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Neonatal and Pediatric Pharmacology

Therapeutic Principles in Practice
Publication Date
October 4, 2010
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  • Description
    Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.

    The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta.
  • Specs
    Product Format
    HC-Printed Cover
    Publication Date
    October 4, 2010
  • Sumner J. Yaffe MD
    Formerly Consulting Professor, Stanford University of Medicine, Division of Neonatal and Developmental Medicine, Palo Alto, CA
    Jacob V. Aranda MD, PhD, FRCP(C)
    Professor, Director, Pediatric Pharmacology Research Unit Network, Departments of Pediatrics, Pharmacology, and Pharmaceutical Sciences, Wayne State University; Chief, Division of Clinical Pharmacology and Toxicology, Attending Neonatologist, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI
  • Features
    -- NEW : New chapter on nutrient supplements
    -- NEW : New chapter on biotransformation of medications by human placenta
    -- NEW : Updated information on drug interactions
    -- NEW : Updated information on federal legislation
    --Evidence-based discussion of drugs in pediatric population
    --State-of-the-art discussion of what is known about the basic science of drugs in pediatrics
    --Written and edited by the foremost authorities in pediatric clinical pharmacology
  • Table of contents

    1: Introduction and Historical Perspectives

    2: Clinical Pharmacokinetics in Infants and Children

    3: Drug Action and Therapy in the Infant and Child

    4: Drug Metabolism and Disposition in Infants and Children

    5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics

    6: Compliance with Pediatric Medication Regimens

    7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations

    8: Ethics of Drug Research in Pediatric Populations

    9: Therapeutic Drug Monitoring

    10: Drug Formulations


    11: Developmental Toxicology

    12: Biotransformation of Medications by Human Placenta

    13: Maternal Drug Intake and the Newborn

    14: Principles of Neonatal Pharmacology

    15: Perinatal Origins of Adult Defects in Drug Metabolism

    16: Renal Function and Excretion of Drugs in the Newborn

    17: The Excretion of Drugs and Chemicals in Human Milk

    18: Drugs for Hyperbilirubinemia

    19: Drugs and Lung Development

    20: Pharmacologic Treatment of Neonatal Apnea

    21: Drugs and Perinatal Brain Injury

    22: Antiretroviral Pharmacology in Pregnant Women and Newborns


    23: Therapeutic Applications in Pediatric Intensive Care

    24: Drug Therapy in the Pediatric Emergency Department

    25: Drug Therapy in the Adolescent

    26: Topical Medications

    27: Ophthalmologic Drugs in Infants and Children


    28: Sulfonamides

    29: Penicillins, Cephalosporins, and Other Beta-Lactams

    30: Aminoglycosides and Glycopeptides

    31: Fluoroquinolones

    32: Macrolides, Chloramphenicol, and Tetracyclines

    33: Anthelminthic Drugs in Children

    34: Antituberculosis Drugs

    35: Antifungal Agents

    36: Antiviral Drugs: Treatment of the Fetus and Newborn

    37: Anticonvulsants

    38: Psychopharmacology in Children and Adolescents

    39: Antihistamine Drugs

    40: Antiasthmatics

    41: Antipyretics

    42: Cardiovascular Drugs

    43: Diuretics

    44: Clinical Pharmacology of Antineoplastic Drugs

    45: Immunosuppressive and Immunomodulatory Drugs

    46: Analgesic Agents

    47: Local Anesthetics for Infants and Children

    48: Nonsteroidal Anti-inflammatory Drugs

    49: Antihypertensive Agents

    50: Gastrointestinal Drugs

    51: Glucocorticoids

    52: Insulin and Diabetes Mellitus

    53: Thyroid Hormones

    54: Growth Hormone

    55: Hematologic Agents

    56: Nutrient Supplements

    57: Childhood Vaccines


    58: Epidemiology of Adverse Drug Effects

    59: Mechanisms of Adverse Drug Reactions

    60: Medication Errors

    61: Pediatric Poisonings and Antidotes

    62: Use of Herbal Products in Children: Risks and Unproven Benefits

    63: Neonatal Abstinence Syndromes

    64: Drug Interactions in Newborns and Children


    65: Drug Formulary for the Newborn

    66: Pediatric Drug Formulary
  • Editorial Reviews
    "This is truly the gold standard of pediatric and neonatal pharmacology. It is much more extensive than the standard pediatric drug formulary handbooks and its size means it is designed to be a reference in the office and not carried in one's lab coat pocket. However, it is a must-have reference for every pediatric ward and specialty unit since drug therapy is so essential and often misunderstood and misused."

    Weighted Numerical Score: 98 - 5 Stars!

    Doody Enterprises, Inc. book review, February 2011
    "Neonatal and Pediatric Pharmacology is a well-presented, comprehensive resource covering basic pediatric pharmacology and the therapeutic principles that underlie the use of medications in newborns and children. It will be a helpful reference for all practitioners who care for children and invaluable for those who conduct research or teach."

    John L. Zeller, MD, PhD, Contributing Editor, Journal of the American Medical Association
  • Review
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