Home / Medicine / Epilepsy
9780781757775
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9780781757775
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September 28, 2007
2007-09-28
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9780781757775
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Metabolic Disorders, University Hospital Robert Debr\u0026#233;, Paris, France\u003c/DIV\u003e\u003c/dd\u003e\u003c/dl\u003e\u003cdl\u003e\u003cdt\u003eMarc A Dichter MD, PhD\u003c/dt\u003e\u003cdd\u003e\u003cDIV\u003eProfessor of Neurology and Pharmacology and David Mahoney Institute of Neurological Sciences, Departments of Neurology and Pharmacology and the University of Pennsylvania School of Medicine, Philadelphia, PA\u003c/DIV\u003e\u003c/dd\u003e\u003c/dl\u003e\u003cdl\u003e\u003cdt\u003eSolomon  Mosh\u0026#233; MD\u003c/dt\u003e\u003c/dl\u003e\u003cdl\u003e\u003cdt\u003eEmilio  Perucca MD\u003c/dt\u003e\u003c/dl\u003e\u003cdl\u003e\u003cdt\u003eMichael  Trimble 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EPILEPSY\u003c/B\u003e\u003c/P\u003e  \u003cP\u003eOverview: Epidemiology, Pathology, and Genetics\u003c/p\u003e  \u003cP\u003eEpilepsy: Historical Perspectives  Neuropathology\u003c/p\u003e  \u003cP\u003e\u003cB\u003eEPIDEMIOLOGY\u003c/B\u003e\u003c/p\u003e  \u003cp\u003eIncidence and Prevalence\u003c/p\u003e  \u003cp\u003eThe Natural History and Prognosis of  Epilepsy\u003c/P\u003e  \u003cP\u003e\u003cB\u003eNEUROPATHOLOGY\u003c/B\u003e\u003c/p\u003e  \u003cp\u003eGeneral Neuropathology of Epilepsy\u003c/p\u003e  \u003cp\u003eHippocampal Sclerosis\u003c/p\u003e  \u003cp\u003e\u003cb\u003eGENETICS\u003c/b\u003e\u003c/P\u003e  \u003cp\u003eGenetic Epidemiology\u003c/p\u003e  \u003cp\u003eEEG Traits\u003c/p\u003e  \u003cP\u003e\u003cB\u003eSECTION II THE NEUROBIOLOGY  OF EPILEPSY\u003c/B\u003e\u003c/p\u003e  \u003cp\u003eOverview: The Neurobiology of Epilepsy\u003c/p\u003e  \u003cp\u003e\u003cb\u003eMECHANISMS OF NORMAL  NEURONAL EXCITABILITY\u003c/b\u003e\u003c/p\u003e  \u003cp\u003eControl of Neuronal Excitability\u003c/p\u003e  \u003cp\u003eExcitatory Synaptic Transmission\u003c/p\u003e  \u003cp\u003eNeocortical Anatomy and Physiology\u003c/p\u003e  \u003cp\u003eThalamocortical Anatomy and Physiology\u003c/P\u003e  \u003cP\u003e\u003cB\u003eMECHANISMS OF EPILEPTOGENESIS  AND EPILEPTOGENICITY\u003c/B\u003e\u003c/p\u003e  \u003cp\u003eGenetic Models of Epilepsy\u003c/p\u003e  \u003cp\u003eSeizure Mechanisms and Vulnerability in the Developing Brain\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSECTION III PHENOMENOLOGY\u003c/b\u003e\u003c/P\u003e  \u003cp\u003eOverview: Phenomenology\u003c/p\u003e  \u003cp\u003e\u003cb\u003eEPILEPTIC SEIZURES\u003c/b\u003e\u003c/P\u003e  \u003cp\u003eSimple Motor Seizures\u003c/P\u003e  \u003cp\u003eLimbic Seizures\u003c/p\u003e  \u003cp\u003eEpileptic Spasms\u003c/p\u003e  \u003cP\u003e\u003cB\u003eSTATUS EPILEPTICUS\u003c/B\u003e\u003c/p\u003e  \u003cp\u003eGeneralized Convulsive Status Epilepticus\u003c/p\u003e  \u003cp\u003eAbsence Status Epilepticus\u003c/P\u003e  \u003cp\u003eMyoclonic Status Epilepticus\u003c/p\u003e  \u003cP\u003e\u003cB\u003eEPILEPTIC DISORDERS\u003c/B\u003e\u003c/p\u003e  \u003cp\u003eClassification of the Epilepsies\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSECTION IV DIAGNOSTIC  EVALUATION\u003c/p\u003e  \u003cp\u003eOverview: Diagnostic Evaluation\u003c/p\u003e  \u003cp\u003e\u003cb\u003eROUTINE INVESTIGATIONS\u003c/b\u003e\u003c/p\u003e  \u003cp\u003eHistory and Physical Examination\u003c/P\u003e  \u003cP\u003e\u003cB\u003eEEG\u003c/B\u003e\u003c/p\u003e  \u003cp\u003ePhysiologic Basis of the Electroencephalogram and Local Field Potentials\u003c/p\u003e  \u003cp\u003eIctal Electroencephalogram\u003c/p\u003e  \u003cp\u003ePolygraphic Recordings\u003c/P\u003e  \u003cP\u003e\u003cB\u003eNEUROIMAGING\u003c/B\u003e\u003c/p\u003e  \u003cp\u003ePositron Emission Tomography\u003c/p\u003e  \u003cp\u003eMagnetic Resonance Spectroscopy\u003c/p\u003e  \u003cp\u003eComputational Anatomy\u003c/P\u003e  \u003cP\u003e\u003cB\u003eNEW DIRECTIONS\u003c/B\u003e\u003c/p\u003e  \u003cp\u003eSeizure Prediction\u003c/p\u003e  \u003cp\u003eMicrodialysis\u003c/p\u003e  \u003cp\u003eTranscranial Magnetic Stimulation\u003c/p\u003e  \u003cp\u003eCellular Imaging of Epilepsy\u003c/p\u003e  \u003cP\u003e\u003cB\u003eNEUROPSYCHOLOGICAL EVALUATION\u003c/B\u003e\u003c/p\u003e  \u003cP\u003e\u003cB\u003eLONG-TERM MONITORING\u003c/B\u003e\u003c/p\u003e  \u003cp\u003e\u003ci\u003eVOLUME II\u003c/i\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSECTION V  GENERAL  TREATMENT CONSIDERATIONS\u003c/b\u003e\u003c/P\u003e  \u003cp\u003eOverview: General Approaches to  Treatment\u003c/p\u003e  \u003cp\u003e\u003cb\u003eGENERAL CONSIDERATIONS\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003ePRINCIPLES OF DRUG TREATMENT\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSTRATEGIES FOR  PHARMACOTHERAPY\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSPECIAL THERAPEUTIC  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\u003cp\u003e\u003cb\u003eBIORHYTHMS AND THE AUTONOMIC  NERVOUS SYSTEM\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eCOMORBIDITY\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eNEUROENDOCRINOLOGY\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003ci\u003eVOLUME III\u003c/i\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSECTION IX PSYCHIATRIC AND  SOCIAL ISSUES\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003ePSYCHIATRIC ISSUES\u003c/b\u003e\u003c/P\u003e  \u003cp\u003e\u003cb\u003eSOCIAL ISSUES\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSECTION X EPILEPSY  SYNDROMES\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eNEONATAL SYNDROMES\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSYNDROMES OF INFANCY AND EARLY  CHILDHOOD\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eSYNDROMES OF LATER CHILDHOOD  AND ADOLESCENCE\u003c/b\u003e\u003c/p\u003e  \u003cp\u003e\u003cb\u003eNON AGE-RELATED AND SPECIAL  SYNDROMES\u003c/b\u003e\u003c/p\u003e  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  • Description

