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Clinical Pharmacokinetics and Pharmacodynamics

Concepts and Applications
9780781750097
ISBN/ISSN
9780781750097
Publication Date
January 28, 2010
2010-01-28
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IN STOCK
9780781750097
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  • Description
    Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

    A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.
  • Specs
    Edition
    4
    ISBN/ISSN
    9780781750097
    Product Format
    HC-Printed Cover
    Pages
    864
    Illustration
    470
    Table
    180
    Edition
    4
    Publication Date
    January 28, 2010
    Weight
    3.95
  • Malcolm Rowland
    Thomas N. Tozer PharmD, PhD
    Professor Emeritus, School of Pharmacy, University of California, San Francisco, CA; Adjunct Professor of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA
  • Features
    -- New! 'Key Relationships' section at end of each chapter highlights the core mathematical concepts presented and aids students in solving the review problems.
    -- New! Expanded coverage of topical areas, including (1) integration of pharmacokinetics with pharmacodynamics; (2) molecular and mechanistic processes as they relate to pharmacokinetics of drugs; (3) individual variations in drug response; (4) role of enzymes, transporters, and genetics; (5) new sections on Turnover Concepts and Dialysis.
    -- New! Interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.
    -- New! Chapter 21: Protein Drugs, reflecting the rapid increase in recent years in the number of such medicines that have become a part of the armamentarium of modern therapeutics.
    -- New! Chapter 22: Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data, concepts that improve the chances of selecting compounds that have desirable pharmacokinetic characteristics and help ensure their subsequent optimal use.
    --Learning Objectives and Study Problems, with answers and detailed explanations at the end of the book.
    --Hundreds of pharmacokinetic/pharmacodynamic graphs for application and intensive study of pk/pd effects and concepts.
    --Updated and new examples and review problems for each chapter.
  • Table of contents
    Preface

    Definition of Symbols

    Non-Proprietary and Brand Names of Drugs in Text and Illustrations

    I. Basic Considerations
    1. Therapeutic Relevance
    2. Fundamental Concepts and Terminology

    II. Exposure and Response after a Single Dose
    3. Kinetics Following an Intravenous Bolus Dose
    4. Membranes and Distribution
    5. Elimination
    6. Kinetics Following an Extravascular Dose
    7. Absorption
    8. Response Following a Single Dose

    III. Therapeutic Regimens
    9. Therapeutic Window
    10. Constant-Rate Input
    11. Multiple Dose Regimens

    IV. Individualization
    12.Variability
    13.Genetics
    14. Age, Weight, and Gender
    15. Disease
    16. Nonlinearities
    17. Drug Interactions
    18. Initiating and Managing Therapy

    V. Supplemental Topics
    19. Distribution Kinetics
    20. Metabolites and Drug Response
    21. New! Protein Drugs
    22. New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data

    Appendices
    A. Assessment of AUC
    B. Ionization and the pH Partition Hypothesis
    C. Distribution of Drugs Extensively Bound to Plasma Proteins
    D. Plasma-to-Blood Concentration Ratio
    E. Well-stirred Model of Hepatic Clearance
    F. Absorption Kinetics
    G. Wagner-Nelson Method
    H. Mean Residence Time
    I. Amount of Drug in Body on Accumulation to Plateau
    J. Answers to Study Problems
  • Review
  • Questions and Answers

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