
    Late Effects?????872
    Summary and Conclusions?????872
        34        Osteosarcoma 877
    Richard Gorlick, Katherine Janeway, and Neyssa Marina
    Introduction?????877
    Clinical Presentation?????877
    Epidemiology?????881
    Pathology?????884
    Biology?????885
    Treatment?????889
    Future Directions?????895
    Follow-Up and Late Effects?????896
        35        Germ Cell Tumors 899
    A. Lindsay Frazier, Thomas A. Olson, Dominik T. Schneider, Elizabeth J. Perlman, and James F. Amatruda
    Nomenclature?????899
    Embryogenesis and Histogenesis of Gonadal Tumors?????899
    Genetics and Molecular Biology?????900
    Pathology?????902
    Tumor Markers?????905
    Clinical Presentation and Staging?????906
    Treatment Overview?????909
    Ovarian Tumors?????914
    Testicular Tumors?????915
    Extragonadal Tumors?????915
    Salvage Strategies?????916
    Toxicity and Late Effects?????916
    Future Considerations?????917
        36        Endocrine Tumors 919
    Steven G. Waguespack, Winston W. Huh, and Andrew J. Bauer
    Introduction?????919
    Pituitary Tumors?????919
    Parathyroid Tumors?????925
    Thyroid Tumors?????926
    Gastoenteropancreatic Neuroendocrine Tumors?????933
    Adrenal Tumors?????936
    Pheochromocytoma and Paraganglioma?????939
        37        Rare Pediatric Tumors 946
    Carlos Rodriguez-Galindo, Wayne L. Furman, and Alberto S. Pappo
    Introduction?????946
    Cancer of the Aerodigestive Tract and Related Anatomical Sites?????946
    Cancer of the Lungs, Heart, and Thymus?????952
    Cancer of the Digestive Tract?????954
    Cancer of the Pancreas?????957
    Rare Cancers of the Genitourinary System?????958
    Cancer of the Skin?????959
    Other Rare Pediatric Cancers?????961

    SECTION 5
    SUPPORTIVE CARE OF CHILDREN WITH CANCER
            38            Oncologic Emergencies 967
    Jason L. Freedman, Susan R. Rheingold, and Michael J. Fisher
    Cardiothoracic Emergencies?????967
    Gastrointestinal Emergencies?????971
    Genitourinary Emergencies?????975
    Neurologic Emergencies?????976
    Vascular, Metabolic, and Endocrine Emergencies?????982
    Therapy-Associated Emergencies?????988
            39            Hematologic Supportive Care for Children with Cancer 992
    Jennifer Andrews, Susan A. Galel, Wendy Wong, and Bertil Glader
    Anemia?????992
    Thrombocytopenia?????994
    Acknowledgment?????1007
            40            Infectious Complications in Pediatric Cancer Patients 1010
    Monica I. Ardura and Andrew Y. Koh
    Host Defenses: Innate and Adaptive Immunitiy?????1010
    Care of Febrile Cancer Patients?????1013
    Empirical Antibacterial Treatment of Febrile, Neutropenic Patients?????1015
    Antifungal Agents?????1021
    Antiviral Agents?????1024
    Anti-Pneumocystis Pneumonia Agents?????1027
    Management of Unexplained Fever in the Neutropenic Patient?????1027
    Evaluation and Management of Documented Infections?????1029
    Prevention of Infection in Children with Cancer?????1046
    Prophylactic Antibiotics?????1046
    Immunization?????1048
    Granulocyte Transfusions?????1050
    Recombinant Human Cytokines?????1050
    Adoptive T-Cell Therapy?????1052
    Future Directions?????1053
            41            Nutritional Supportive Care 1058
    Sonia A. Ballal, Lori J. Bechard, and Christopher Duggan
    Introduction?????1058
    Definition of Cancer Cachexia?????1058
    Obesity and the Pediatric Patient with Cancer?????1059
    The Population at Risk?????1059
    Etiology and Pathophysiology?????1059
    Clinical Assessment of Nutritional Status?????1060
    Nutrition Intervention Techniques?????1062
    Vitamins in Treating the Pediatric Patient with Cancer?????1064
    Nutritional Concerns of Long-Term Survivors of Childhood Cancer?????1065
    Conclusion?????1065
            42            Pain and Symptom Management 1067
    Elliot J. Krane, Jacqueline Casillas, and Lonnie K. Zeltzer
    Overview of Childhood Cancer?????1067
    What is Pain??????1067
    Pain in Children: How Does it Differ from that in Adults??????1069
    Pain in Children: Can it be Quantitated??????1070
    Cancer Pain in Children?????1072
    Treatment of Pain in Pediatric Cancer Patients?????1072
    Drugs for Pain Management?????1076
    Interventional Procedures for Pain Management?????1083
    Side Effects and Symptoms in Pediatric Cancer Patients?????1085
    Summary?????1092
        43        Nursing Support of the Child with Cancer 1094
    Marilyn J. Hockenberry, Nancy E. Kline, and Cheryl Rodgers
    Direct Patient Care Nursing Roles?????1094
    Advanced Practice Roles?????1094
    Research Roles?????1095
    Nursing Standards of Care?????1095
    Providing Expert Clinical Nursing Care?????1095
    Professional Development?????1105
        44        Rehabilitation of the Child with?Cancer 1108
    David W. Pruitt, Mary A. McMahon, and Susan D. Apkon
    Rehabilitation Problems?????1110
    Specific Childhood Cancers: Rehabilitation Issues?????1113
        45        Psychiatric and Psychosocial Support for the Child and Family 1124
    Lori S. Wiener, Maryland Pao, Melissa A. Alderfer
    Principles and Essential Knowledge for Health Professionals?????1124
    Initial Diagnostic Period: A Time of Crisis?????1124
    Relapses and Recurrences: A Second Crisis?????1131
    Survivorship?????1134
    Family Considerations?????1135
    Psychosocial and Psychiatric Interventions?????1137
    Final Word?????1138
        46        The Other Side of the Bed: What Caregivers Can Learn from Listening to Patients and Their Families 1141
    Stephen J. Chanock, Vikas Kundra, Nancy Goodman, and Mary D. Singer
    Introduction?????1141
    General Issues of Communication and Trust?????1141
    Major Events in the Care of Patients and their Families?????1148
    Conclusion?????1154
    Acknowledgments?????1155
        47        Ethical Considerations in Pediatric  Oncology 1156
    Steven Joffe, Jennifer Kesselheim, and Susan Shurin
    Introduction?????1156
    Informed Consent?????1156
    Ethics of Research Involving Human Participants?????1158
    Ethical Issues at the End of Life?????1163
    Privacy and Confidentiality?????1165
    Genetics and Genomics?????1166
    Financial Incentives and Conflict of Interest?????1167
    SECTION 6
    OTHER ISSUES ARISING AT DIAGNOSIS, DURING TREATMENT, AND AFTER CESSATION OF THERAPY
        48        Late Effects of Childhood Cancer and its Treatment 1173
    Wendy Landier, Saro H. Armenian, Anna T. Meadows, and Smita Bhatia
    Burden of Morbidity?????1173
    Knowledge about Past Diagnosis and Treatment?????1173
    Standardized Recommendations for Follow-up of Childhood Cancer?????1173
    Auditory, Ocular, Oral, and Dental Complications?????1178
    Neurocognitive Sequelae?????1179
    Cardiovascular Function?????1180