    Written and edited by world-renowned authorities, this three-volume work is, to quote a reviewer, 'the definitive textbook about seizures and epilepsy'. This Second Edition is thoroughly updated and gives you a complete print and multimedia package: the three-volume set plus access to an integrated content Website.

    More than 300 chapters cover the spectrum of biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Included are detailed discussions of seizure types and epilepsy syndromes; relationships between physiology and clinical events; psychiatric and medical comorbidity; conditions that could be mistaken for epilepsy; and an increasing range of pharmacologic, surgical, and alternative therapies, including vagus nerve stimulation and deep brain stimulation. This edition describes many new antiepileptic drugs, major advances in surgical treatment, and state-of-the-art neuroimaging, EEG, and other technologies for diagnosis and seizure prediction.

    A companion Website offers instant access to the complete, fully searchable text, plus an image bank of additional figures, video footage, and annual updates to selected chapters.

  • Specs
    Edition
    2
    ISBN/ISSN
    9780781757775
    Product Format
    HC-Printed Cover
    Pages
    3056
    Illustration
    1000
    Table
    416
    Publication Date
    September 28, 2007
    Weight
    15.75
  • About The Author(s)
    Jerome Engel Jr
    Timothy A Pedley MD
    Henry and Lucy Moses Professor of Neurology, Chairman, Department of Neurology, Neurologist-in-Chief, Department of Neurology, Columbia University Medical Center, New York, NY; Neurologist-in-Chief, Neurological Institute of New York, Columbia-Presbyterian Medical Center, New York, NY
    Jean Aicardi MD, FRCP
    Professor and INSERM Research Director, Department of Child Neurology and Metabolic Disorders, University Hospital Robert Debré, Paris, France
    Marc A Dichter MD, PhD
    Professor of Neurology and Pharmacology and David Mahoney Institute of Neurological Sciences, Departments of Neurology and Pharmacology and the University of Pennsylvania School of Medicine, Philadelphia, PA
    Solomon Moshé MD
    Emilio Perucca MD
    Michael Trimble MD
  • Features
    --Print and multimedia package: text of Second Edition plus integrated content Website
    --Comprehensive coverage from molecular biology to public health concerns in developing countries
    --Thorough discussions of epileptic seizure types and epilepsy syndromes
    --Detailed descriptions of pharmacotherapy, surgical therapy, and alternative treatments
    --Discussions of psychiatric and medical comorbidity
    --Detailed discussions of conditions that could be mistaken for epilepsy
    --

    SECOND EDITION HIGHLIGHTS:

    • A complete print and multimedia package: the three-volume print textbook plus access to an integrated content Website
    • Major advances in understanding basic mechanisms of epilepsy and its consequences have been incorporated
    • Coverage of the latest developments in surgical approaches to treatment, including vagal nerve stimulation
    • Enhanced coverage of neuroimaging and EEG, for diagnosis and seizure prediction
    • Extensive discussion of the many new antiepileptic drugs for managing seizure intensity and frequency, and their side effects
    • New or completely revised chapters: receptor subunits and intracellular mechanisms (in neuronal excitability); updates on seizure types and syndromes as outlined by the International League Against Epilepsy; new information on gelastic seizures; seizure prediction; SPECT imaging; other applications of MRI
  • Table of contents

    VOLUME I

    Introduction: What Is Epilepsy?

    SECTION 1 EPIDEMIOLOGY, PATHOLOGY, AND GENETICS OF EPILEPSY

    Overview: Epidemiology, Pathology, and Genetics

    Epilepsy: Historical Perspectives Neuropathology

    EPIDEMIOLOGY

    Incidence and Prevalence

    The Natural History and Prognosis of Epilepsy

    NEUROPATHOLOGY

    General Neuropathology of Epilepsy

    Hippocampal Sclerosis

    GENETICS

    Genetic Epidemiology

    EEG Traits

    SECTION II THE NEUROBIOLOGY OF EPILEPSY

    Overview: The Neurobiology of Epilepsy

    MECHANISMS OF NORMAL NEURONAL EXCITABILITY

    Control of Neuronal Excitability

    Excitatory Synaptic Transmission

    Neocortical Anatomy and Physiology

    Thalamocortical Anatomy and Physiology

    MECHANISMS OF EPILEPTOGENESIS AND EPILEPTOGENICITY

    Genetic Models of Epilepsy

    Seizure Mechanisms and Vulnerability in the Developing Brain

    SECTION III PHENOMENOLOGY

    Overview: Phenomenology

    EPILEPTIC SEIZURES

    Simple Motor Seizures

    Limbic Seizures

    Epileptic Spasms

    STATUS EPILEPTICUS

    Generalized Convulsive Status Epilepticus

    Absence Status Epilepticus

    Myoclonic Status Epilepticus

    EPILEPTIC DISORDERS

    Classification of the Epilepsies

    SECTION IV DIAGNOSTIC EVALUATION

    Overview: Diagnostic Evaluation

    ROUTINE INVESTIGATIONS

    History and Physical Examination

    EEG

    Physiologic Basis of the Electroencephalogram and Local Field Potentials

    Ictal Electroencephalogram

    Polygraphic Recordings

    NEUROIMAGING

    Positron Emission Tomography

    Magnetic Resonance Spectroscopy

    Computational Anatomy

    NEW DIRECTIONS

    Seizure Prediction

    Microdialysis

    Transcranial Magnetic Stimulation

    Cellular Imaging of Epilepsy

    NEUROPSYCHOLOGICAL EVALUATION

    LONG-TERM MONITORING

    VOLUME II

    SECTION V GENERAL TREATMENT CONSIDERATIONS

    Overview: General Approaches to Treatment

    GENERAL CONSIDERATIONS

    PRINCIPLES OF DRUG TREATMENT

    STRATEGIES FOR PHARMACOTHERAPY

    SPECIAL THERAPEUTIC CONSIDERATIONS

    ALTERNATIVE APPROACHES

    SECTION VI ANTIEPILEPTIC DRUGS

    ANTIEPILEPTIC DRUG DEVELOPMENT

    ANTIEPILEPTIC DRUGS

    SECTION VII SURGICAL THERAPY

    CANDIDATE SELECTION

    INVASIVE MONITORING TECHNIQUES

    FUNCTIONAL MAPPING TECHNIQUES

    THERAPEUTIC SURGICAL PROCEDURES

    POSTOPERATIVE FOLLOW-UP

    SECTION VIII CLINICAL BIOLOGY OF EPILEPSY>/b>

    BIORHYTHMS AND THE AUTONOMIC NERVOUS SYSTEM

    COMORBIDITY

    NEUROENDOCRINOLOGY

    VOLUME III

    SECTION IX PSYCHIATRIC AND SOCIAL ISSUES

    PSYCHIATRIC ISSUES

    SOCIAL ISSUES

    SECTION X EPILEPSY SYNDROMES

    NEONATAL SYNDROMES

    SYNDROMES OF INFANCY AND EARLY CHILDHOOD

    SYNDROMES OF LATER CHILDHOOD AND ADOLESCENCE

    NON AGE-RELATED AND SPECIAL SYNDROMES

    DISEASES ASSOCIATED WITH EPILEPSY

    SECTION XI DISORDERS THAT CAN BE CONFUSED WITH EPILEPSY

    SYSTEMIC DISTURBANCES

    NEUROLOGICAL DISTURBANCES

    PSYCHIATRIC DISTURBANCES

    SECTION XII DELIVERY OF HEALTH CARE AND SOCIOECONOMIC ISSUES

    ORGANIZATION OF HEALTH CARE IN DIFFERENT COUNTRIES

    SPECIALIZED CENTERS FOR EPILEPSY

    COST AND ALLOCATION OF RESOURCES

    Subject Index

  • Review