    Pulmonary Function?????1181
    Genitourinary Abnormalities?????1182
    Gastrointestinal Function?????1182
    Thyroid Abnormalities?????1183
    Gonadal Function?????1183
    Growth?????1185
    Obesity?????1186
    Musculoskeletal and Related Tissues?????1186
    Subsequent Malignant Neoplasms?????1189
    Late Mortality Among Childhood Cancer Survivors?????1191
    Cancer Survivorship—Future Research Opportunities?????1191
            49            Educational Issues for Children with Cancer 1197
    Laurie D. Leigh, Heather M. Conklin, and Jane E. Schreiber
    The Importance of School Reentry Intervention?????1197
    Phases of School Reentry?????1198
    Conclusion?????1208
    Acknowledgments?????1209
            50            Palliative Care for the Child with Cancer 1210
    Christina K. Ullrich, Barbara M. Sourkes, and Joanne Wolfe
    Palliative Care: A Philosophy of Care?????1210
    Palliative Care for Children with Cancer?????1211
            51            Economic Issues in Pediatric Cancer 1228
    Susan K. Parsons, Pei-Jung Lin, and Joshua T. Cohen
    Patient-Physician Communication about Cost of Cancer Care?????1229
    Methods of Economic Evaluation?????1229
    Financing Care?????1234
    Family Impact?????1235
    Conclusion?????1236
        52        Pediatric Cancer Policy and Case Advocacy on Insurance, Education, and Employment 1238
    Susan L. Weiner and Gilbert P. Smith
    Part I: National Childhood Cancer Advocacy and Policy Priorities?????1238
    Part II: Case Advocacy For Individual Patients and Survivors?????1242
    Conclusion?????1246
        53        Complementary and Alternative Medical Therapies in Pediatric Oncology 1247
    Thomas W. McLean and Kathi J. Kemper
    Introduction?????1247
    Definitions?????1247
    Epidemiology?????1247
    Patients’ and Families’ Reasons for Using Complementary and Alternative Medicine?????1247
    Cam Therapies?????1249
    Ethical and Legal Considerations?????1253
    Summary?????1254
        54        Pediatric Oncology in Countries with Limited Resources 1256
    Raul C. Ribeiro, Guillermo L. Chantada, Ramandeep S. Arora, Federico Antillon, Mariana Kruger, and Ronald D. Barr
    Background?????1256
    Epidemiology of Pediatric Cancer Worldwide?????1256
    International Disparities and Barriers to Progress?????1258
    Pediatric Oncology Research in LMIC?????1260
    Index 1267
     
  • Editorial Reviews
    BMA Medical Book Awards 2016​: Oncology – Highly Commended
    ​The British Medical Association honored Principles and Practice of Pediatric Oncology, 7th Edition with this prestigious award.

    Doody's Core Title (2017 Edition) 
    • 2.93 (Nursing - Oncology) - Essential Purchase Title
    • 2.47 (Health Sciences - Hematology/Oncology)
  • Review
  • Questions and Answers
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